Solution NMR Structure of apo-calmodulin in complex with the IQ motif of Human Cardiac Sodium Channel NaV1.5. Determined by solution NMR. Released 5 Jan 2011.
Explore 2L53 in 3D Show helices and sheets RCSB PDB PDBe
2L53 contains 10 α-helices and 5 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 6-19 | 14 | |
| β-strand | 26-28 | 3 | 1 |
| α-helix | 29-38 | 10 | |
| α-helix | 45-53 | 9 | |
| α-helix | 56-58 | 3 | |
| β-strand | 62-64 | 3 | 1 |
| α-helix | 65-75 | 11 | |
| α-helix | 82-92 | 11 | |
| β-strand | 100-101 | 2 | 2 |
| α-helix | 102-110 | 9 | |
| α-helix | 118-129 | 12 | |
| β-strand | 132 | 1 | 2 |
| β-strand | 135-136 | 2 | 2 |
| α-helix | 138-144 | 7 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | -1-1920 | 21 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Calmodulin | A | protein | 148 | Homo sapiens | P62158 |
| Voltage-gated sodium channel type V alpha isoform b variant | B | protein | 31 | Homo sapiens | Q14524 (AlphaFold model) |
>2L53_1 Calmodulin (chains A) ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGN GTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEE VDEMIREADIDGDGQVNYEEFVQMMTAK
>2L53_2 Voltage-gated sodium channel type V alpha isoform b variant (chains B) GPGSEEVSAMVIQRAFRRHLLQRSLKHASFL
Solution NMR Structure of Apo-Calmodulin in Complex with the IQ Motif of Human Cardiac Sodium Channel NaV1.5. Chagot, B., Chazin, W.J. J Mol Biol (2011) 406:106-119. DOI 10.1016/j.jmb.2010.11.046 · PubMed
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