Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors. Determined by X-ray diffraction at 1.58 Å resolution. Released 13 May 2003.
Explore 1O2G in 3D Show helices and sheets RCSB PDB PDBe
1O2G contains 15 α-helices and 25 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 17 | 1 | 2 |
| β-strand | 20-21 | 2 | 3 |
| α-helix | 22-23 | 2 | |
| β-strand | 30-35 | 6 | 4 |
| β-strand | 39-46 | 8 | 4 |
| β-strand | 51-54 | 4 | 4 |
| α-helix | 56-58 | 3 | |
| β-strand | 60-60A | 2 | 5 |
| α-helix | 60B-60D | 3 | |
| β-strand | 60F-60G | 2 | 5 |
| α-helix | 61-63 | 3 | |
| β-strand | 64-68 | 5 | 4 |
| β-strand | 72 | 1 | 6 |
| β-strand | 81-83 | 3 | 4 |
| β-strand | 85-90 | 6 | 4 |
| β-strand | 95 | 1 | 7 |
| β-strand | 100 | 1 | 7 |
| β-strand | 104-108 | 5 | 4 |
| α-helix | 120-121 | 2 | |
| β-strand | 122 | 1 | 3 |
| β-strand | 123 | 1 | 1 |
| α-helix | 124 | 1 | |
| α-helix | 126-129C | 7 | |
| β-strand | 135-140 | 6 | 3 |
| β-strand | 154 | 1 | 6 |
| β-strand | 156-162 | 7 | 3 |
| α-helix | 165-169 | 5 | |
| α-helix | 175-176 | 2 | |
| β-strand | 180-183 | 4 | 3 |
| α-helix | 186-186B | 3 | |
| β-strand | 189 | 1 | 2 |
| β-strand | 198-202 | 5 | 3 |
| β-strand | 207-215 | 9 | 3 |
| β-strand | 226-230 | 5 | 3 |
| α-helix | 231-245 | 15 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 56-58 | 3 | |
| α-helix | 61-63 | 3 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 1F-1E | 2 | 1 |
| α-helix | 8-10 | 3 | |
| α-helix | 14C-14I | 7 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Thrombin | L | protein | 36 | Homo sapiens | P00734 (AlphaFold model) |
| Thrombin | H | protein | 259 | Homo sapiens | P00734 (AlphaFold model) |
| Acetyl hirudin | I | protein | 11 | Hirudo medicinalis | P28504 (AlphaFold model) |
>1O2G_1 THROMBIN (chains L) TFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGR
>1O2G_2 THROMBIN (chains H) IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLL VRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCL PDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIR ITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFY THVFRLKKWIQKVIDQFGE
>1O2G_3 ACETYL HIRUDIN (chains I) DFEEIPEEYLQ
| ID | Name | Formula | Copies |
|---|---|---|---|
| 696 | 3-{5-[amino(iminio)methyl]-1H-indol-2-yl}-1,1'-biphenyl-2-olate | C21 H17 N3 O | 1 |
Water and common crystallization additives (NA) are not listed.
Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors. Katz, B.A., Elrod, K., Verner, E. et al. J Mol Biol (2003) 329:93-120. DOI 10.1016/S0022-2836(03)00399-1 · PubMed
Other PDB entries of the same protein (UniProt P00734 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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