1WA5: Cse1:Imp-alpha:RanGTP complex

Structure of the Cse1:Imp-alpha:RanGTP complex. Determined by X-ray diffraction at 2.0 Å resolution. Released 13 Dec 2004.

Method
X-ray diffraction
Resolution
2.0 Å
Organisms
Canis lupus familiaris, Saccharomyces cerevisiae
Chains
3
Atoms
13,522
Mol. weight
189.28 kDa
Ligands
MG, GTP
Released
13 Dec 2004

Explore 1WA5 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1WA5 contains 116 α-helices and 14 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 6 β-strands

ElementResiduesLengthSheet
β-strand9-1791
α-helix23-3210
α-helix34-363
β-strand45-55111
β-strand57-66101
α-helix70-723
α-helix76-805
β-strand85-9171
α-helix95-995
α-helix101-11111
β-strand117-12261
α-helix138-1425
β-strand145-14841
α-helix159-16911
Chain B: 37 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix15-173
α-helix45-462
α-helix51-522
α-helix89-979
α-helix101-11515
α-helix123-1286
α-helix132-1376
α-helix145-15814
α-helix163-1719
α-helix175-18410
α-helix187-20115
α-helix205-2139
α-helix217-2226
α-helix223-2253
α-helix229-24315
α-helix249-2502
α-helix252-2554
α-helix256-2583
α-helix259-2657
α-helix271-28414
α-helix289-2979
α-helix301-3066
α-helix307-3093
α-helix313-32614
α-helix331-3399
α-helix342-3498
α-helix355-36915
α-helix373-3819
α-helix385-39410
α-helix397-41317
α-helix418-4269
α-helix430-4367
α-helix442-46625
α-helix472-4798
α-helix482-4887
α-helix489-4913
α-helix495-50814
Chain C: 71 helices, 8 β-strands
ElementResiduesLengthSheet
α-helix3-1311
α-helix17-193
α-helix20-3011
α-helix36-4510
α-helix51-6818
β-strand7012
β-strand7612
α-helix80-9617
α-helix99-11618
α-helix124-1296
α-helix137-15115
α-helix152-1543
α-helix158-1592
α-helix161-19131
α-helix196-21520
α-helix223-2275
α-helix229-24113
α-helix245-2473
α-helix258-27619
α-helix278-29720
α-helix303-3053
α-helix306-32015
α-helix323-3264
α-helix327-3293
α-helix332-3387
α-helix339-3435
α-helix344-3474
α-helix351-3599
α-helix361-37010
α-helix377-39115
α-helix393-41321
α-helix419-43315
β-strand43413
β-strand43914
β-strand44214
β-strand44613
α-helix452-4554
α-helix456-4605
α-helix461-4655
α-helix472-48413
α-helix486-4883
α-helix491-50414
α-helix510-52314
β-strand527-52935
β-strand532-53545
α-helix539-5413
α-helix546-55712
α-helix564-5674
α-helix571-58414
α-helix589-5913
α-helix592-60615
α-helix613-62816
α-helix632-6343
α-helix635-65117
α-helix658-67114
α-helix680-6823
α-helix685-6873
α-helix689-6924
α-helix698-71215
α-helix713-7153
α-helix720-73011
α-helix736-74914
α-helix752-7554
α-helix756-7583
α-helix759-77214
α-helix776-79217
α-helix795-8039
α-helix809-8135
α-helix814-8185
α-helix819-8213
α-helix822-8243
α-helix828-84316
α-helix846-8516
α-helix855-86814
α-helix899-9013
α-helix917-93216
α-helix937-9415
α-helix942-9443
α-helix947-95711

