2L2L: Coiled-coil complex between MBD2 and p66alpha

Solution structure of the coiled-coil complex between MBD2 and p66alpha. Determined by solution NMR. Released 4 May 2011.

Method
Solution NMR
Organism
Homo sapiens
Chains
2
Atoms
649
Mol. weight
9.3 kDa
Released
4 May 2011

Explore 2L2L in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2L2L contains 2 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 1 helix, 0 β-strands

ElementResiduesLengthSheet
α-helix138-16831
Chain B: 1 helix, 0 β-strands
ElementResiduesLengthSheet
α-helix217-23923

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Transcriptional repressor p66-alphaAprotein43Homo sapiensQ86YP4 (AlphaFold model)
Methyl-CpG-binding domain protein 2Bprotein36Homo sapiensQ9UBB5 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>2L2L_1 Transcriptional repressor p66-alpha (chains A)
GSPEERERMIKQLKEELRLEEAKLVLLKKLRQSQIQKEATAQK
Sequence of entity 2 (B), FASTA
>2L2L_2 Methyl-CpG-binding domain protein 2 (chains B)
GSKAFIVTDEDIRKQEERVQQVRKKLEEALMADILS

Primary citation

p66Alpha-MBD2 coiled-coil interaction and recruitment of Mi-2 are critical for globin gene silencing by the MBD2-NuRD complex. Gnanapragasam, M.N., Scarsdale, J.N., Amaya, M.L. et al. Proc Natl Acad Sci U S A (2011) 108:7487-7492. DOI 10.1073/pnas.1015341108 · PubMed

Other PDB entries of the same protein (UniProt Q86YP4 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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