2A65: Na:neurotransmitter symporter

Crystal structure of LEUTAA, a bacterial homolog of Na+/Cl--dependent neurotransmitter transporters. Determined by X-ray diffraction at 1.65 Å resolution. Released 2 Aug 2005.

Method: X-ray diffraction
Resolution: 1.65 Å
Organism: Aquifex aeolicus
Chains: 1
Atoms: 4,366
Mol. weight: 59.75 kDa
Ligands: LEU, BOG
Released: 2 Aug 2005

Explore 2A65 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2A65 contains 36 α-helices and 4 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 36 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	11-22	12
α-helix	25	1
α-helix	26-30	5
α-helix	31-37	7
α-helix	41-50	10
α-helix	51-55	5
α-helix	56-70	15
α-helix	77-84	8
α-helix	88-94	7
α-helix	96-124	29
α-helix	137-152	16
β-strand	161	1	1
α-helix	166-183	18
α-helix	187-192	6
α-helix	193-213	21
β-strand	217-218	2	2
β-strand	221-222	2	2
α-helix	223-231	9
α-helix	241-255	15
α-helix	261-266	6
α-helix	276-287	12
α-helix	288-294	7
α-helix	295-306	12
α-helix	308-317	10
α-helix	321-326	6
α-helix	327-331	5
α-helix	337-369	33
α-helix	375-395	21
β-strand	396	1	1
α-helix	399-405	7
α-helix	406-411	6
α-helix	412-420	9
α-helix	421-426	6
α-helix	429-437	9
α-helix	443-445	3
α-helix	447-450	4
α-helix	451-455	5
α-helix	456-470	15
α-helix	472-477	6
α-helix	483-513	31

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Na(+):neurotransmitter symporter (Snf family)	A	protein	519	Aquifex aeolicus	O67854 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2A65_1 Na(+):neurotransmitter symporter (Snf family) (chains A)
MEVKREHWATRLGLILAMAGNAVGLGNFLRFPVQAAENGGGAFMIPYIIAFLLVGIPLMW
IEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVVAIYYVYIESWTLGFAI
KFLVGLVPEPPPNATDPDSILRPFKEFLYSYIGVPKGDEPILKPSLFAYIVFLITMFINV
SILIRGISKGIERFAKIAMPTLFILAVFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKD
PGVWIAAVGQIFFTLSLGFGAIITYASYVRKDQDIVLSGLTAATLNEKAEVILGGSISIP
AAVAFFGVANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSSIAIM
QPMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFWAGTIGVVFFGLTEL
IIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYITPAFLAVLLVVWAREYIPKIMEETH
WTVWITRFYIIGLFLFLTFLVFLAERRRNHESAGTLVPR

Ligands and cofactors

ID	Name	Formula	Copies
LEU	Leucine	C6 H13 N O2	1
BOG	octyl beta-D-glucopyranoside	C14 H28 O6	5

Water and common crystallization additives (NA, CL) are not listed.

Primary citation

Crystal structure of a bacterial homologue of Na(+)/Cl(-)-dependent neurotransmitter transporters. Yamashita, A., Singh, S.K., Kawate, T. et al. Nature (2005) 437:215-223. DOI 10.1038/nature03978 · PubMed

Other PDB entries of the same protein (UniProt O67854 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2Q72 1.7 Å, Crystal Structure Analysis of LeuT complexed with L-leucine, sodium, and imipramine
3F3E 1.8 Å, Crystal structure of LeuT bound to L-leucine (30 mM) and sodium
2Q6H 1.85 Å, Crystal Structure Analysis of LeuT complexed with L-leucine, sodium, and clomipramine
2QEI 1.85 Å, Crystal structure analysis of LeuT complexed with L-alanine, sodium, and clomipramine
2QB4 1.9 Å, Crystal Structure Analysis of LeuT complexed with L-leucine, sodium and desipramine
3F48 1.9 Å, Crystal structure of LeuT bound to L-alanine and sodium
3F4I 1.95 Å, Crystal Structure of LeuT bound to L-selenomethionine and sodium
3F3A 2.0 Å, Crystal Structure of LeuT bound to L-Tryptophan and Sodium
3GJD 2.0 Å, Crystal Structure of LeuT with bound OG
3F3C 2.1 Å, Crystal structure of LeuT bound to 4-Fluoro-L-Phenylalanine and sodium
3USP 2.1 Å, Crystal structure of LeuT in heptyl-beta-D-Selenoglucoside
7LQK 2.1 Å, Crystal structure of the R375A mutant of LeuT

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