1WR6: GGA3 GAT domain

Crystal structure of GGA3 GAT domain in complex with ubiquitin. Determined by X-ray diffraction at 2.6 Å resolution. Released 28 Jun 2005.

Method: X-ray diffraction
Resolution: 2.6 Å
Organisms: Homo sapiens, Bos taurus
Chains: 8
Atoms: 5,327
Mol. weight: 85.13 kDa
Released: 28 Jun 2005

Explore 1WR6 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

1WR6 contains 26 α-helices and 28 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 4 helices, 0 β-strands

Element	Residues	Length
α-helix	218-231	14
α-helix	242-267	26
α-helix	276-290	15
α-helix	292-295	4

Chain B: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	218-233	16
α-helix	242-267	26
α-helix	276-296	21

Chain C: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	218-233	16
α-helix	242-267	26
α-helix	275-296	22

Chain D: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	218-233	16
α-helix	242-268	27
α-helix	276-296	21

Chain E: 2 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	2-6	5	1
β-strand	12-16	5	1
β-strand	22	1	2
α-helix	23-34	12
α-helix	38-40	3
β-strand	43-45	3	1
β-strand	48-49	2	1
β-strand	55	1	2
β-strand	66-69	4	1

Chain F: 3 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	2-7	6	3
β-strand	12-16	5	3
β-strand	22	1	4
α-helix	23-34	12
α-helix	38-40	3
β-strand	43-45	3	3
β-strand	48-49	2	3
α-helix	50-51	2
β-strand	55	1	4
β-strand	66-69	4	3

Chain G: 4 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	2-6	5	5
β-strand	12-16	5	5
β-strand	22	1	6
α-helix	23-34	12
α-helix	38-40	3
β-strand	41-45	5	5
β-strand	48-49	2	5
α-helix	50-51	2
β-strand	55	1	6
α-helix	56-59	4
β-strand	66-71	6	5

Chain H: 4 helices, 7 β-strands

Element	Residues	Length	Sheet
β-strand	2-6	5	7
β-strand	12-16	5	7
β-strand	22	1	8
α-helix	23-34	12
α-helix	38-40	3
β-strand	41-45	5	7
β-strand	48-49	2	7
α-helix	50-51	2
β-strand	55	1	8
β-strand	66-71	6	7
α-helix	72-73	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
ADP-ribosylation factor binding protein GGA3	A, B, C, D	protein	111	Homo sapiens	Q9NZ52 (AlphaFold model)
ubiquitin	E, F, G, H	protein	76	Bos taurus	P0CH28 (AlphaFold model)

Sequence of entity 1 (A, B, C, D), FASTA

>1WR6_1 ADP-ribosylation factor binding protein GGA3 (chains A, B, C, D)
QKVTKRLHTLEEVNNNVRLLSEMLLHYSQEDSSDGDRELMKELFDQCENKRRTLFKLASE
TEDNDNSLGDILQASDNLSRVINSYKTIIEGQVINGEVATLTLPDSEGNSQ

Sequence of entity 2 (E, F, G, H), FASTA

>1WR6_2 ubiquitin (chains E, F, G, H)
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYN
IQKESTLHLVLRLRGG

Primary citation

Molecular mechanism of ubiquitin recognition by GGA3 GAT domain. Kawasaki, M., Shiba, T., Shiba, Y. et al. Genes Cells (2005) 10:639-654. DOI 10.1111/j.1365-2443.2005.00865.x · PubMed

Other PDB entries of the same protein (UniProt Q9NZ52 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1JUQ 2.2 Å, GGA3 VHS domain complexed with C-terminal peptide from cation-dependent Mannose…
1P4U 2.2 Å, Crystal structure of GGA3 gae domain in complex with rabaptin-5 peptide
1LF8 2.3 Å, Complex of GGA3-VHS Domain and CI-MPR C-terminal Phosphopeptide
1JPL 2.4 Å, GGA3 VHS domain complexed with C-terminal peptide from cation-independent mannose…
1YD8 2.8 Å, Complex of human GGA3 gat domain and ubiquitin

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