1OHR: Aspartylprotease

Viracept (R) (nelfinavir mesylate, AG1343): a potent orally bioavailable inhibitor of HIV-1 protease. Determined by X-ray diffraction at 2.1 Å resolution. Released 9 Dec 1998.

Method: X-ray diffraction
Resolution: 2.1 Å
Organism: Human immunodeficiency virus 1
Chains: 2
Atoms: 1,555
Mol. weight: 22.18 kDa
Ligands: 1UN
Released: 9 Dec 1998

Explore 1OHR in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1OHR contains 2 α-helices and 18 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 9 β-strands

Element	Residues	Length	Sheet
β-strand	2-3	2	1
β-strand	10-15	6	2
β-strand	18-24	7	2
β-strand	32-33	2	2
β-strand	43-49	7	2
β-strand	52-66	15	2
β-strand	69-77	9	2
β-strand	84-85	2	2
α-helix	87-90	4
β-strand	96-98	3	1

Chain B: 1 helix, 9 β-strands

Element	Residues	Length	Sheet
β-strand	2-3	2	1
β-strand	10-15	6	3
β-strand	18-24	7	3
β-strand	32-34	3	3
β-strand	43-49	7	3
β-strand	52-66	15	3
β-strand	69-78	10	3
β-strand	83-85	3	3
α-helix	87-90	4
β-strand	96-98	3	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Aspartylprotease	A, B	protein	99	Human immunodeficiency virus 1	Q9Q288

Sequence of entity 1 (A, B), FASTA

>1OHR_1 ASPARTYLPROTEASE (chains A, B)
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF

Ligands and cofactors

ID	Name	Formula	Copies
1UN	2-[2-hydroxy-3-(3-hydroxy-2-methyl-benzoylamino)-4-phenyl…	C32 H45 N3 O4 S	1

Primary citation

Viracept (nelfinavir mesylate, AG1343): a potent, orally bioavailable inhibitor of HIV-1 protease. Kaldor, S.W., Kalish, V.J., Davies 2nd., J.F. et al. J Med Chem (1997) 40:3979-3985. DOI 10.1021/jm9704098 · PubMed

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1OHR is part of these collections:

Drugs bound to their targets

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