Structure of a Plasmodium falciparum apical membrane antigen 1-Fab F8. 12.19 complex. Determined by X-ray diffraction at 2.9 Å resolution. Released 30 Jan 2007.
Explore 2J5L in 3D Show helices and sheets RCSB PDB PDBe
2J5L contains 13 α-helices and 47 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 481-482 | 2 | 1 |
| α-helix | 486-488 | 3 | |
| α-helix | 494 | 1 | |
| β-strand | 495-496 | 2 | 1 |
| β-strand | 505-506 | 2 | 1 |
| β-strand | 510 | 1 | 2 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 4-7 | 4 | 3 |
| β-strand | 10-13 | 4 | 4 |
| β-strand | 19-25 | 7 | 3 |
| β-strand | 34-38 | 5 | 4 |
| β-strand | 45-49 | 5 | 4 |
| β-strand | 53-54 | 2 | 4 |
| α-helix | 55 | 1 | |
| β-strand | 62-67 | 6 | 3 |
| β-strand | 70-75 | 6 | 3 |
| α-helix | 80-82 | 3 | |
| β-strand | 84-90 | 7 | 4 |
| β-strand | 93 | 1 | 2 |
| β-strand | 97-98 | 2 | 4 |
| β-strand | 102-106 | 5 | 4 |
| β-strand | 111 | 1 | 5 |
| β-strand | 114-118 | 5 | 6 |
| α-helix | 122-126 | 5 | |
| β-strand | 129-139 | 11 | 6 |
| β-strand | 140 | 1 | 5 |
| β-strand | 146-150 | 5 | 7 |
| β-strand | 154-155 | 2 | 7 |
| β-strand | 159-163 | 5 | 6 |
| β-strand | 173-182 | 10 | 6 |
| α-helix | 183-187 | 5 | |
| β-strand | 191-196 | 6 | 7 |
| β-strand | 205-210 | 6 | 7 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 3-7 | 5 | 8 |
| β-strand | 10-12 | 3 | 9 |
| β-strand | 18-25 | 8 | 8 |
| α-helix | 29-31 | 3 | |
| β-strand | 34-39 | 6 | 9 |
| β-strand | 45-51 | 7 | 9 |
| β-strand | 57-59 | 3 | 9 |
| α-helix | 61-63 | 3 | |
| β-strand | 64 | 1 | 8 |
| β-strand | 67-71 | 5 | 8 |
| β-strand | 77-82 | 6 | 8 |
| α-helix | 84-86 | 3 | |
| β-strand | 88-94 | 7 | 9 |
| α-helix | 98-100 | 3 | |
| β-strand | 102-103 | 2 | 9 |
| β-strand | 107-111 | 5 | 9 |
| β-strand | 120-124 | 5 | 10 |
| β-strand | 137-145 | 9 | 10 |
| β-strand | 153-157 | 4 | 11 |
| α-helix | 162-164 | 3 | |
| β-strand | 166 | 1 | 11 |
| β-strand | 171-173 | 3 | 10 |
| α-helix | 174-176 | 3 | |
| β-strand | 177-178 | 2 | 10 |
| β-strand | 185-194 | 10 | 10 |
| β-strand | 206-212 | 6 | 11 |
| α-helix | 213-215 | 3 | |
| β-strand | 217-222 | 6 | 11 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Apical membrane antigen 1 | A | protein | 581 | PLASMODIUM FALCIPARUM | Q9BIM8 (AlphaFold model) |
| FAB fragment of monoclonal antibody F8.12.19 | B | protein | 213 | MUS MUSCULUS | Q5XFY8 (AlphaFold model) |
| FAB fragment of monoclonal antibody F8.12.19 | C | protein | 225 | MUS MUSCULUS |
>2J5L_1 APICAL MEMBRANE ANTIGEN 1 (chains A) QKSDVYHPINEHREHPKEYEYPLHQEHTYQQEDSGEDENTLQHAYPIDHEGAEPAPQEQN LFSSIEIVERSNYMGNPWTEYMAKYDIEEVHGSGIRVDLGEDAEVAGTQYRLPSGKCPVF GKGIIIENSNTTFLKPVATGNQDLKDGGFAFPPTNPLISPMTLNGMRDFYKNNEYVKNLD ELTLCSRHAGNMNPDNDKNSNYKYPAVYDYNDKKCHILYIAAQENNGPRYCNKDQSKRNS MFCFRPAKDKLFENYTYLSKNVVDNWEEVCPRKNLENAKFGLWVDGNCEDIPHVNEFSAN DLFECNKLVFELSASDQPKQYEQHLTDYEKIKEGFKNKNASMIKSAFLPTGAFKADRYKS HGKGYNWGNYNRETQKCEIFNVKPTCLINNSSYIATTALSHPIEVEHNFPCSLYKDEIKK EIERESKRIKLNDNDDEGNKKIIAPRIFISDDKDSLKCPCDPEMVSQSTCRFFVCKCVER RAEVTSNNEVVVKEEYKDEYADIPEHKPTYDNMKIIIASSAAVAVLATILMVYLYKRKGN AEKYDKMDQPQHYGKSTSRNDEMLDPEASFWGEEKRASHTT
>2J5L_2 FAB FRAGMENT OF MONOCLONAL ANTIBODY F8.12.19 (chains B) QSVLSQSPAILSASPGEKVTMTCRARSSVSYMHWYQQKSGSSPKPWIHATSNLASGVPAR FSGSGSGTSYSLTISRVEAEDAATYYCQQWSSHPPTFGSGTKLEIKRADAAPTVSIFPPS SEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTL TKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC
>2J5L_3 FAB FRAGMENT OF MONOCLONAL ANTIBODY F8.12.19 (chains C) EVQLVESGGGLVKPGGSLKLSCAASGFIFSDYYMYWVRQTPEKRLEWVATISDGNSYTYY VDSVKGRFTISRDNAKNNLYLQMSSLKSEDTAIYYCARDGPTDSSGYGGFGYWGQGTLVT VSEAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVL QSDLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKIVPRDC
Cross-Reactivity Studies of an Anti-Plasmodium Vivax Apical Membrane Antigen 1 Monoclonal Antibody: Binding and Structural Characterisation. Igonet, S., Vulliez-Le Normand, B., Faure, G. et al. J Mol Biol (2007) 366:1523. DOI 10.1016/J.JMB.2006.12.028 · PubMed
Other PDB entries of the same protein (UniProt Q9BIM8 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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