Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor. Determined by X-ray diffraction at 1.28 Å resolution. Released 22 Jan 2008.
Explore 2R3I in 3D Show helices and sheets RCSB PDB PDBe
2R3I contains 18 α-helices and 11 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 4-12 | 9 | 1 |
| β-strand | 17-23 | 7 | 1 |
| β-strand | 29-34 | 6 | 1 |
| α-helix | 46-55 | 10 | |
| β-strand | 63 | 1 | 2 |
| β-strand | 66-72 | 7 | 1 |
| β-strand | 75-81 | 7 | 1 |
| β-strand | 85-86 | 2 | 2 |
| α-helix | 87-93 | 7 | |
| α-helix | 101-120 | 20 | |
| α-helix | 130-132 | 3 | |
| β-strand | 133-135 | 3 | 2 |
| β-strand | 141-143 | 3 | 2 |
| α-helix | 148-152 | 5 | |
| β-strand | 157 | 1 | 3 |
| α-helix | 162 | 1 | |
| β-strand | 163 | 1 | 3 |
| α-helix | 164-165 | 2 | |
| α-helix | 171-174 | 4 | |
| α-helix | 183-198 | 16 | |
| α-helix | 208-219 | 12 | |
| α-helix | 230-232 | 3 | |
| α-helix | 243-247 | 5 | |
| α-helix | 248-251 | 4 | |
| α-helix | 257-266 | 10 | |
| α-helix | 275-276 | 2 | |
| α-helix | 277-281 | 5 | |
| α-helix | 284-286 | 3 | |
| α-helix | 292-294 | 3 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Cell division protein kinase 2 | A | protein | 299 | Homo sapiens | P24941 (AlphaFold model) |
>2R3I_1 Cell division protein kinase 2 (chains A) XMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN HPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH SHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKY YSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
| ID | Name | Formula | Copies |
|---|---|---|---|
| SCF | 5-(2-fluorophenyl)-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine | C18 H14 F N5 | 1 |
Structure-guided discovery of cyclin-dependent kinase inhibitors. Fischmann, T.O., Hruza, A., Duca, J.S. et al. Biopolymers (2008) 89:372-379. DOI 10.1002/bip.20868 · PubMed
Other PDB entries of the same protein (UniProt P24941 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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