2ID5: Lingo-1 Ectodomain

Crystal Structure of the Lingo-1 Ectodomain. Determined by X-ray diffraction at 2.7 Å resolution. Released 26 Sept 2006.

Method: X-ray diffraction
Resolution: 2.7 Å
Organism: Homo sapiens
Chains: 4
Atoms: 16,119
Mol. weight: 227.59 kDa
Ligands: NAG
Released: 26 Sept 2006

Explore 2ID5 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2ID5 contains 52 α-helices and 153 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 13 helices, 39 β-strands

Element	Residues	Length	Sheet
β-strand	8-10	3	1
β-strand	15-17	3	1
α-helix	26-27	2
β-strand	36-38	3	1
β-strand	46-47	2	2
β-strand	60-62	3	1
β-strand	70-71	2	2
β-strand	84-86	3	1
α-helix	95-96	2
β-strand	108-110	3	1
β-strand	118-119	2	3
β-strand	132-135	4	1
β-strand	142-143	2	3
β-strand	156-160	5	1
α-helix	169-172	4
β-strand	180-184	5	1
β-strand	190-191	2	4
β-strand	204-208	5	1
β-strand	215-216	2	4
β-strand	228-232	5	1
α-helix	241-244	4
β-strand	252-254	3	1
β-strand	262-263	2	5
β-strand	276-278	3	1
β-strand	286-287	2	5
β-strand	292	1	6
β-strand	300-302	3	1
α-helix	313-315	3
β-strand	316	1	6
α-helix	319-321	3
β-strand	324-326	3	1
β-strand	332-333	2	7
α-helix	336-338	3
α-helix	339-342	4
β-strand	356	1	8
β-strand	357-359	3	7
α-helix	361-363	3
β-strand	367	1	8
α-helix	368-370	3
α-helix	375-376	2
β-strand	383-387	5	9
α-helix	392	1
β-strand	393-398	6	10
β-strand	403-405	3	11
β-strand	409-412	4	9
α-helix	414-415	2
β-strand	416-420	5	10
β-strand	426	1	10
β-strand	436-437	2	11
β-strand	443-445	3	11
β-strand	454-462	9	10
β-strand	465-476	12	10

Chain B: 13 helices, 39 β-strands

Element	Residues	Length	Sheet
β-strand	8-10	3	12
α-helix	11-13	3
β-strand	15-17	3	12
α-helix	26-27	2
β-strand	36-38	3	12
β-strand	46-47	2	13
β-strand	60-62	3	12
β-strand	70-71	2	13
β-strand	84-86	3	12
β-strand	108-110	3	12
β-strand	118-119	2	14
β-strand	132-135	4	12
β-strand	142-143	2	14
β-strand	156-160	5	12
α-helix	169-172	4
β-strand	180-184	5	12
β-strand	190-191	2	15
β-strand	204-208	5	12
β-strand	215-216	2	15
β-strand	228-232	5	12
β-strand	252-254	3	12
β-strand	262-263	2	16
β-strand	276-278	3	12
β-strand	286-287	2	16
β-strand	292	1	17
β-strand	300-302	3	12
α-helix	313-315	3
β-strand	316	1	17
α-helix	319-321	3
β-strand	324-326	3	12
β-strand	332-333	2	18
α-helix	336-338	3
α-helix	339-342	4
β-strand	356	1	19
β-strand	357-359	3	18
α-helix	361-363	3
β-strand	367	1	19
α-helix	368-370	3
α-helix	375-376	2
β-strand	383-387	5	20
α-helix	392	1
β-strand	393-396	4	21
β-strand	403-405	3	22
β-strand	409-412	4	20
α-helix	414-415	2
β-strand	416-420	5	21
β-strand	426-427	2	21
β-strand	435-437	3	22
β-strand	443-445	3	22
α-helix	450-452	3
β-strand	454-462	9	21
β-strand	465-474	10	21

