2FHW: Human relaxin-3

Solution structure of human relaxin-3. Determined by solution NMR. Released 24 Jan 2006.

Method: Solution NMR
Chains: 2
Atoms: 382
Mol. weight: 5.51 kDa
Released: 24 Jan 2006

Explore 2FHW in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2FHW contains 3 α-helices and 2 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 1 β-strand

Element	Residues	Length	Sheet
α-helix	2-12	11
β-strand	15-16	2	1
α-helix	17-21	5

Chain B: 1 helix, 1 β-strand

Element	Residues	Length	Sheet
β-strand	6-7	2	1
α-helix	12-22	11

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Relaxin 3 (Prorelaxin H3) (Insulin-like peptide INSL7) (Insulin-like peptide 7)	B	protein	27		Q8WXF3 (AlphaFold model)
Relaxin 3 (Prorelaxin H3) (Insulin-like peptide INSL7) (Insulin-like peptide 7)	A	protein	24		Q8WXF3 (AlphaFold model)

Sequence of entity 1 (B), FASTA

>2FHW_1 Relaxin 3 (Prorelaxin H3) (Insulin-like peptide INSL7) (Insulin-like peptide 7) (chains B)
RAAPYGVRLCGREFIRAVIFTCGGSRW

Sequence of entity 2 (A), FASTA

>2FHW_2 Relaxin 3 (Prorelaxin H3) (Insulin-like peptide INSL7) (Insulin-like peptide 7) (chains A)
DVLAGLSSSCCKWGCSKSEISSLC

Primary citation

Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3. Rosengren, K.J., Lin, F., Bathgate, R.A. et al. J Biol Chem (2006) 281:5845-5851. DOI 10.1074/jbc.M511210200 · PubMed

Other PDB entries of the same protein (UniProt Q8WXF3 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9KFI 2.91 Å, Cryo-EM structure of the human relaxin family peptide receptor 3 in complex with…
9KFK 2.95 Å, Cryo-EM structure of the relaxin-3-bound human relaxin family peptide receptor 4…
2K1V R3/I5 relaxin chimera

Browse structure collections

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