Factor inhibiting hif-1 alpha with pyridine 2,4 dicarboxylic acid. Determined by X-ray diffraction at 2.12 Å resolution. Released 24 Nov 2009.
Explore 2W0X in 3D Show helices and sheets RCSB PDB PDBe
2W0X contains 22 α-helices and 23 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 16-17 | 2 | |
| β-strand | 18 | 1 | 1 |
| α-helix | 19 | 1 | |
| α-helix | 20-22 | 3 | |
| β-strand | 25 | 1 | 1 |
| α-helix | 29-31 | 3 | |
| β-strand | 39-41 | 3 | 2 |
| α-helix | 42-43 | 2 | |
| β-strand | 44-45 | 2 | 3 |
| α-helix | 50-57 | 8 | |
| β-strand | 62-64 | 3 | 3 |
| α-helix | 71-75 | 5 | |
| α-helix | 78-84 | 7 | |
| β-strand | 90-95 | 6 | 3 |
| β-strand | 99 | 1 | 2 |
| α-helix | 105-110 | 6 | |
| β-strand | 119-123 | 5 | 3 |
| α-helix | 125-137 | 13 | |
| β-strand | 143-149 | 7 | 3 |
| α-helix | 156-163 | 8 | |
| α-helix | 167-176 | 10 | |
| β-strand | 182-184 | 3 | 3 |
| β-strand | 186-190 | 5 | 3 |
| β-strand | 195-199 | 5 | 2 |
| β-strand | 204-211 | 8 | 3 |
| β-strand | 214-219 | 6 | 2 |
| α-helix | 221-223 | 3 | |
| α-helix | 224-227 | 4 | |
| β-strand | 229 | 1 | 4 |
| β-strand | 230 | 1 | 5 |
| α-helix | 231 | 1 | |
| β-strand | 237 | 1 | 5 |
| β-strand | 239 | 1 | 2 |
| β-strand | 240 | 1 | 4 |
| α-helix | 253-257 | 5 | |
| β-strand | 260-265 | 6 | 2 |
| β-strand | 270-273 | 4 | 3 |
| β-strand | 278-283 | 6 | 2 |
| α-helix | 284 | 1 | |
| β-strand | 290-297 | 8 | 3 |
| α-helix | 298-303 | 6 | |
| α-helix | 310-311 | 2 | |
| α-helix | 312-330 | 19 | |
| α-helix | 333-335 | 3 | |
| α-helix | 336-344 | 9 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Hypoxia-inducible factor 1 alpha inhibitor | A | protein | 349 | HOMO SAPIENS | Q9NWT6 (AlphaFold model) |
>2W0X_1 HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR (chains A) MAATAAEAVASGSGEPREEAGALGPAWDESQLRSYSFPTRPIPRLSQSDPRAEELIENEE PVVLTDTNLVYPALKWDLEYLQENIGNGDFSVYSASTHKFLYYDEKKMANFQNFKPRSNR EEMKFHEFVEKLQDIQQRGGEERLYLQQTLNDTVGRKIVMDFLGFNWNWINKQQGKRGWG QLTSNLLLIGMEGNVTPAHYDEQQNFFAQIKGYKRCILFPPDQFECLYPYPVHHPCDRQS QVDFDNPDYERFPNFQNVVGYETVVGPGDVLYIPMYWWHHIESLLNGGITITVNFWYKGA PTPKRIEYPLKAHQKVAIMRNIEKMLGEALGNPQEVGPLLNTMIKGRYN
Water and common crystallization additives (GOL, SO4) are not listed.
Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor. Conejo-Garcia, A., McDonough, M.A., Loenarz, C. et al. Bioorg Med Chem Lett (2010) 20:6125-6128. DOI 10.1016/j.bmcl.2010.08.032 · PubMed
Other PDB entries of the same protein (UniProt Q9NWT6 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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