Chain C: 16 helices, 38 β-strands

Element	Residues	Length	Sheet
β-strand	8-10	3	23
β-strand	15-17	3	23
α-helix	26-27	2
β-strand	36-38	3	23
β-strand	46-47	2	24
α-helix	48	1
β-strand	60-62	3	23
β-strand	70-71	2	24
β-strand	84-86	3	23
α-helix	95-96	2
β-strand	108-110	3	23
β-strand	118-119	2	25
α-helix	120	1
β-strand	132-135	4	23
β-strand	142-143	2	25
β-strand	156-160	5	23
α-helix	169-172	4
β-strand	180-184	5	23
β-strand	190-191	2	26
β-strand	204-208	5	23
β-strand	215-216	2	26
β-strand	228-232	5	23
α-helix	241-244	4
β-strand	252-254	3	23
β-strand	262-263	2	27
β-strand	276-278	3	23
β-strand	286-287	2	27
β-strand	292	1	28
β-strand	300-302	3	23
α-helix	313-315	3
β-strand	316	1	28
α-helix	319-321	3
β-strand	324-326	3	23
β-strand	332-333	2	29
α-helix	336-338	3
α-helix	339-342	4
β-strand	356	1	30
β-strand	357-359	3	29
α-helix	361-363	3
β-strand	367	1	30
α-helix	368-370	3
α-helix	375-376	2
β-strand	383-387	5	31
α-helix	392	1
β-strand	393-398	6	32
β-strand	403-405	3	33
β-strand	409-412	4	31
α-helix	414-415	2
β-strand	416-420	5	32
β-strand	435-437	3	33
β-strand	443-445	3	33
α-helix	450-452	3
β-strand	454-462	9	32
β-strand	465-476	12	32

Chain D: 10 helices, 37 β-strands

Element	Residues	Length	Sheet
β-strand	8-10	3	34
β-strand	15-17	3	34
β-strand	37-38	2	35
β-strand	46-47	2	36
β-strand	61-62	2	35
β-strand	70-71	2	36
β-strand	84-86	3	35
β-strand	108-110	3	35
β-strand	118-119	2	37
β-strand	132-135	4	35
β-strand	142-143	2	37
β-strand	156-160	5	35
α-helix	169-172	4
β-strand	180-184	5	35
β-strand	190-191	2	38
β-strand	204-208	5	35
β-strand	215-216	2	38
β-strand	228-232	5	35
β-strand	252-254	3	35
β-strand	262-263	2	39
β-strand	276-278	3	35
β-strand	286-287	2	39
β-strand	300-302	3	35
α-helix	313-315	3
α-helix	319-321	3
β-strand	324-326	3	35
β-strand	332-333	2	40
α-helix	336-338	3
α-helix	339-342	4
β-strand	356	1	41
β-strand	357-359	3	40
α-helix	361-363	3
β-strand	367	1	41
α-helix	368-370	3
α-helix	375-376	2
β-strand	383-387	5	42
α-helix	392	1
β-strand	393-397	5	43
β-strand	403-405	3	44
β-strand	409-412	4	42
β-strand	416-420	5	43
β-strand	426-427	2	43
β-strand	435-437	3	44
β-strand	443-445	3	44
α-helix	450-452	3
β-strand	454-462	9	43
β-strand	465-475	11	43

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Leucine rich repeat neuronal 6A	A, B, C, D	protein	477	Homo sapiens	Q96FE5 (AlphaFold model)

Sequence of entity 1 (A, B, C, D), FASTA

>2ID5_1 Leucine rich repeat neuronal 6A (chains A, B, C, D)
TGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEE
LELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILL
DYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIV
LRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVP
YLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRV
LNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATP
EFVQGKEFKDFPDVLLPNYFTCRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWL
SPRKHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRS

Ligands and cofactors

ID	Name	Formula	Copies
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose	C8 H15 N O6	13

Primary citation

The structure of the Lingo-1 ectodomain, a module implicated in central nervous system repair inhibition. Mosyak, L., Wood, A., Dwyer, B. et al. J Biol Chem (2006) 281:36378-36390. DOI 10.1074/jbc.M607314200 · PubMed

Other PDB entries of the same protein (UniProt Q96FE5 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4OQT 3.23 Å, LINGO-1/Li81 Fab complex

Browse structure collections

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