KCNQ2/3 heterotetramer with 2:2 stoichiometry. Determined by electron microscopy at 2.7 Å resolution. Released 3 Jun 2026.
Explore 22BK in 3D Show helices and sheets RCSB PDB PDBe
22BK contains 61 α-helices and 0 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 72-86 | 15 | |
| α-helix | 90-92 | 3 | |
| α-helix | 93-114 | 22 | |
| α-helix | 119-147 | 29 | |
| α-helix | 148-150 | 3 | |
| α-helix | 157-164 | 8 | |
| α-helix | 167-183 | 17 | |
| α-helix | 196-204 | 9 | |
| α-helix | 205-211 | 7 | |
| α-helix | 213-215 | 3 | |
| α-helix | 216-227 | 12 | |
| α-helix | 229-254 | 26 | |
| α-helix | 264-275 | 12 | |
| α-helix | 288-305 | 18 | |
| α-helix | 307-327 | 21 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 104-116 | 13 | |
| α-helix | 121-142 | 22 | |
| α-helix | 149-176 | 28 | |
| α-helix | 177-179 | 3 | |
| α-helix | 187-192 | 6 | |
| α-helix | 193-195 | 3 | |
| α-helix | 197-209 | 13 | |
| α-helix | 222-226 | 5 | |
| α-helix | 231-238 | 8 | |
| α-helix | 245-256 | 12 | |
| α-helix | 258-281 | 24 | |
| α-helix | 296-298 | 3 | |
| α-helix | 303-314 | 12 | |
| α-helix | 327-344 | 18 | |
| α-helix | 346-365 | 20 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 71-86 | 16 | |
| α-helix | 90-92 | 3 | |
| α-helix | 93-113 | 21 | |
| α-helix | 119-147 | 29 | |
| α-helix | 148-150 | 3 | |
| α-helix | 152-154 | 3 | |
| α-helix | 157-163 | 7 | |
| α-helix | 167-183 | 17 | |
| α-helix | 196-204 | 9 | |
| α-helix | 205-209 | 5 | |
| α-helix | 213-215 | 3 | |
| α-helix | 216-225 | 10 | |
| α-helix | 229-254 | 26 | |
| α-helix | 264-275 | 12 | |
| α-helix | 288-305 | 18 | |
| α-helix | 307-326 | 20 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily KQT member 2 | A, C | protein | 872 | Homo sapiens | O43526 (AlphaFold model) |
| Potassium voltage-gated channel subfamily KQT member 3 | B, D | protein | 872 | Homo sapiens | O43525 (AlphaFold model) |
>22BK_1 Potassium voltage-gated channel subfamily KQT member 2 (chains A, C) MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEK SSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASI AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGF LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLI GVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTW QYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSKGSP CRGPLCGCCPGRSSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKV PKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSI RAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPAIT DKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYFG AKEPEPAPPYHSPEDSREHVDRHGCIVKIVRSSSSTGQKNFSAPPAAPPVQCPPSTSWQP QSHPRQGHGTSPVGDHGSLVRIPPPPAHERSLSAYGGGNRASMEFLRQEDTPGCRPPEGN LRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNSCYAAVAPCAKVRPYIAEGESD TDSDLCTPCGPPPRSATGEGPFGDVGWAGPRK
>22BK_2 Potassium voltage-gated channel subfamily KQT member 3 (chains B, D) MGLKARRAAGAAGGGGDGGGGGGGAANPAGGDAAAAGDEERKVGLAPGDVEQVTLALGAG ADKDGTLLLEGGGRDEGQRRTPQGIGLLAKTPLSRPVKRNNAKYRRIQTLIYDALERPRG WALLYHALVFLIVLGCLILAVLTTFKEYETVSGDWLLLLETFAIFIFGAEFALRIWAAGC CCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVLATSLRSLRFLQILRMLRM DRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLVYLVEKDVPEVDAQGEEMKEEF ETYADALWWGLITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQ EQHRQKHFEKRRKPAAELIQAAWRYYATNPNRIDLVATWRFYESVVSFPFFRKEQLEAAS SQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEESPSKEPKPVGLNNKERFRTAFRMKA YAFWQSSEDAGTGDPMAEDRGYGNDFPIEDMIPTLKAAIRAVRILQFRLYKKKFKETLRP YDVKDVIEQYSAGHLDMLSRIKYLQTRIDMIFTPGPPSTPKHKKSQKGSAFTFPSQQSPR NEPYVARPSTSEIEDQSMMGKFVKVERQVQDMGKKLDFLVDMHMQHMERLQVQVTEYYPT KGTSSPAEAEKKEDNRYSDLKTIICNYSETGPPEPPYSFHQVTIDKVSPYGFFAHDPVNL PRGGPSSGKVQATPPSSATTYVERPTVLPILTLLDSRVSCHSQADLQGPYSDRISPRQRR SITRDSDTPLSLMSVNHEELERSPSGFSISQDRDDYVFGPNGGSSWMREKRYLAEGETDT DTDPFTPSGSMPLSSTGDGISDSVWTPSNKPI
Structural basis for the assembly and modulation of human M-channels. Lu, F., Huang, X., Cai, G. et al. To be published.
Other PDB entries of the same protein (UniProt O43526 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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