1PN6: Elongation factor G

Domain-wise fitting of the crystal structure of T.thermophilus EF-G into the low resolution map of the release complex.Puromycin.EFG.GDPNP of E.coli 70S ribosome. Determined by electron microscopy at 10.8 Å resolution. Released 15 Jul 2003.

Method

Electron microscopy

Resolution

10.8 Å

Organism

Thermus thermophilus

Chains

1

Atoms

655

Mol. weight

76.91 kDa

Released

15 Jul 2003

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Molecules and chains

>1PN6_1 Elongation factor G (chains A)
MAVKVEYDLKRLRNIGIAAHIDAGKTTTTERILYYTGRIHKIGEVHEGAATMDFMEQERE
RGITITAAVTTCFWKDHRINIIDTPGHVDFTIEVERSMRVLDGAIVVFDSSQGVEPQSET
VWRQAEKYKVPRIAFANKMDKTGADLWLVIRTMQERLGARPVVMQLPIGREDTFSGIIDV
LRMKAYTYGNDLGTDIREIPIPEEYLDQAREYHEKLVEVAADFDENIMLKYLEGEEPTEE
ELVAAIRKGTIDLKITPVFLGSALKNKGVQLLLDAVVDYLPSPLDIPPIKGTTPEGEVVE
IHPDPNGPLAALAFKIMADPYVGRLTFIRVYSGTLTSGSYVYNTTKGRKERVARLLRMHA
NHREEVEELKAGDLGAVVGLKETITGDTLVGEDAPRVILESIEVPEPVIDVAIEPKTKAD
QEKLSQALARLAEEDPTFRVSTHPETGQTIISGMGELHLEIIVDRLKREFKVDANVGKPQ
VAYRETITKPVDVEGKFIRQTGGRGQYGHVKIKVEPLPRGSGFEFVNAIVGGVIPKEYIP
AVQKGIEEAMQSGPLIGFPVVDIKVTLYDGSYAEVDSSEMAFKIAGSMAIKEAVQKGDPV
ILEPIMRVEVTTPEEYMGDVIGDLNARRGQILGMEPRGNAQVIRAFVPLAEMFGYATDLR
SKTQGRGSFVMFFDHYQEVPKQVQEKLIKGQ

Primary citation

Locking and Unlocking of Ribosomal Motions. Valle, M., Zavialov, A., Sengupta, J. et al. Cell (2003) 114:123-134. DOI 10.1016/S0092-8674(03)00476-8 · PubMed

Related structures

Other PDB entries of the same protein (UniProt P13551 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 2BM0 2.4 Å, Ribosomal elongation factor G (EF-G) Fusidic acid resistant mutant T84A
• 2BV3 2.5 Å, Crystal structure of a mutant elongation factor G trapped with a GTP analogue
• 2BM1 2.6 Å, Ribosomal elongation factor G (EF-G) Fusidic acid resistant mutant G16V
• 1FNM 2.8 Å, Structure of thermus thermophilus ef-G H573A
• 2J7K 2.9 Å, Crystal structure of the T84A mutant EF-G:GDPCP complex
• 4M1K 2.95 Å, Crystal structure of elongation factor G (EFG)
• 4MYU 3.0 Å, Crystal structure of elongation factor G mutant(EFG)
• 4MYT 3.5 Å, Crystal structure of elongation factor G (EFG)
• 1KTV 3.8 Å, Crystal Structure of Elongation Factor G Dimer Without Nucleotide
• 2BCW 11.2 Å, Coordinates of the N-terminal domain of ribosomal protein L11,C-terminal domain of…
• 1JQM 18.0 Å, Fitting of L11 protein and elongation factor G (EF-G) in the cryo-em map of e. coli 70S…
• 1JQS 18.0 Å, Fitting of L11 protein and elongation factor G (domain G' and V) in the cryo-em map of…

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