27PT: Dynein heavy chain, cytoplasmic

Dictyostelium discoideum cytoplasmic dynein motor domain in complex with ADP.Vi (Phi-particle). Determined by electron microscopy at 2.2 Å resolution. Released 26 Aug 2026.

Method
Electron microscopy
Resolution
2.2 Å
Organism
Dictyostelium discoideum AX2
Chains
1
Atoms
23,823
Mol. weight
386.29 kDa
Ligands
AOV, MG, ATP, ADP
Released
26 Aug 2026

Explore 27PT in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

27PT contains 164 α-helices and 71 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 164 helices, 71 β-strands

ElementResiduesLengthSheet
α-helix1514-153926
β-strand154211
β-strand1545-154842
β-strand1552-155542
α-helix1558-157417
α-helix1575-15773
α-helix1588-161932
α-helix1624-16285
α-helix1630-165122
β-strand165511
α-helix1656-16616
α-helix1665-169026
α-helix1695-16995
α-helix1702-17109
α-helix1715-17173
α-helix1719-17213
α-helix1722-17254
β-strand1731-173443
β-strand1740-174563
β-strand1751-175993
α-helix1766-179227
α-helix1800-18089
α-helix1812-183120
α-helix1838-186326
α-helix1869-189325
α-helix1904-19074
β-strand1911-191444
α-helix1921-19233
β-strand1925-192954
β-strand1932-193544
α-helix1951-196515
β-strand1969-197355
α-helix1980-199011
β-strand1995-199955
α-helix2006-201914
β-strand2022-202655
α-helix2028-20303
α-helix2033-205119
β-strand2056-206056
β-strand2063-206646
β-strand2072-207765
α-helix2085-20884
α-helix2089-20924
β-strand2095-209955
α-helix2105-211511
α-helix2121-213818
α-helix2149-216517
α-helix2168-21736
α-helix2179-220224
α-helix2204-22063
α-helix2209-22113
α-helix2212-222211
α-helix2230-22323
α-helix2234-224613
α-helix2253-226816
β-strand2271-227557
α-helix2282-229716
β-strand2301-230667
α-helix2313-23175
β-strand2318-232038
β-strand2327-232938
α-helix2331-234111
α-helix2346-23483
β-strand2350-235677
α-helix2361-23644
α-helix2365-23673
α-helix2368-23714
β-strand2376-237839
β-strand2384-238639
α-helix2387-23882
β-strand2391-239777
α-helix2405-24106
β-strand2412-241547
α-helix2423-243614
α-helix2441-245919
α-helix2490-250213
α-helix2503-25064
α-helix2511-252010
α-helix2530-255425
α-helix2559-25613
α-helix2562-258221
α-helix2587-260014
α-helix2612-26143
β-strand2615-2617310
β-strand2624-2626310
α-helix2627-26304
α-helix2638-26403
α-helix2651-266515
β-strand2671-2673311
α-helix2680-26889
β-strand2694-2700711
α-helix2707-271711
β-strand2718-2722512
β-strand2728-2732512
β-strand2738-2744711
α-helix2750-27512
α-helix2758-276811
β-strand2771-2774412
β-strand2779-2783512
β-strand2786-2792711
α-helix2802-28043
