1OGA: HLA class I histocompatibility antigen

A structural basis for immunodominant human T-cell receptor recognition. Determined by X-ray diffraction at 1.4 Å resolution. Released 19 Jun 2003.

Method: X-ray diffraction
Resolution: 1.4 Å
Organism: HOMO SAPIENS
Chains: 5
Atoms: 7,192
Mol. weight: 96.96 kDa
Released: 19 Jun 2003

Explore 1OGA in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1OGA contains 24 α-helices and 74 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 11 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	3-12	10	1
α-helix	20	1
β-strand	21-28	8	1
β-strand	31-37	7	1
β-strand	46-47	2	1
α-helix	50-52	3
α-helix	57-84	28
β-strand	94-103	10	1
β-strand	109-118	10	1
β-strand	121-126	6	1
β-strand	133-135	3	1
α-helix	138-149	12
α-helix	152-158	7
α-helix	159-163	5
α-helix	164-174	11
α-helix	176-179	4
β-strand	183	1	2
α-helix	184-185	2
β-strand	186-193	8	3
β-strand	198-208	11	3
β-strand	209	1	2
β-strand	214-219	6	4
β-strand	223	1	4
β-strand	228-230	3	3
α-helix	231-233	3
β-strand	234-235	2	3
β-strand	241-250	10	3
α-helix	254-256	3
β-strand	257-262	6	4
β-strand	270-273	4	4

Chain B: 3 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	5
α-helix	4-5	2
β-strand	6-11	6	6
β-strand	21-30	10	6
β-strand	31	1	5
β-strand	36-41	6	7
β-strand	44-45	2	7
α-helix	46	1
β-strand	50-51	2	6
α-helix	52-54	3
β-strand	55-56	2	6
β-strand	62-70	9	6
β-strand	78-83	6	7
β-strand	91-94	4	7

Chain D: 4 helices, 18 β-strands

Element	Residues	Length	Sheet
β-strand	6-8	3	8
β-strand	11-15	5	9
β-strand	20-25	6	8
β-strand	33-38	6	9
β-strand	45-50	6	9
β-strand	56-59	4	8
β-strand	62-66	5	8
β-strand	72-77	6	8
α-helix	82-84	3
β-strand	86-93	8	9
β-strand	99-101	3	9
α-helix	102	1
β-strand	105-110	6	9
β-strand	119-124	6	10
β-strand	125	1	11
β-strand	132-137	6	10
β-strand	153-155	3	10
α-helix	156-158	3
β-strand	159-163	5	10
α-helix	164-166	3
β-strand	168-177	10	10
β-strand	198	1	10

Chain E: 6 helices, 26 β-strands

Element	Residues	Length	Sheet
β-strand	6-7	2	12
β-strand	12-16	5	13
β-strand	21-23	3	14
β-strand	26-27	2	12
β-strand	33-39	7	13
β-strand	45-51	7	13
β-strand	58-59	2	13
β-strand	66-68	3	14
β-strand	75	1	12
β-strand	78-80	3	14
β-strand	89-96	8	13
β-strand	104-105	2	13
β-strand	109-114	6	13
α-helix	117-119	3
β-strand	121	1	15
α-helix	122-123	2
β-strand	124-128	5	11
α-helix	129-131	3
α-helix	132-138	7
β-strand	140-150	11	11
β-strand	151	1	15
β-strand	155-161	7	16
β-strand	164-166	3	16
β-strand	170-172	3	11
β-strand	177-178	2	11
β-strand	188-197	10	11
α-helix	198-201	4
β-strand	207-214	8	16
β-strand	217	1	17
α-helix	228-229	2
β-strand	231	1	17
β-strand	233-240	8	16

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
HLA class I histocompatibility antigen	A	protein	276	HOMO SAPIENS	P04439 (AlphaFold model)
Beta-2-microglobulin	B	protein	100	HOMO SAPIENS	P61769 (AlphaFold model)
Gilgfvftl	C	protein	9	HOMO SAPIENS
T-cell receptor alpha chain V region	D	protein	215	HOMO SAPIENS	P01848 (AlphaFold model)
T-cell receptor beta chain C region	E	protein	252	HOMO SAPIENS	P01850 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1OGA_1 HLA CLASS I HISTOCOMPATIBILITY ANTIGEN (chains A)
GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYW
DGETRKVKAHSQTHRVDLGTLRGYYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDG
KDYIALKEDLRSWTAADMAAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQ
RTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGT
FQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEP

Sequence of entity 2 (B), FASTA

>1OGA_2 BETA-2-MICROGLOBULIN (chains B)
MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKD
WSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

Sequence of entity 3 (C), FASTA

>1OGA_3 GILGFVFTL (chains C)
GILGFVFTL

Sequence of entity 4 (D), FASTA

>1OGA_4 T-CELL RECEPTOR ALPHA CHAIN V REGION (chains D)
MQLLEQSPQFLSIQEGENLTVYCNSSSVFSSLQWYRQEPGEGPVLLVTVVTGGEVKKLKR
LTFQFGDARKDSSLHITAAQPGDTGLYLCAGAGSQGNLIFGKGTKLSVKPNIQNPDPAVY
QLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSD
FACANAFNNSIIPEDTFFPSPENDGGGCKHHHHHH

Sequence of entity 5 (E), FASTA

>1OGA_5 T-CELL RECEPTOR BETA CHAIN C REGION (chains E)
MVDGGITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSQIVNDFQKG
DIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSSRSSYEQYFGPGTRLTVTEDLKNV
FPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQ
PALNDSRYSLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAW
GRADQDRGGGCD

Primary citation

A Structural Basis for Immunodominant Human T Cell Receptor Recognition. Stewart-Jones, G.B.E., Mcmichael, A.J., Bell, J.I. et al. Nat Immunol (2003) 4:657. DOI 10.1038/NI942 · PubMed

Other PDB entries of the same protein (UniProt P04439 (AlphaFold model), which also has an AlphaFold model), best resolution first:

3MRE 1.1 Å, Crystal Structure of MHC class I HLA-A2 molecule complexed with EBV bmlf1-280-288…
3D25 1.3 Å, Crystal structure of HA-1 minor histocompatibility antigen bound to human class I MHC…
3MRG 1.3 Å, Crystal Structure of MHC class I HLA-A2 molecule complexed with HCV NS3-1073-1081…
6JOZ 1.35 Å, Crystal structure of BRLF peptide from EBV in complex with HLA-A1101.
5C0G 1.37 Å, HLA-A02 carrying YLGGPDFPTI
5N1Y 1.39 Å, HLA-A02 carrying MVWGPDPLYV
1I4F 1.4 Å, Crystal structure of HLA-A*0201/MAGE-A4-peptide complex
3MRB 1.4 Å, Crystal Structure of MHC class I HLA-A2 molecule complexed with HCMV pp65-495-503…
3MRK 1.4 Å, Crystal Structure of MHC class I HLA-A2 molecule complexed with AFP137 nonapeptide
6J2A 1.4 Å, The structure of HLA-A*3003/NP44
1X7Q 1.45 Å, Crystal structure of HLA-A*1101 with sars nucleocapsid peptide
5C0F 1.46 Å, HLA-A02 carrying RQWGPDPAAV

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