2ZVX: Pancreatic trypsin inhibitor

Structure of a BPTI-[5,55] variant containing Gly/Val at the 14/38th positions. Determined by X-ray diffraction at 1.09 Å resolution. Released 13 Oct 2009.

Method: X-ray diffraction
Resolution: 1.09 Å
Organism: Bos taurus
Chains: 2
Atoms: 1,026
Mol. weight: 13.08 kDa
Released: 13 Oct 2009

Explore 2ZVX in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2ZVX contains 5 α-helices and 6 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	8-9	2
β-strand	18-24	7	1
β-strand	29-35	7	1
β-strand	45	1	1
α-helix	48-55	8

Chain B: 3 helices, 3 β-strands

Element	Residues	Length	Sheet
α-helix	3-6	4
α-helix	8-9	2
β-strand	18-24	7	2
β-strand	29-35	7	2
β-strand	45	1	2
α-helix	48-55	8

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Pancreatic trypsin inhibitor	A, B	protein	58	Bos taurus	P00974 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>2ZVX_1 Pancreatic trypsin inhibitor (chains A, B)
RPDFCLEPPYTGPGKARIIRYFYNAKAGLAQTFVYGGVRAKRNNFKSAEDALRTCGGA

Primary citation

Thermodynamic and structural analysis of highly stabilized BPTIs by single and double mutations. Islam, M.M., Sohya, S., Noguchi, K. et al. Proteins (2009) 77:962-970. DOI 10.1002/prot.22522 · PubMed

Other PDB entries of the same protein (UniProt P00974 (AlphaFold model), which also has an AlphaFold model), best resolution first:

1G6X 0.86 Å, Ultra high resolution structure of bovine pancreatic trypsin inhibitor (BPTI) mutant…
1K6U 1.0 Å, Crystal Structure of Cyclic Bovine Pancreatic Trypsin Inhibitor
5PTI 1.0 Å, Structure of bovine pancreatic trypsin inhibitor. Results of joint neutron and X-ray…
1BPI 1.09 Å, The structure of bovine pancreatic trypsin inhibitor at 125K: definition of…
2ZJX 1.09 Å, Bovine pancreatic trypsin inhibitor (BPTI) containing only the [5,55] disulfide bond
5XX2 1.12 Å, A BPTI-[5,55] variant with C14GA38L mutations
5XX3 1.12 Å, A BPTI-[5,55] variant with C14GA38G mutations
7PH1 1.18 Å, Trypsin in complex with BPTI mutant (2S)-2-amino-4-monofluorobutanoic acid
9PTI 1.22 Å, Basic pancreatic trypsin inhibitor (met 52 oxidized)
4Y0Y 1.25 Å, Trypsin in complex with with BPTI
3P95 1.3 Å, Human mesotrypsin complexed with bovine pancreatic trypsin inhibitor variant…
3WNY 1.3 Å, A simplified BPTI variant with poly Lys amino acid tag (C3K) at the C-terminus

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