2HEW: Murine OX40L

The X-ray crystal structure of murine OX40L. Determined by X-ray diffraction at 1.45 Å resolution. Released 29 Aug 2006.

Method
X-ray diffraction
Resolution
1.45 Å
Organism
Mus musculus
Chains
1
Atoms
1,159
Mol. weight
17.38 kDa
Ligands
NAG
Released
29 Aug 2006

Explore 2HEW in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2HEW contains 4 α-helices and 13 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain F: 4 helices, 13 β-strands

ElementResiduesLengthSheet
α-helix59-613
β-strand62-71101
β-strand74-7851
β-strand88-9032
β-strand93-9532
β-strand9813
β-strand100-110111
β-strand116-11941
α-helix125-1262
β-strand127-12931
α-helix130-1323
β-strand137-146101
β-strand151-15222
β-strand153-15641
α-helix160-1656
β-strand168-177101
β-strand18313

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Tumor necrosis factor ligand superfamily member 4Fprotein152Mus musculusP43488 (AlphaFold model)
Sequence of entity 1 (F), FASTA
>2HEW_1 Tumor necrosis factor ligand superfamily member 4 (chains F)
GSHMSSSPAKDPPIQRLRGAVTRCEDGQLFISSYKNEYQTMEVQNNSVVIKCDGLYIIYL
KGSFFQEVKIDLHFREDHNPISIPMLNDGRRIVFTVVASLAFKDKVYLTVNAPDTLCEHL
QINDGELIVVQLTPGYCAPEGSYHSTVNQVPL

Ligands and cofactors

IDNameFormulaCopies
NAG2-acetamido-2-deoxy-beta-D-glucopyranoseC8 H15 N O61

Water and common crystallization additives (SO4) are not listed.

Primary citation

The Crystal Structure of the Costimulatory OX40-OX40L Complex. Compaan, D.M., Hymowitz, S.G. Structure (2006) 14:1321-1330. DOI 10.1016/j.str.2006.06.015 · PubMed

Other PDB entries of the same protein (UniProt P43488 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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