Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes. Determined by X-ray diffraction at 3.1 Å resolution. Released 31 May 1994.
Explore 1NRO in 3D Show helices and sheets RCSB PDB PDBe
1NRO contains 9 α-helices and 30 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 17 | 1 | 1 |
| β-strand | 20-21 | 2 | 2 |
| β-strand | 30-35 | 6 | 3 |
| β-strand | 36 | 1 | 4 |
| β-strand | 38 | 1 | 4 |
| β-strand | 42-46 | 5 | 3 |
| β-strand | 52-54 | 3 | 3 |
| α-helix | 56-59 | 4 | |
| α-helix | 60B-60D | 3 | |
| β-strand | 64-68 | 5 | 3 |
| β-strand | 72 | 1 | 5 |
| β-strand | 81-83 | 3 | 3 |
| β-strand | 85 | 1 | 6 |
| β-strand | 89-90 | 2 | 3 |
| β-strand | 95 | 1 | 7 |
| β-strand | 100 | 1 | 7 |
| β-strand | 104-105 | 2 | 3 |
| β-strand | 108 | 1 | 6 |
| α-helix | 111-114 | 4 | |
| β-strand | 115 | 1 | 8 |
| β-strand | 118 | 1 | 8 |
| β-strand | 122 | 1 | 9 |
| α-helix | 128-129B | 4 | |
| β-strand | 136 | 1 | 10 |
| β-strand | 137-138 | 2 | 9 |
| β-strand | 154 | 1 | 5 |
| β-strand | 156-157 | 2 | 2 |
| β-strand | 160 | 1 | 10 |
| α-helix | 165-168 | 4 | |
| β-strand | 180-181 | 2 | 11 |
| β-strand | 189 | 1 | 1 |
| β-strand | 198-202 | 5 | 9 |
| β-strand | 207-212 | 6 | 9 |
| β-strand | 213-215 | 3 | 11 |
| β-strand | 227-229 | 3 | 11 |
| α-helix | 235-240 | 6 | |
| α-helix | 242-245 | 4 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 8-10 | 3 | |
| α-helix | 14C-14J | 8 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Alpha-thrombin (small subunit) | L | protein | 36 | Homo sapiens | P00734 (AlphaFold model) |
| Alpha-thrombin (large subunit) | H | protein | 259 | Homo sapiens | P00734 (AlphaFold model) |
| Receptor based peptide nrp | R | protein | 27 | Homo sapiens | P25116 (AlphaFold model) |
>1NRO_1 ALPHA-THROMBIN (SMALL SUBUNIT) (chains L) TFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGR
>1NRO_2 ALPHA-THROMBIN (LARGE SUBUNIT) (chains H) IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLL VRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCL PDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIR ITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFY THVFRLKKWIQKVIDQFGE
>1NRO_3 RECEPTOR BASED PEPTIDE NRP (chains R) LDPRPFLLRNPNDKYEPFWEDEEKNES
Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes. Mathews, I.I., Padmanabhan, K.P., Ganesh, V. et al. Biochemistry (1994) 33:3266-3279. DOI 10.1021/bi00177a018 · PubMed
Other PDB entries of the same protein (UniProt P00734 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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