24KK: Second bromodomain (BD2) of human BRD2

Crystal structure of the second bromodomain (BD2) of human BRD2 in complex with Mefanamic acid. Determined by X-ray diffraction at 1.2 Å resolution. Released 29 Jul 2026.

Method: X-ray diffraction
Resolution: 1.2 Å
Organism: Homo sapiens
Chains: 1
Atoms: 1,234
Mol. weight: 13.53 kDa
Ligands: ID8
Released: 29 Jul 2026

Explore 24KK in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

24KK contains 8 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 0 β-strands

Element	Residues	Length
α-helix	346-360	15
α-helix	363-365	3
α-helix	366-369	4
α-helix	370-372	3
α-helix	386-389	4
α-helix	396-404	9
α-helix	411-428	18
α-helix	434-450	17

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Bromodomain-containing protein 2	A	protein	114	Homo sapiens	P25440 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>24KK_1 Bromodomain-containing protein 2 (chains A)
AAHGSNPEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVK
RKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMP

Ligands and cofactors

ID	Name	Formula	Copies
ID8	2-[(2,3-dimethylphenyl)amino]benzoic acid	C15 H15 N O2	1

Primary citation

BET Bromodomain Targeting by NSAIDs: Structural, Biophysical, and Computational Insights. Sridhar, A., Kandhasami, N., Mathur, S. et al. Proteins (2026). DOI 10.1002/prot.70154 · PubMed

Other PDB entries of the same protein (UniProt P25440 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5IG6 0.91 Å, Ultra-high resolution crystal structure of second bromodomain of BRD2 in complex with…
5IBN 0.94 Å, Ultra high resolution crystal structure of the apo- form of second bromodomain of BRD2.
6DBC 1.05 Å, Second bromodomain of Human BRD2 with a Tetrahydroquinoline analogue
6DDJ 1.05 Å, Crystal Structure of the human BRD2 BD2 bromodimain in complex with a…
4J1P 1.08 Å, X-ray crystal structure of bromodomain 2 of human brd2 in complex with rvx208 to 1.08 A…
7VRM 1.1 Å, crystal structure of BRD2-BD2 in complex with purine derivative
6I80 1.14 Å, Crystal Structure of the second bromodomain of BRD2 in complex with RT53
7VRQ 1.15 Å, crystal structure of BRD2-BD2 in complex with purine derivative
5O38 1.2 Å, Human Brd2(BD2) mutant in free form
5O3I 1.2 Å, Human Brd2(BD2) mutant in complex with AL-tBu
7USG 1.2 Å, BRD2-BD2 in complex with MDP5
7VS0 1.25 Å, crystal structure of BRD2-BD2 in complex with purine derivative

Browse structure collections

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