1N26: IL-6 Receptor alpha chain

Crystal Structure of the extra-cellular domains of Human Interleukin-6 Receptor alpha chain. Determined by X-ray diffraction at 2.4 Å resolution. Released 18 Dec 2002.

Method: X-ray diffraction
Resolution: 2.4 Å
Organism: Homo sapiens
Chains: 1
Atoms: 2,580
Mol. weight: 38.54 kDa
Ligands: CYS, NAG
Released: 18 Dec 2002

Explore 1N26 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1N26 contains 8 α-helices and 26 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 26 β-strands

Element	Residues	Length	Sheet
β-strand	15-18	4	1
β-strand	24-27	4	2
β-strand	38-44	7	1
β-strand	53-58	6	1
β-strand	61-64	4	2
α-helix	69-71	3
β-strand	73-78	6	1
β-strand	86-91	6	1
α-helix	93-98	6
β-strand	101-103	3	3
β-strand	104	1	4
α-helix	110	1
β-strand	111-115	5	3
β-strand	126-134	9	5
β-strand	140-145	6	5
β-strand	146-149	4	3
β-strand	154-159	6	3
β-strand	168-177	10	5
β-strand	180-183	4	5
α-helix	184-186	3
β-strand	187-190	4	5
β-strand	195	1	4
α-helix	197-200	4
β-strand	201-207	7	6
β-strand	215-220	6	6
β-strand	232-240	9	7
β-strand	247-250	4	7
α-helix	251	1
α-helix	252-254	3
β-strand	257-260	4	6
β-strand	269-277	9	7
β-strand	281	1	7
α-helix	284-290	7
β-strand	291-293	3	7

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
IL-6 Receptor alpha chain	A	protein	325	Homo sapiens	P08887 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1N26_1 IL-6 Receptor alpha chain (chains A)
LAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHWVLRKPAAGSHPSRWAGMGR
RLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPRST
PSLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVASSVG
SKFSKTQTFQGCGILQPDPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRA
ERSKTFTTWMVKDLQHHCVIHDAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESR
SPPAENEVSTPMQALTTNKDDDNIL

Ligands and cofactors

ID	Name	Formula	Copies
CYS	Cysteine	C3 H7 N O2 S	1
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose	C8 H15 N O6	2

Water and common crystallization additives (SO4) are not listed.

Primary citation

Structure of the extracellular domains of the human interleukin-6 receptor alpha-chain. Varghese, J.N., Moritz, R.L., Lou, M.-Z. et al. Proc Natl Acad Sci U S A (2002) 99:15959-15964. DOI 10.1073/pnas.232432399 · PubMed

Other PDB entries of the same protein (UniProt P08887 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5FUC 2.7 Å, Biophysical and cellular characterisation of a junctional epitope antibody that locks…
7DC8 2.76 Å, Crystal structure of Switch Ab Fab and hIL6R in complex with ATP
8QY5 3.1 Å, Structure of interleukin 6.
8QY6 3.16 Å, Structure of interleukin 6 (gp130 P496L mutant).
8IOW 3.2 Å, Cryo-EM structure of the sarilumab Fab/IL-6R complex
8D82 3.22 Å, Cryo-EM structure of human IL-6 signaling complex in detergent: model containing full…
8J6F 3.3 Å, Cryo-EM structure of the Tocilizumab Fab/IL-6R complex
1P9M 3.65 Å, Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex
2ARW The solution structure of the membrane proximal cytokine receptor domain of the human…

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