α-helix2805-28084
β-strand2813-2815311
α-helix2821-283616
α-helix2840-28423
α-helix2846-286318
α-helix2876-289015
α-helix2898-291316
α-helix2920-293718
α-helix2943-29464
α-helix29471
α-helix29491
β-strand2952-2953213
β-strand2961-2962213
α-helix2965-298218
α-helix2992-300514
β-strand3012-3015414
α-helix3022-303211
β-strand3036-3038314
α-helix3048-306316
β-strand3069-3074614
α-helix3075-30773
α-helix3081-309313
α-helix3103-311816
α-helix3126-314015
β-strand3141-3147714
α-helix3154-31563
α-helix3163-31664
β-strand3169-3172414
α-helix31741
α-helix3176-31772
α-helix3178-318811
α-helix3203-321210
α-helix3223-324927
α-helix3257-331357
α-helix3546-356621
α-helix3568-358619
α-helix3588-360114
α-helix3602-36043
α-helix3607-362317
α-helix3634-36385
α-helix3641-36499
α-helix3656-36649
α-helix36711
β-strand3672-3675415
α-helix3680-36889
α-helix3690-36923
β-strand3695-3698415
α-helix3704-371411
β-strand3717-3721515
α-helix3723-37253
α-helix3728-37303
α-helix3731-37355
β-strand3738-3741416
β-strand3744-3748516
β-strand3753-3755316
β-strand3761-3766615
α-helix3775-37806
β-strand3782-3785415
α-helix3790-380516
α-helix3807-383933
α-helix3849-388335
α-helix3887-390216
α-helix3903-39053
α-helix3913-392513
α-helix3928-39303
α-helix3936-395520
α-helix3961-397616
α-helix3982-39843
α-helix3985-39939
α-helix3998-40003
α-helix4006-40083
α-helix4014-402613
α-helix4028-40303
α-helix4033-40397
α-helix4041-40488
α-helix4060-406910
α-helix4075-408814
α-helix4094-410613
α-helix4118-41203
α-helix4121-41255
β-strand4132-4136517
α-helix4143-415311
β-strand4157-4161517
β-strand4162118
β-strand4164118
α-helix4167-418115
β-strand4184-4188517
α-helix4190-41923
α-helix4194-420512
β-strand4214-4220717
α-helix4227-42326
β-strand4234-4238517
α-helix4244-425310
α-helix4257-42604
α-helix4266-428419
α-helix4285-42873
α-helix4300-431819
α-helix4326-43283
α-helix4331-43377
α-helix4338-43425
α-helix4344-43463
α-helix4350-436314
α-helix4366-43694
β-strand4374-4376319
α-helix4377-43793
β-strand4381-4382219
α-helix4389-43979
α-helix4405-44084
α-helix4412-44143
α-helix4416-443419
α-helix4453-44575
α-helix4463-447614
α-helix4477-448610
α-helix4490-44923
α-helix4494-452532
α-helix4532-454211
α-helix4561-457111
α-helix45741
α-helix4575-45795
α-helix4584-45863
β-strand4589-4590220
α-helix4597-461216
α-helix4616-46183
β-strand4619-4626820
β-strand4636-4640520
β-strand4647-4650421
β-strand4653-4656421
β-strand4667-4673720
α-helix4677-46848
β-strand4686-4691622
β-strand4699-4705722
β-strand4707121
α-helix4713-47186
β-strand4723-4724222

