Crystal structure of the human PNKP FHA domain in complex with an XRCC1-derived phosphopeptide. Determined by X-ray diffraction at 1.85 Å resolution. Released 3 Feb 2009.
Explore 2W3O in 3D Show helices and sheets RCSB PDB PDBe
2W3O contains 9 α-helices and 24 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 10-13 | 4 | 1 |
| α-helix | 14 | 1 | |
| α-helix | 20-21 | 2 | |
| β-strand | 22-23 | 2 | 1 |
| α-helix | 24-25 | 2 | |
| β-strand | 30-33 | 4 | 2 |
| β-strand | 36 | 1 | 3 |
| β-strand | 41 | 1 | 3 |
| β-strand | 51-56 | 6 | 2 |
| β-strand | 61-66 | 6 | 2 |
| α-helix | 71-72 | 2 | |
| β-strand | 73-74 | 2 | 1 |
| β-strand | 77-78 | 2 | 1 |
| β-strand | 84-88 | 5 | 2 |
| β-strand | 92-96 | 5 | 1 |
| β-strand | 99-106 | 8 | 1 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 9-13 | 5 | 4 |
| α-helix | 14 | 1 | |
| α-helix | 20-21 | 2 | |
| β-strand | 22-23 | 2 | 4 |
| β-strand | 30-33 | 4 | 5 |
| β-strand | 36 | 1 | 6 |
| β-strand | 41 | 1 | 6 |
| β-strand | 51-56 | 6 | 5 |
| β-strand | 61-66 | 6 | 5 |
| α-helix | 71-72 | 2 | |
| β-strand | 73-74 | 2 | 4 |
| β-strand | 77-78 | 2 | 4 |
| β-strand | 84-88 | 5 | 5 |
| β-strand | 92-96 | 5 | 4 |
| β-strand | 99-107 | 9 | 4 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 518-521 | 4 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Bifunctional polynucleotide phosphatase/kinase | A, B | protein | 113 | HOMO SAPIENS | Q96T60 (AlphaFold model) |
| DNA repair protein XRCC1 | C, D | protein | 8 | HOMO SAPIENS | P18887 (AlphaFold model) |
>2W3O_1 BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE (chains A, B) GPHMGEVEAPGRLWLESPPGEAPPIFLPSDGQALVLGRGPLTQVTDRKCSRTQVELVADP ETRTVAVKQLGVNPSTTGTQELKPGLEGSLGVGDTLYLVNGEHPLTLRWEETR
>2W3O_2 DNA REPAIR PROTEIN XRCC1 (chains C, D) YAGSTDEN
| ID | Name | Formula | Copies |
|---|---|---|---|
| CA | Calcium ion | Ca | 6 |
Specific Recognition of a Multiply Phosphorylated Motif in the DNA Repair Scaffold Xrcc1 by the Fha Domain of Human Pnk. Ali, A.A.E., Jukes, R.M., Pearl, L.H. et al. Nucleic Acids Res (2009) 37:1701. DOI 10.1093/NAR/GKN1086 · PubMed
Other PDB entries of the same protein (UniProt Q96T60 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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