2YPB: SCL:E47 complex

Structure of the SCL:E47 complex bound to DNA. Determined by X-ray diffraction at 2.87 Å resolution. Released 31 Jul 2013.

Method: X-ray diffraction
Resolution: 2.87 Å
Organism: HOMO SAPIENS
Chains: 4
Atoms: 1,622
Mol. weight: 27.1 kDa
Released: 31 Jul 2013

Explore 2YPB in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2YPB contains 5 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	182-184	3
α-helix	185-213	29
α-helix	225-246	22

Chain B: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	539-577	39
α-helix	585-603	19

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
T-cell acute lymphocytic leukemia protein 1	A	protein	91	HOMO SAPIENS	P17542 (AlphaFold model)
Transcription factor E2-alpha	B	protein	82	HOMO SAPIENS	P15923 (AlphaFold model)
Ebox forward	E	DNA	11	HOMO SAPIENS
Ebox reverse	F	DNA	11	HOMO SAPIENS

Sequence of entity 1 (A), FASTA

>2YPB_1 T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1 (chains A)
MGSSHHHHHHSQDPEISDGPHTKVVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKK
LSKNEILRLAMKYINFLAKLLNDQEEEGTQR

Sequence of entity 2 (B), FASTA

>2YPB_2 TRANSCRIPTION FACTOR E2-ALPHA (chains B)
MADLSLEEKDLRDRERRMANNARERVRVRDINEAFRELGRMCQMHLKSDKAQTKLLILQQ
AVQVILGLEQQVRERNLNPKAA

Sequence of entity 3 (E), FASTA

>2YPB_3 EBOX FORWARD (chains E)
ACCATCTGTTC

Sequence of entity 4 (F), FASTA

>2YPB_4 EBOX REVERSE (chains F)
GAACAGATGGT

Primary citation

Structural Basis for Lmo2-Driven Recruitment of the Scl:E47bHLH Heterodimer to Hematopoietic-Specific Transcriptional Targets. El Omari, K., Hoosdally, S.J., Tuladhar, K. et al. Cell Rep (2013) 4:135. DOI 10.1016/J.CELREP.2013.06.008 · PubMed

Other PDB entries of the same protein (UniProt P17542 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2YPA 2.8 Å, Structure of the SCL:E47:LMO2:LDB1 complex bound to DNA

Browse structure collections

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