2VIF: SOCS6 SH2 domain

Crystal structure of SOCS6 SH2 domain in complex with a c-KIT phosphopeptide. Determined by X-ray diffraction at 1.45 Å resolution. Released 25 Dec 2007.

Method: X-ray diffraction
Resolution: 1.45 Å
Organism: HOMO SAPIENS
Chains: 2
Atoms: 1,305
Mol. weight: 17.33 kDa
Released: 25 Dec 2007

Explore 2VIF in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2VIF contains 5 α-helices and 11 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 4 helices, 9 β-strands

Element	Residues	Length	Sheet
α-helix	372-382	11
β-strand	385	1	1
α-helix	391-397	7
β-strand	406-410	5	1
β-strand	418-424	7	1
β-strand	427-436	10	1
β-strand	439-442	4	1
β-strand	451	1	1
α-helix	454-467	14
β-strand	471-473	3	2
β-strand	483-484	2	2
β-strand	490	1	1
α-helix	491-492	2

Chain P: 1 helix, 2 β-strands

Element	Residues	Length	Sheet
β-strand	568	1	1
β-strand	570-571	2	2
α-helix	572-573	2

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Suppressor of cytokine signalling 6	A	protein	141	HOMO SAPIENS	O14544 (AlphaFold model)
Mast/stem cell growth factor receptor	P	protein	11	HOMO SAPIENS	P10721 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2VIF_1 SUPPRESSOR OF CYTOKINE SIGNALLING 6 (chains A)
SMVQSSGPMDVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLL
SLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIGDSENGAFCYSRSRLP
GSATYPVRLTNPVSRFMQVRS

Sequence of entity 2 (P), FASTA

>2VIF_2 MAST/STEM CELL GROWTH FACTOR RECEPTOR (chains P)
NGNNYVYIDPT

Primary citation

Structural Basis for C-Kit Inhibition by the Suppressor of Cytokine Signaling 6 (Socs6) Ubiquitin Ligase. Zadjali, F., Pike, A.C.W., Vesterlund, M. et al. J Biol Chem (2011) 286:480. DOI 10.1074/JBC.M110.173526 · PubMed

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