1SU4: Calcium ATPase with two bound calcium ions

Crystal structure of calcium ATPase with two bound calcium ions. Determined by X-ray diffraction at 2.4 Å resolution. Released 4 May 2004.

Method: X-ray diffraction
Resolution: 2.4 Å
Organism: Oryctolagus cuniculus
Chains: 1
Atoms: 7,791
Mol. weight: 109.71 kDa
Ligands: CA
Released: 4 May 2004

Explore 1SU4 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1SU4 contains 57 α-helices and 36 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 57 helices, 36 β-strands

Element	Residues	Length	Sheet
α-helix	9-15	7
β-strand	24	1	1
α-helix	26-36	11
α-helix	41-45	5
α-helix	49-50	2
α-helix	51-56	6
α-helix	57-78	22
α-helix	86-117	32
α-helix	120-122	3
β-strand	128-130	3	2
β-strand	131	1	1
β-strand	138-139	2	2
α-helix	142-144	3
β-strand	150-153	4	2
β-strand	158	1	3
β-strand	162-168	7	2
β-strand	174-176	3	3
β-strand	187-188	2	3
α-helix	201-203	3
β-strand	207-208	2	2
β-strand	213-216	4	3
β-strand	219-225	7	2
α-helix	227-229	3
α-helix	248-273	26
α-helix	276-278	3
α-helix	282-284	3
α-helix	290-306	17
α-helix	311-328	18
β-strand	331-332	2	4
α-helix	337-343	7
β-strand	347-351	5	4
β-strand	353	1	5
β-strand	357	1	5
β-strand	362-373	12	6
β-strand	376-384	9	6
β-strand	395-397	3	6
β-strand	400-401	2	6
α-helix	404-406	3
α-helix	408-419	12
β-strand	424-428	5	7
β-strand	433-437	5	7
α-helix	440-452	13
α-helix	464-467	4
α-helix	470-478	9
β-strand	479-488	10	6
β-strand	493-500	8	6
β-strand	511-516	6	6
α-helix	518-523	6
β-strand	525-530	6	6
β-strand	533-536	4	6
α-helix	539-554	16
β-strand	560-567	8	6
α-helix	570-572	3
α-helix	573-575	3
α-helix	581-583	3
α-helix	584-587	4
β-strand	591-600	10	6
α-helix	602	1
β-strand	603	1	5
α-helix	604	1
α-helix	607-616	10
β-strand	620-625	6	4
α-helix	629-639	11
β-strand	652-654	3	4
α-helix	655-659	5
α-helix	663-672	10
β-strand	675-677	3	4
α-helix	681-692	12
β-strand	698-702	5	4
α-helix	705-707	3
α-helix	708-713	6
β-strand	716-720	5	4
α-helix	725-729	5
β-strand	733-735	3	4
α-helix	740-781	42
α-helix	783-785	3
α-helix	789-799	11
α-helix	802-807	6
α-helix	810-812	3
α-helix	820-823	4
α-helix	831-856	26
α-helix	873-875	3
α-helix	880-882	3
α-helix	888-892	5
α-helix	894-911	18
α-helix	913-915	3
α-helix	927-929	3
α-helix	931-949	19
α-helix	952-956	5
α-helix	961-963	3
α-helix	964-974	11
α-helix	976-986	11
α-helix	987-992	6

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	A	protein	994	Oryctolagus cuniculus	P04191 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>1SU4_1 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (chains A)
MEAAHSKSTEECLAYFGVSETTGLTPDQVKRHLEKYGHNELPAEEGKSLWELVIEQFEDL
LVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILIANAIVGVWQERNAENAIEALK
EYEPEMGKVYRADRKSVQRIKARDIVPGDIVEVAVGDKVPADIRILSIKSTTLRVDQSIL
TGESVSVIKHTEPVPDPRAVNQDKKNMLFSGTNIAAGKALGIVATTGVSTEIGKIRDQMA
ATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWIRGAIYYFKIAV
ALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQ
MSVCKMFIIDKVDGDFCSLNEFSITGSTYAPEGEVLKNDKPIRSGQFDGLVELATICALC
NDSSLDFNETKGVYEKVGEATETALTTLVEKMNVFNTEVRNLSKVERANACNSVIRQLMK
KEFTLEFSRDRKSMSVYCSPAKSSRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPMTGP
VKEKILSVIKEWGTGRDTLRCLALATRDTPPKREEMVLDDSSRFMEYETDLTFVGVVGML
DPPRKEVMGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEEVADRAYTGREFDD
LPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAM
GSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAA
LGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAI
GGYVGAATVGAAAWWFMYAEDGPGVTYHQLTHFMQCTEDHPHFEGLDCEIFEAPEPMTMA
LSVLVTIEMCNALNSLSENQSLMRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLK
ALDLTQWLMVLKISLPVIGLDEILKFIARNYLEG

Ligands and cofactors

ID	Name	Formula	Copies
CA	Calcium ion	Ca	2

Water and common crystallization additives (NA) are not listed.

Primary citation

Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 A resolution. Toyoshima, C., Nakasako, M., Nomura, H. et al. Nature (2000) 405:647-655. DOI 10.1038/35015017 · PubMed

Other PDB entries of the same protein (UniProt P04191 (AlphaFold model), which also has an AlphaFold model), best resolution first:

27RD 2.0 Å, Crystal structure of SR Ca2+-ATPase in E2(TG) with bound IPP
27QZ 2.1 Å, Crystal structure of SR Ca2+-ATPase in E2(TG) with bound B1HQ
27RC 2.1 Å, Crystal structure of SR Ca2+-ATPase in E2(TG) with bound BMP
27QY 2.12 Å, Crystal structure of SR Ca2+-ATPase in E2(TG) with bound AHQ
3AR4 2.15 Å, Calcium pump crystal structure with bound ATP and TG in the absence of Ca2+
3AR7 2.15 Å, Calcium pump crystal structure with bound TNP-ATP and TG in the absence of Ca2+
27RE 2.2 Å, Crystal structure of SR Ca2+-ATPase in E2(TG) with bound MPQ
27RF 2.2 Å, Crystal structure of SR Ca2+-ATPase in E2(TG) with bound PHQ
3AR5 2.2 Å, Calcium pump crystal structure with bound TNP-AMP and TG
3AR6 2.2 Å, Calcium pump crystal structure with bound TNP-ADP and TG in the absence of calcium
3N5K 2.2 Å, Structure Of The (Sr)Ca2+-ATPase E2-AlF4- Form
1WPG 2.3 Å, Crystal structure of the SR CA2+-ATPase with MGF4

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1SU4 is part of these collections:

Membrane proteins and transporters

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