Protease domain of HGFA with no inhibitor. Determined by X-ray diffraction at 2.7 Å resolution. Released 15 Feb 2005.
Explore 1YBW in 3D Show helices and sheets RCSB PDB PDBe
1YBW contains 22 α-helices and 42 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 409 | 1 | 1 |
| β-strand | 412-413 | 2 | 2 |
| α-helix | 414-415 | 2 | |
| β-strand | 422-427 | 6 | 3 |
| β-strand | 430-438 | 9 | 3 |
| β-strand | 441-444 | 4 | 3 |
| α-helix | 446-448 | 3 | |
| α-helix | 455-457 | 3 | |
| β-strand | 458-462 | 5 | 3 |
| β-strand | 466 | 1 | 4 |
| β-strand | 475-477 | 3 | 3 |
| β-strand | 479-484 | 6 | 3 |
| β-strand | 489 | 1 | 5 |
| β-strand | 492 | 1 | 5 |
| β-strand | 499-503 | 5 | 3 |
| α-helix | 504-505 | 2 | |
| α-helix | 512-513 | 2 | |
| α-helix | 519-520 | 2 | |
| β-strand | 521 | 1 | 2 |
| α-helix | 522 | 1 | |
| β-strand | 534-539 | 6 | 2 |
| β-strand | 553 | 1 | 4 |
| β-strand | 555-561 | 7 | 2 |
| α-helix | 562-563 | 2 | |
| α-helix | 564-568 | 5 | |
| β-strand | 581-584 | 4 | 2 |
| β-strand | 592 | 1 | 1 |
| β-strand | 601-606 | 6 | 2 |
| β-strand | 609-616 | 8 | 2 |
| β-strand | 629-633 | 5 | 2 |
| α-helix | 634-637 | 4 | |
| α-helix | 638-642 | 5 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Hepatocyte growth factor activator precursor | A, B | protein | 283 | Homo sapiens | Q04756 (AlphaFold model) |
>1YBW_1 Hepatocyte growth factor activator precursor (chains A, B) VQLSPDLLATLPEPASPGRQACGRRHKKRTFLRPRIIGGSSSLPGSHPWLAAIYIGDSFC AGSLVHTCWVVSAAHCFSHSPPRDSVSVVLGQHFFNRTTDVTQTFGIEKYIPYTLYSVFN PSDHDLVLIRLKKKGDRCATRSQFVQPICLPEPGSTFPAGHKCQIAGWGHLDENVSGYSS SLREALVPLVADHKCSSPEVYGADISPNMLCAGYFDCKSDACQGDSGGPLACEKNGVAYL YGIISWGDGCGRLHKPGVYTRVANYVDWINDRIRPPRRLVAPS
| ID | Name | Formula | Copies |
|---|---|---|---|
| NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose | C8 H15 N O6 | 2 |
Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B. Shia, S., Stamos, J., Kirchhofer, D. et al. J Mol Biol (2005) 346:1335-1349. DOI 10.1016/j.jmb.2004.12.048 · PubMed
Other PDB entries of the same protein (UniProt Q04756 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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