2KBC: Human insulin-like peptide 5

Solution structure of human insulin-like peptide 5 (INSL5). Determined by solution NMR. Released 24 Mar 2009.

Method: Solution NMR
Organism: synthetic construct
Chains: 2
Atoms: 347
Mol. weight: 5.05 kDa
Released: 24 Mar 2009

Explore 2KBC in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2KBC contains 3 α-helices and 2 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 1 β-strand

Element	Residues	Length	Sheet
α-helix	6-8	3
β-strand	12	1	1
α-helix	14-20	7

Chain B: 1 helix, 1 β-strand

Element	Residues	Length	Sheet
β-strand	4	1	1
α-helix	9-23	15

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
INSL5_B-chain	B	protein	25	synthetic construct	Q9Y5Q6 (AlphaFold model)
INSL5_A-chain	A	protein	22	synthetic construct	Q9Y5Q6 (AlphaFold model)

Sequence of entity 1 (B), FASTA

>2KBC_1 INSL5_B-chain (chains B)
KESVRLCGLEYIRTVIYICASSRWX

Sequence of entity 2 (A), FASTA

>2KBC_2 INSL5_A-chain (chains A)
QDLQTLCCTDGCSMTDLSALCX

Primary citation

Structure of human insulin-like peptide 5 and characterization of conserved hydrogen bonds and electrostatic interactions within the relaxin framework. Hossain, M.A., Daly, N.L., Craik, D.J. et al. Biochem J (2009) 419:619-627. DOI 10.1042/BJ20082353 · PubMed

Other PDB entries of the same protein (UniProt Q9Y5Q6 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7YJ4 3.19 Å, Cryo-EM structure of the INSL5-bound human relaxin family peptidereceptor 4 (RXFP4)-Gi…
2K1V R3/I5 relaxin chimera

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