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Dynein heavy chain, cytoplasmicAprotein3367Dictyostelium discoideum AX2P34036
Sequence of entity 1 (A), FASTA
>27PT_1 Dynein heavy chain, cytoplasmic (chains A)
MTRHHHHHHGGGDYKDDDDKGGGKVPVEEEIQDLKAVWVELSNTWQEIDSLKETAWSAII
PRKVRKSLEDTLQKLKNLPNRIRQYSAFDHAQNLIKIYLKGNAIITDLHSEAIKDRHWKI
LKKRLNTNWIITELTLGSIWDSDLARNENIYREVITAAQGEIALEEFLKGVREFWTTLEL
DLVNYQRKCKLVRGWDDLFNKLAEHLNSISAMKMSPYYKVFEEEANHWDDRLNKVRSLLD
VWIDVQRRWVYLEGIFSGSGDINQLLPAESTRFKSINSEFIAILKKVSGAPLILEVLAIE
RIQQTMERLSDLLGKVQKALGEYLERQRSAFARFYFVGDEDLLEIIGNSKDIIKIQKHFR
KMFAGLANLTLDDEKTTIIGMSSAEGETVTFKKPISIANGPKIHEWLTMVESEMKSTLAT
LLSESLQHFNQVDVNDHSKYSEWVDNYPTQLVLLTSQIVWSTQVDQALGGGTLQQSKIQE
QLQSIEQTTQMILNNLADSVLQDLSAQKRKKFEHLITELVHQRDVVRQLQKCKNLTGNKD
FDWLYHMRYYYDATQENVLHKLVIHMANATFYYGFEYLGIGERLVQTPLTDRCYLTLTQA
LESRMGGNPFGPAGTGKTETVKALGSQLGRFVLVFCCDEGFDLQAMSRIFVGLCQCGAWG
CFDEFNRLEERILSAVSQQIQTIQVALKENSKEVELLGGKNISLHQDMGIFVTMNPGYAG
RSNLPDNLKKLFRSMAMIKPDREMIAQVMLYSQGFKTAEVLAGKIVPLFKLCQEQLSAQS
HYDFGLRALKSVLVSAGGIKRKCQPPQLPPITDAESKTKADQIYCQYEIGVLLNSINDTM
IPKLVADDIPLIQSLLLDVFPGSQLQPIQMDQLRKKIQEIAKQRHLVTKQEWVEKILQLH
QILNINHGVMMVGPSGGGKTTSWEVYLEAIEQVDNIKSEAHVMDPKAITKDQLFGSLDLT
TREWTDGLFTATLRRIIDNVRGESTKRHWIIFDGDVDPEWVENLNSLLDDNKLLTLPNGE
RLALPNNVRVMFEVQDLKYATLATISRCGMVWFSEEILTTQMIFQNYLDTLSNEPFDPQE
KEQQKRNENAQLQQQQQTTITSPILTSPPTTSSSSRSTTSTTSMIPAGLKVQKECAAIIS
QYFEPGGLVHKVLEDAGQRPHIMDFTRLRVLNSFFSLMNRSIVNVIEYNQLHSDFPMSPE
NQSNYITNRLLYSLMWGLGGSMGLVERENFSKFIQTIAITPVPANTIPLLDYSVSIDDAN
WSLWKNKVPSVEVETHKVASPDVVIPTVDTTRHVDVLHAWLSEHRPLILCGPPGSGKTMT
LTSTLRAFPDFEVVSLNFSSATTPELLLKTFDHHCEYKRTPSGETVLRPTQLGKWLVVFC
DEINLPSTDKYGTQRVITFIRQMVEKGGFWRTSDHTWIKLDKIQFVGACNPPTDAGRVQL
THRFLRHAPILLVDFPSTSSLTQIYGTFNRALMKLLPNLRSFADNLTDAMVEFYSESQKR
FTPDIQAHYIYSPRELSRWDRALLEAIQTMDGCTLEGLVRLWAHEALRLFQDRLVETEEK
EWTDKKIDEVALKHFPSVNLDALKRPILYSNWLTKDYQPVNRSDLREYVKARLKVFYEEE
LDVPLVLFNEVLDHILRIDRVFRQPQGHALLIGVSGGGKSVLSRFVAWMNGLSIYTIKVN
NNYKSSDFDDDLRMLLKRAGCKEEKICFIFDESNVLESSFLERMNTLLAGGEVPGLFEGE
EFTALMHACKETAQRNGLILDSEEELYKYFTSQVRRNLHVVFTMNPASPDFHNRSATSPA
LFNRCVLDWFGEWSPEALFQVGSEFTRNLDLENPQYIAPPVFIQEAEIMGNNLMAIPPSH
RDAVVSSLVYIHQTIGEANIRLLKRQGRQNYVTPRHYLDFINQVVLLINEKRDQLEEEQL