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
GTP-binding nuclear protein RanAprotein176Canis lupus familiarisP62825 (AlphaFold model)
SRP1 isoform 1Bprotein530Saccharomyces cerevisiaeQ02821 (AlphaFold model)
Importin alpha re-exporterCprotein960Saccharomyces cerevisiaeP33307 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>1WA5_1 GTP-binding nuclear protein Ran (chains A)
MAAQGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIK
FNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLC
GNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEF
Sequence of entity 2 (B), FASTA
>1WA5_2 SRP1 isoform 1 (chains B)
MDNGTDSSTSKFVPEYRRTNFKNKGRFSADELRRRRDTQQVELRKAKRDEALAKRRNFIP
PTDGADSDEEDESSVSADQQFYSQLQQELPQMTQQLNSDDMQEQLSATVKFRQILSQEHR
PPIDVVIQAGVVPRLVEFMRENQPEMLQLEAAWALTNIASGTSAQTKVVVDADAVPLFIQ
LLYTGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKPSLIRTATWTLS
NLCRGKKPQPDWSVVSQALPTLAKLIYSMDTETLVDACWAISYLSDGPQEAIQAVIDVRI
PKRLVELLSHESTLVQTPALRAVGNIVTGNDLQTQVVINAGVLPALRLLLSSPKENIKKE
ACWTISNITAGNTEQIQAVIDANLIPPLVKLLEVAEYKTKKEACWAISNASSGGLQRPDI
IRYLVSQGCIKPLCDLLEIADNRIIEVTLDALENILKMGEADKEARGLNINENADFIEKA
GGMEKIFNCQQNENDKIYEKAYKIIETYFGEEEDAVDETMAPQNAGNTFG
Sequence of entity 3 (C), FASTA
>1WA5_3 Importin alpha re-exporter (chains C)
MSDLETVAKFLAESVIASTAKTSERNLRQLETQDGFGLTLLHVIASTNLPLSTRLAGALF
FKNFIKRKWVDENGNHLLPANNVELIKKEIVPLMISLPNNLQVQIGEAISSIADSDFPDR
WPTLLSDLASRLSNDDMVTNKGVLTVAHSIFKRWRPLFRSDELFLEIKLVLDVFTAPFLN
LLKTVDEQITANENNKASLNILFDVLLVLIKLYYDFNCQDIPEFFEDNIQVGMGIFHKYL
SYSNPLLEDPDETEHASVLIKVKSSIQELVQLYTTRYEDVFGPMINEFIQITWNLLTSIS
NQPKYDILVSKSLSFLTAVTRIPKYFEIFNNESAMNNITEQIILPNVTLREEDVELFEDD
PIEYIRRDLEGSDTDTRRRACTDFLKELKEKNEVLVTNIFLAHMKGFVDQYMSDPSKNWK
FKDLYIYLFTALAINGNITNAGVSSTNNLLNVVDFFTKEIAPDLTSNNIPHIILRVDAIK
YIYTFRNQLTKAQLIELMPILATFLQTDEYVVYTYAAITIEKILTIRESNTSPAFIFHKE
DISNSTEILLKNLIALILKHGSSPEKLAENEFLMRSIFRVLQTSEDSIQPLFPQLLAQFI
EIVTIMAKNPSNPRFTHYTFESIGAILNYTQRQNLPLLVDSMMPTFLTVFSEDIQEFIPY
VFQIIAFVVEQSATIPESIKPLAQPLLAPNVWELKGNIPAVTRLLKSFIKTDSSIFPDLV
PVLGIFQRLIASKAYEVHGFDLLEHIMLLIDMNRLRPYIKQIAVLLLQRLQNSKTERYVK
KLTVFFGLISNKLGSDFLIHFIDEVQDGLFQQIWGNFIITTLPTIGNLLDRKIALIGVLN
MVINGQFFQSKYPTLISSTMNSIIETASSQSIANLKNDYVDLDNLEEISTFGSHFSKLVS
ISEKPFDPLPEIDVNNGVRLYVAEALNKYNAISGNTFLNTILPQLTQENQVKLNQLLVGN

Ligands and cofactors

IDNameFormulaCopies
MGMagnesium ionMg1
GTPGuanosine-5'-triphosphateC10 H16 N5 O14 P31

Primary citation

Structural basis for the assembly of a nuclear export complex. Matsuura, Y., Stewart, M. Nature (2004) 432:872-877. DOI 10.1038/NATURE03144

Other PDB entries of the same protein (UniProt P62825 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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