Crystal structure of human factor XA complexed with 3-chloro-N-(4-chloro-2-{[(5-chloropyridin-2-yl)amino]carbonyl}-6-methoxyphenyl)-4-[(1-methyl-1H-imidazol-2-yl)methyl]thiophene-2-carboxamide {Pfizer 320663}. Determined by X-ray diffraction at 1.62 Å resolution. Released 11 Sept 2007.
Explore 2P3U in 3D Show helices and sheets RCSB PDB PDBe
2P3U contains 12 α-helices and 26 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 88-90 | 3 | |
| α-helix | 92-95 | 4 | |
| β-strand | 99-103 | 5 | 1 |
| β-strand | 106-110 | 5 | 1 |
| β-strand | 115-117 | 3 | 2 |
| β-strand | 124-126 | 3 | 2 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 17 | 1 | 3 |
| β-strand | 20-21 | 2 | 4 |
| β-strand | 30-34 | 5 | 5 |
| β-strand | 40-46 | 7 | 5 |
| β-strand | 51-54 | 4 | 5 |
| α-helix | 56-60 | 5 | |
| β-strand | 65-68 | 4 | 5 |
| β-strand | 72 | 1 | 6 |
| β-strand | 81-90 | 10 | 5 |
| β-strand | 104-108 | 5 | 5 |
| β-strand | 115 | 1 | 7 |
| β-strand | 118 | 1 | 7 |
| α-helix | 120-121 | 2 | |
| β-strand | 122 | 1 | 4 |
| α-helix | 123-124A | 3 | |
| α-helix | 125-127 | 3 | |
| α-helix | 128-131A | 5 | |
| β-strand | 135-140 | 6 | 4 |
| β-strand | 143 | 1 | 8 |
| α-helix | 150 | 1 | |
| β-strand | 151 | 1 | 8 |
| α-helix | 152 | 1 | |
| β-strand | 154 | 1 | 6 |
| β-strand | 156-162 | 7 | 4 |
| α-helix | 165-171 | 7 | |
| β-strand | 180-183 | 4 | 4 |
| β-strand | 189 | 1 | 3 |
| β-strand | 198-203 | 6 | 4 |
| β-strand | 206-215 | 10 | 4 |
| β-strand | 226-230 | 5 | 4 |
| α-helix | 231-234 | 4 | |
| α-helix | 235-241 | 7 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Coagulation factor X | A | protein | 52 | Homo sapiens | P00742 (AlphaFold model) |
| Coagulation factor X | B | protein | 233 | Homo sapiens | P00742 (AlphaFold model) |
>2P3U_1 Coagulation factor X (chains A) KLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLE
>2P3U_2 Coagulation factor X (chains B) IVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTE QEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLM TQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDA CQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMK
| ID | Name | Formula | Copies |
|---|---|---|---|
| 663 | 3-chloro-N-(4-chloro-2-{[(5-chloropyridin-2-yl)amino]carbonyl}-6-methoxyphenyl)… | C23 H18 Cl3 N5 O3 S | 1 |
| CA | Calcium ion | Ca | 2 |
Crystal structure of human factor XA complexed with 3-chloro-N-(4-chloro-2-{[(5-chloropyridin-2-yl)amino]carbonyl}-6-methoxyphenyl)-4-[(1-methyl-1H-imidazol-2-yl)methyl]thiophene-2-carboxamide {Pfizer 320663}. Adler, M. Not Published.
Other PDB entries of the same protein (UniProt P00742 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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