HLNIGLKKLRDTEAQVKDLQVSLAQKNRELDVKNEQANQKLKQMVQDQQAAEIKQKDARE
LQVQLDVRNKEIAVQKVKAYADLEKAEPAIIEAQEAVSTIKKKHLDEIKSLPKPPTPVKL
AMEAVCLMLGGKKLEWADIRKKIMEPNFITSIINYDTKKMMTPKIREAITKGYLEDPGFD
YETVNRASKACGPLVKWATAQTYYSEILDRIKPLREEVEQLENAANELKLKQDEIVATIT
ALEKSIATYKEEYATLIRETEQIKTESSKVKNKVDRSIALLDNLNSERGRWEQQSENFNT
QMSTVVGDVVLASAFLAYIGFFDQNFRTDLMRKWMIRLDSVGIKFKSDLSVPSFLSKPEE
RLNWHANSLPSDELCIENAIMLKRFNRYPLVIDPSGQAMEFLMNQYADKKITKTSFLDSS
FMKNLESALRFGCPLLVQDVENIDPVLNPVLNKEIRKKGGRILIRLGDQDVDFSPSFMIF
LFTRDPTAHFTPDLCSRVTFVNFTVTPSSLQSQCLHEALKTERPDTHKKRSDLLKIQGEF
QVKLRILEKSLLNALSQASGNILDDDSVISTLETLKKETTEIALKVEETETVMQEISEVS
ALYNPMALSCSRVYFAMEELSQFHLYQFSLRAFLDIFYNLLNNNPNLVDKKDPNERLVYL
SKDIFSMTFNRVTRTLLNDDKLTFALQLTIISVKGTSNEIEESEWDFLLKGGDNLTSIKE
TIPQLDSLLSTTQQKWLICLRQQVPSFSKLVDHIQQNSSDWKQFFGKDQVGEPIIPESWI
VAQAQLSNQQSTIVSNFRKILLMKAFHSDRVLQYSHSFVCSVFGEDFLNTQELDMANIVE
KEVKSSSPLLLCSVPGYDASSKVDDLALQLHKQYKSFAIGSPEGFELAEKSIYAAAKSGT
WVLLKNIHLAPQWLVQLEKKLHSLSPHPSFRLFMTSEIHPALPANLLRMSNVFSYENPPG
VKANLLHTFIGIPATRMDKQPAERSRIYFLLAWFHAIIQERLRYIPLGWTKFFEFNDADL
RGALDSIDYWVDLYSKGRSNIDPDKIPWIAVRTILGSTIYGGRIDNEFDMRLLYSFLEQL
FTPSAFNPDFPLVPSIGLSVPEGTTRAHFMKWIEALPEISTPIWLGLPENAESLLLSNKA
RKMINDLQKMQSSEEDGEDDQVSGSSKKESSSSSSEDKGKAKLRATITEWTKLLPKPLKQ
LKRTTQNIKDPLFRCFEREISTGGKLVKKITNDLANLLELISGNIKSTNYLRSLTTSISK
GIVPKEWKWYSVPETISLSVWISDFSKRMQQLSEISESSDYSSIQVWLGGLLNPEAYITA
TRQSASQLNGWSLENLRLHASSLGKISSEGGASFNVKGMALEGAVWNNDQLTPTDILSTP
ISIATLTWKDKDDPIFNNSSSKLSVPVYLNETRSELLFSIDLPYDQSTSKQNWYQRSVSI
SSWKSDI

Ligands and cofactors

IDNameFormulaCopies
AOVADP orthovanadateC10 H17 N5 O14 P2 V1
MGMagnesium ionMg2
ATPAdenosine-5'-triphosphateC10 H16 N5 O13 P31
ADPAdenosine-5'-diphosphateC10 H15 N5 O10 P22

Primary citation

ADP-Bound States of Cytoplasmic Dynein: Cryo-electron Microscopy Reveals a Two-Step Post-Power-Stroke Transition and Roles of Regulatory ATPase Sites. Imai, H., Kanazawa, R., Maeshima, T. et al. J Mol Biol (2026) 438:169977-169977. DOI 10.1016/j.jmb.2026.169977 · PubMed

Other PDB entries of the same protein (UniProt P34036), best resolution first:

Browse structure collections

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