2AEQ: Neuraminidase

An epidemiologically significant epitope of a 1998 influenza virus neuraminidase forms a highly hydrated interface in the NA-antibody complex. Determined by X-ray diffraction at 3.0 Å resolution. Released 20 Dec 2005.

Method: X-ray diffraction
Resolution: 3.0 Å
Organisms: Influenza A virus, Mus musculus
Chains: 3
Atoms: 4,900
Mol. weight: 93.21 kDa
Ligands: NAG, MAN
Released: 20 Dec 2005

Explore 2AEQ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2AEQ contains 6 α-helices and 51 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 4 helices, 30 β-strands

Element	Residues	Length	Sheet
β-strand	91	1	1
β-strand	96-102	7	1
α-helix	105-109	5
β-strand	114	1	2
β-strand	115	1	3
β-strand	121-124	4	4
β-strand	129-134	6	4
β-strand	139	1	3
α-helix	143-145	3
β-strand	157-162	6	4
β-strand	168	1	2
β-strand	172-176	5	4
β-strand	179-184	6	5
β-strand	189-197	9	5
β-strand	200-207	8	5
β-strand	210-216	7	5
β-strand	224-225	2	6
β-strand	231-233	3	6
β-strand	236-244	9	6
β-strand	250-258	9	6
β-strand	261-267	7	6
β-strand	276-283	8	7
β-strand	286-292	7	7
α-helix	300	1
β-strand	301-305	5	7
β-strand	312-316	5	7
β-strand	353-356	4	8
β-strand	359-364	6	8
β-strand	372-380	9	8
β-strand	390-403	14	8
β-strand	407-413	7	1
β-strand	418-429	12	1
β-strand	439-449	11	1
α-helix	464-466	3

Chain H: 0 helices, 10 β-strands

Element	Residues	Length	Sheet
β-strand	5-7	3	11
β-strand	18-23	6	11
β-strand	33-39	7	12
β-strand	46-51	6	12
β-strand	60-62	3	12
β-strand	71-75	5	11
β-strand	80-85	6	11
β-strand	95-101	7	12
β-strand	110	1	12
β-strand	114-115	2	12

Chain L: 2 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	4-5	2	9
β-strand	10-13	4	10
β-strand	18-25	8	9
β-strand	33-38	6	10
β-strand	45-48	4	10
β-strand	54	1	10
β-strand	62-67	6	9
β-strand	70-76	7	9
α-helix	80-82	3
β-strand	85-90	6	10
α-helix	96	1
β-strand	97-98	2	10
β-strand	102-106	5	10

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
neuraminidase	A	protein	395	Influenza A virus	Q80DL0
FAB light chain	L	protein	214	Mus musculus
FAB heavy chain	H	protein	217	Mus musculus	P84751 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2AEQ_1 neuraminidase (chains A)
KEICPKLAEYRNWSKPQCKITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPDKCYQFAL
GQGTTLNNRHSNDTVHDRTPYRTLLMNELGVPFHLGTKQVCIAWSSSSCHDGKAWLHVCV
TGHDENATASFIYDGRLVDSIGSWSKKILRTQESECVCINGTCTVVMTDGSASGRADTKI
LFIEEGKIVHISPLSGSAQHVEECSCYPRYPGVRCVCRDNWKGSNRPIVDINVKDYSIVS
SYVCSGLVGDTPRKNDSSSSSHCLNPNNEEGGHGVKGWAFDDGNDVWMGRTISEKFRSGY
ETFKVIEGWSKPNSKLQINRQVIVDRGNRSGYSGIFSVEGKSCINRCFYVELIRGRKQET
EVWWTSNSIVVFCGTSGTYGTGSWPDGADINLMPI

Sequence of entity 2 (L), FASTA

>2AEQ_2 FAB light chain (chains L)
DILMTQSQKFLSTSVGDRVSVTCKASQNVGTNVAWYQQKPGQSPKPLMYSASYRYSGVPD
RFTGSGSGTDFTLTISNVQSEDLAEYFCQQFNRYPLTFGSGTKLELKRADAAPTVSIFPP
SSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLT
LTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC

Sequence of entity 3 (H), FASTA

>2AEQ_3 FAB heavy chain (chains H)
EVKLVESGGGLVQPGGSLSLSCATSGFTFIDYYMSWFRQPPGKALEWLGLIRNKGNGYTM
EYSASLKGRFTISRDNSQSIVYLHMNTLTAEDSATYYCARVDYGTNYDYWGQGTTLTVSS
AKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSD
LYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKI

Ligands and cofactors

ID	Name	Formula	Copies
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose	C8 H15 N O6	7
MAN	alpha-D-mannopyranose	C6 H12 O6	4

Primary citation

An Epidemiologically Significant Epitope of a 1998 Human Influenza Virus Neuraminidase Forms a Highly Hydrated Interface in the NA-Antibody Complex. Venkatramani, L., Bochkareva, E., Lee, J.T. et al. J Mol Biol (2006) 356:651-663. DOI 10.1016/j.jmb.2005.11.061 · PubMed

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