1QO3: MHC class I H-2DD heavy chain

Complex between NK cell receptor Ly49A and its MHC class I ligand H-2Dd. Determined by X-ray diffraction at 2.3 Å resolution. Released 2 Jan 2000.

Method: X-ray diffraction
Resolution: 2.3 Å
Organisms: MUS MUSCULUS, HUMAN IMMUNODEFICIENCY VIRUS
Chains: 5
Atoms: 5,542
Mol. weight: 77.16 kDa
Released: 2 Jan 2000

Explore 1QO3 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1QO3 contains 19 α-helices and 45 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 9 helices, 18 β-strands

Element	Residues	Length	Sheet
β-strand	3-12	10	1
α-helix	20	1
β-strand	21-28	8	1
β-strand	31-37	7	1
β-strand	46-47	2	1
α-helix	50-52	3
α-helix	57-84	28
β-strand	94-103	10	1
β-strand	109-118	10	1
β-strand	121-126	6	1
β-strand	133-135	3	1
α-helix	138-150	13
α-helix	152-158	7
α-helix	159-163	5
α-helix	164-174	11
α-helix	176-179	4
β-strand	183	1	2
β-strand	186-193	8	3
β-strand	199-208	10	3
β-strand	209	1	2
β-strand	214-219	6	4
β-strand	229-230	2	3
β-strand	234-235	2	3
β-strand	241-249	9	3
α-helix	254-256	3
β-strand	257-262	6	4
β-strand	270-272	3	4

Chain B: 2 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	5
α-helix	4-5	2
β-strand	6-11	6	6
β-strand	21-30	10	6
β-strand	31	1	5
β-strand	36-41	6	7
β-strand	44-45	2	7
β-strand	50-51	2	6
α-helix	52-54	3
β-strand	55-56	2	6
β-strand	62-70	9	6
β-strand	78-83	6	7
β-strand	91-94	4	7

Chain C: 4 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	141-146	6	8
β-strand	149-158	10	8
α-helix	160-169	10
β-strand	173-174	2	8
α-helix	180-189	10
β-strand	195-202	8	8
α-helix	203-205	3
β-strand	207-210	4	8
α-helix	227-229	3
β-strand	232-235	4	8
β-strand	240-243	4	8
β-strand	249-256	8	8

Chain D: 4 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	141-146	6	8
β-strand	149-158	10	8
α-helix	160-169	10
β-strand	173-174	2	8
α-helix	180-189	10
β-strand	195-202	8	8
β-strand	207-210	4	8
α-helix	222-224	3
α-helix	227-229	3
β-strand	232-235	4	8
β-strand	240-243	4	8
β-strand	249-256	8	8

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
MHC class I H-2DD heavy chain	A	protein	277	MUS MUSCULUS	P01900 (AlphaFold model)
Beta-2-microglobulin	B	protein	100	MUS MUSCULUS	P01887 (AlphaFold model)
LY49A	C, D	protein	137	MUS MUSCULUS	P20937 (AlphaFold model)
HIV envelope glycoprotein 120 peptide	P	protein	10	HUMAN IMMUNODEFICIENCY VIRUS	P04582

Sequence of entity 1 (A), FASTA

>1QO3_1 MHC CLASS I H-2DD HEAVY CHAIN (chains A)
MSHSLRYFVTAVSRPGFGEPRYMEVGYVDNTEFVRFDSDAENPRYEPRARWIEQEGPEYW
ERETRRAKGNEQSFRVDLRTALRYYNQSAGGSHTLQWMAGCDVESDGRLLRGYWQFAYDG
CDYIALNEDLKTWTAADMAAQITRRKWEQAGAAERDRAYLEGECVEWLRRYLKNGNATLL
RTDPPKAHVTHHRRPEGDVTLRCWALGFYPADITLTWQLNGEELTQEMELVETRPAGDGT
FQKWASVVVPLGKEQKYTCHVEHEGLPEPLTLRWGKE

Sequence of entity 2 (B), FASTA

>1QO3_2 BETA-2-MICROGLOBULIN (chains B)
MIQKTPQIQVYSRHPPENGKPNILNCYVTQFHPPHIEIQMLKNGKKIPKVEMSDMSFSKD
WSFYILAHTEFTPTETDTYACRVKHASMAEPKTVYWDRDM

Sequence of entity 3 (C, D), FASTA

>1QO3_3 LY49A (chains C, D)
STVLDSLQHTGRGDKVYWFCYGMKCYYFVMDRKTWSGCKQTCQSSSLSLLKIDDEDELKF
LQLVVPSDSCWVGLSYDNKKKDWAWIDNRPSKLALNTRKYNIRDGGCMLLSKTRLDNGNC
DQVFICICGKRLDKFPH

Sequence of entity 4 (P), FASTA

>1QO3_4 HIV ENVELOPE GLYCOPROTEIN 120 PEPTIDE (chains P)
RGPGRAFVTI

Primary citation

Crystal Structure of a Lectin-Like Natural Killer Cell Receptor Bound to its Mhc Class I Ligand. Tormo, J., Natarajan, K., Margulies, D.H. et al. Nature (1999) 402:623. DOI 10.1038/45170 · PubMed

Other PDB entries of the same protein (UniProt P01900 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5WEU 1.58 Å, Crystal Structure of H2-Dd with disulfide-linked 10mer peptide
3ECB 1.7 Å, Crystal structure of mouse H-2Dd in complex with peptide P18-I10 derived from human…
8FHU 1.8 Å, Structure of Pyruvate dehydrogenase phosphatase regulatory subunit epitope presented by…
5T7G 1.96 Å, Crystal Structure of Murine MHC-I H-2Dd in complex with Murine Beta2-Microglobulin and a…
3E6H 2.1 Å, MHC CLASS I H-2Dd heavy chain complexed with Beta-2 Microglobulin and a variant peptide,…
5IVX 2.1 Å, Crystal Structure of B4.2.3 T-Cell Receptor and H2-Dd P18-I10 Complex
8FHL 2.19 Å, Structure of pyruvate dehydrogenase phosphatase regulatory subunit neoepitope presented…
8D5F 2.31 Å, The complex of Gtf2b neoantigen TGAARFDEF Presented by H2-Dd
5KD7 2.35 Å, Crystal Structure of Murine MHC-I H-2Dd in complex with Murine Beta2-Microglobulin and a…
6NPR 2.37 Å, Crystal structure of H-2Dd with C84-C139 disulfide in complex with gp120 derived peptide…
1BII 2.4 Å, The crystal structure of H-2DD MHC class I in complex with the HIV-1 derived peptide…
3E6F 2.41 Å, MHC CLASS I H-2Dd Heavy chain complexed with Beta-2 Microglobulin and a variant peptide,…

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