1R1A: Human rhinovirus serotype 1A

Name: PDB 1R1A: Crystal structure of human rhinovirus serotype 1A (HRV1A)
Published: 1990-07-15
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: virus

Crystal structure of human rhinovirus serotype 1A (HRV1A). Determined by X-ray diffraction at 3.2 Å resolution. Released 15 Jul 1990.

Method: X-ray diffraction
Resolution: 3.2 Å
Organism: Human rhinovirus 1A
Chains: 4
Atoms: 6,246
Mol. weight: 92.83 kDa
Released: 15 Jul 1990

Explore 1R1A in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1R1A contains 26 α-helices and 52 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain 1: 11 helices, 17 β-strands

Element	Residues	Length	Sheet
α-helix	6-10	5
β-strand	16	1	1
α-helix	17-18	2
β-strand	20	1	2
β-strand	34	1	3
α-helix	37-39	3
α-helix	47-50	4
β-strand	56	1	2
β-strand	61	1	1
α-helix	67-71	5
β-strand	75-83	9	4
β-strand	97-100	4	5
α-helix	107-113	7
β-strand	116-133	18	4
β-strand	143-148	6	5
α-helix	153-155	3
α-helix	162-164	3
β-strand	169-173	5	5
α-helix	178-180	3
β-strand	181-184	4	4
β-strand	193-194	2	4
β-strand	200	1	6
β-strand	209	1	6
β-strand	219-223	5	5
β-strand	233-251	19	4
α-helix	253-255	3
α-helix	278-280	3
β-strand	281	1	7

Chain 2: 7 helices, 18 β-strands

Element	Residues	Length	Sheet
β-strand	14-17	4	8
β-strand	22-25	4	8
β-strand	32-33	2	9
α-helix	34-36	3
α-helix	41-43	3
β-strand	54	1	9
β-strand	64-65	2	9
β-strand	69-70	2	10
β-strand	77-81	5	11
α-helix	82-85	4
α-helix	92-95	4
β-strand	99-111	13	9
β-strand	121-128	8	11
β-strand	134	1	12
α-helix	140-143	4
β-strand	154-156	3	11
β-strand	167	1	12
α-helix	183-185	3
β-strand	188-192	5	11
β-strand	198-203	6	9
β-strand	212-213	2	9
β-strand	220-226	7	11
α-helix	229-230	2
β-strand	241-242	2	10
β-strand	243-256	14	9

Chain 3: 8 helices, 17 β-strands

Element	Residues	Length	Sheet
β-strand	23	1	4
α-helix	30-32	3
β-strand	40	1	4
α-helix	43-47	5
α-helix	50	1
β-strand	51-52	2	3
β-strand	58	1	7
α-helix	59-61	3
α-helix	66-68	3
β-strand	69-72	4	3
β-strand	81-86	6	13
α-helix	100-103	4
β-strand	106-110	5	14
β-strand	113-119	7	3
β-strand	126-134	9	13
β-strand	136	1	15
β-strand	138	1	15
α-helix	139-141	3
α-helix	144-148	5
β-strand	151-156	6	13
β-strand	162-167	6	3
β-strand	176-177	2	14
β-strand	188-198	11	13
β-strand	207-215	9	3
β-strand	220-224	5	14

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Human rhinovirus 1A coat protein (subunit VP1)	1	protein	287	Human rhinovirus 1A	P23008 (AlphaFold model)
Human rhinovirus 1A coat protein (subunit VP2)	2	protein	263	Human rhinovirus 1A	P23008 (AlphaFold model)
Human rhinovirus 1A coat protein (subunit VP3)	3	protein	238	Human rhinovirus 1A	P23008 (AlphaFold model)
Human rhinovirus 1A coat protein (subunit VP4)	4	protein	44	Human rhinovirus 1A	P23008 (AlphaFold model)

Sequence of entity 1 (1), FASTA

>1R1A_1 HUMAN RHINOVIRUS 1A COAT PROTEIN (SUBUNIT VP1) (chains 1)
NPVENYIDEVLNEVLVVPNIKESHHTTSNSAPLLDAAETGHTSNVQPEDAIETRYVITSQ
TRDEMSIESFLGRSGCVHISRIKVDYTDYNGQDINFTKWKITLQEMAQIRRKFELFTYVR
FDSEITLVPCIAGRGDDIGHIVMQYMYVPPGAPIPSKRNDFSWQSGTNMSIFWQHGQPFP
RFSIPFLSIASAYYMFYDGYDGDNTSSKYGSVVTNDMGTICSRIVTEKQKLSVVITTHIY
HKAKHTKAWCPRPPRAVPYTHSHVTNYMPETGDVTTAIVRRNTITTA

Sequence of entity 2 (2), FASTA

>1R1A_2 HUMAN RHINOVIRUS 1A COAT PROTEIN (SUBUNIT VP2) (chains 2)
SPSVEACGYSDRIMQITRGDSTISSDDVANAVVGYGVWPHYLTPQDATAINKPTQPDTSS
NRFYTLESKHWNGSSKGWWWKLPDALKDMGIFGENMYYHFLGRSGYTVHVQCNASKFHQG
TLLVAMIPEHQLASAKHGSVTAGYKLTHPGEAGRDVSQERDASLRQPSDDSWLNFDGTLL
GNLLIFPHQFINLRSNNSATLIVPYVNAVPMDSMLRHNNWCLVIIPISPLRSETTSSNIV
PITVSISPMCAEFSGARAKNIKQ

Sequence of entity 3 (3), FASTA

>1R1A_3 HUMAN RHINOVIRUS 1A COAT PROTEIN (SUBUNIT VP3) (chains 3)
GLPVYITPGSGQFMTTDDMQSPCALPWYHPTKEISIPGEVKNLIEMCQVDTLIPVNNVGN
NVGNVSMYTVQLGNQTGMAQKVFSIKVDITSTPLATTLIGEIASYYTHWTGSLRFSFMFC
GTANTTLKLLLAYTPPGIDEPTTRKDAMLGTHVVWDVGLQSTISLVVPWVSASHFRLTAD
NKYSMAGYITCWYQTNLVVPPSTPQTADMLCFVSACKDFCLRMARDTDLHIQSGPIEQ

Sequence of entity 4 (4), FASTA

>1R1A_4 HUMAN RHINOVIRUS 1A COAT PROTEIN (SUBUNIT VP4) (chains 4)
GAGVSRQNVGTHSTQNSVSNGSSLNYFNINYFKDAASSGASRLD

Primary citation

Crystal structure of human rhinovirus serotype 1A (HRV1A). Kim, S.S., Smith, T.J., Chapman, M.S. et al. J Mol Biol (1989) 210:91-111. DOI 10.1016/0022-2836(89)90293-3 · PubMed

Other PDB entries of the same protein (UniProt P23008 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1AYM 2.15 Å, Human rhinovirus 16 coat protein at high resolution
1AYN 2.9 Å, Human rhinovirus 16 coat protein
2HWD 3.8 Å, A comparison of the anti-rhinoviral drug binding pocket in HRV14 and HRV1A
2HWE 3.8 Å, A comparison of the anti-rhinoviral drug binding pocket in HRV14 and HRV1A
2HWF 3.8 Å, A comparison of the anti-rhinoviral drug binding pocket in HRV14 and HRV1A

Browse structure collections

About this viewer

MolViewer shows 1R1A directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.