28WY: Human SAC3D1-PCID2-SEM1 complex

Cryo-EM structure of the human SAC3D1-PCID2-SEM1 complex. Determined by electron microscopy at 3.6 Å resolution. Released 24 Jun 2026.

Method
Electron microscopy
Resolution
3.6 Å
Organisms
Escherichia coli, Homo sapiens
Chains
3
Atoms
4,929
Mol. weight
140.24 kDa
Released
24 Jun 2026

Explore 28WY in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

28WY contains 44 α-helices and 10 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 19 helices, 5 β-strands

ElementResiduesLengthSheet
α-helix63-719
α-helix77-793
β-strand8011
α-helix811
β-strand9111
α-helix93-953
α-helix112-1143
α-helix118-13316
α-helix141-15919
α-helix166-18520
α-helix197-21721
α-helix225-23511
α-helix240-2478
α-helix251-2555
α-helix257-27115
α-helix274-28310
α-helix286-31126
β-strand317-32042
α-helix321-3277
α-helix333-34311
β-strand34712
β-strand352-35542
α-helix374-3785
α-helix384-3874
Chain B: 22 helices, 4 β-strands
ElementResiduesLengthSheet
α-helix7-1812
α-helix22-298
α-helix48-536
α-helix56-7419
α-helix77-9721
α-helix104-12724
α-helix137-15418
α-helix155-1573
α-helix165-18117
α-helix185-19612
α-helix206-22217
α-helix226-23914
α-helix245-26218
β-strand265-26623
α-helix2671
α-helix268-2747
α-helix277-28812
α-helix291-30010
α-helix302-3076
α-helix311-33323
β-strand337-33934
α-helix340-34910
α-helix357-36913
β-strand375-37844
β-strand383-38644
α-helix395-3984
Chain C: 3 helices, 1 β-strand
ElementResiduesLengthSheet
α-helix19-235
α-helix34-363
β-strand39-4023
α-helix51-6313

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Maltose/maltodextrin-binding periplasmic protein,SAC3 domain-containing protein 1Aprotein736Escherichia coli, Homo sapiensA6NKF1 (AlphaFold model), P0AEX9 (AlphaFold model)
PCI domain-containing protein 2Bprotein457Homo sapiensQ5JVF3 (AlphaFold model)
26S proteasome complex subunit SEM1Cprotein70Homo sapiensP60896 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>28WY_1 Maltose/maltodextrin-binding periplasmic protein,SAC3 domain-containing protein 1 (chains A)
MKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDI
IFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNK
DLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIK
DVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSK
VNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPL
GAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDE
ALKDAQTSSGLEVLFQGPMPGCELPVGTCPDMCPAAERAQREREHRLHRLEVVPGCRQDP
PRADPQRAVKEYSRPAAGKPRPPPSQLRPPSVLLATVRYLAGEVAESADIARAEVASFVA
DRLRAVLLDLALQGAGDAEAAVVLEAALATLLTVVARLGPDAARGPADPVLLQAQVQEGF
GSLRRCYARGAGPHPRQPAFQGLFLLYNLGSVEALHEVLQLPAALRACPPLRKALAVDAA
FREGNAARLFRLLQTLPYLPSCAVQCHVGHARREALARFARAFSTPKGQTLPLGFMVNLL
ALDGLREARDLCQAHGLPLDGEERVVFLRGRYVEEGLPPASTCKVLVESKLRGRTLEEVV
MAEEEDEGTDRPGSPA
Sequence of entity 2 (B), FASTA
>28WY_2 PCI domain-containing protein 2 (chains B)
MGKPIPNPLLGLDSTGSGKPIPNPLLGLDSTGSGKPIPNPLLGLDSTSSGLEVLFQGPMA
HITINQYLQQVYEAIDSRDGASCAELVSFKHPHVANPRLQMASPEEKCQQVLEPPYDEMF
AAHLRCTYAVGNHDFIEAYKCQTVIVQSFLRAFQAHKEENWALPVMYAVALDLRVFANNA
DQQLVKKGKSKVGDMLEKAAELLMSCFRVCASDTRAGIEDSKKWGMLFLVNQLFKIYFKI
NKLHLCKPLIRAIDSSNLKDDYSTAQRVTYKYYVGRKAMFDSDFKQAEEYLSFAFEHCHR
SSQKNKRMILIYLLPVKMLLGHMPTVELLKKYHLMQFAEVTRAVSEGNLLLLHEALAKHE
AFFIRCGIFLILEKLKIITYRNLFKKVYLLLKTHQLSLDAFLVALKFMQVEDVDIDEVQC
ILANLIYMGHVKGYISHQHQKLVVSKQNPFPPLSTVC
Sequence of entity 3 (C), FASTA
>28WY_3 26S proteasome complex subunit SEM1 (chains C)
MSEKKQPVDLGLLEEDDEFEEFPAEDWAGLDEDEDAHVWEDNWDDDNVEDDFSNQLRAEL
EKHGYKMETS

Primary citation

Molecular basis of polyadenylated RNA fate determination in the nucleus. Bugai, A., Hohmann, U., Lorenzo, A. et al. Nature (2026) 655:1070-1078. DOI 10.1038/s41586-026-10650-0 · PubMed

Other PDB entries of the same protein (UniProt A6NKF1 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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