36BL: 26S proteasome regulatory subunit 7 homolog
yeast 26S proteasome base assembly intermediate, base-Rpn14-Hsm3-Nas6(2) with Rpt4-EQ. Determined by electron microscopy at 3.91 Å resolution. Released 19 Aug 2026.
- Method
- Electron microscopy
- Resolution
- 3.91 Å
- Organism
- Saccharomyces cerevisiae
- Chains
- 12
- Atoms
- 41,522
- Mol. weight
- 654.64 kDa
- Ligands
- ATP
- Released
- 19 Aug 2026
Explore 36BL in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
36BL contains 303 α-helices and 170 β-strands across 12 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 26 helices, 17 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 46-65 | 20 | |
| α-helix | 71-73 | 3 | |
| β-strand | 76 | 1 | 1 |
| α-helix | 77-78 | 2 | |
| α-helix | 79-81 | 3 | |
| α-helix | 88-91 | 4 | |
| β-strand | 97-107 | 11 | 2 |
| β-strand | 143-148 | 6 | 2 |
| β-strand | 154-157 | 4 | 2 |
| β-strand | 159 | 1 | 2 |
| α-helix | 165-167 | 3 | |
| β-strand | 173-176 | 4 | 2 |
| β-strand | 183-186 | 4 | 2 |
| α-helix | 194-197 | 4 | |
| β-strand | 199-201 | 3 | 3 |
| α-helix | 208-210 | 3 | |
| α-helix | 215-225 | 11 | |
| α-helix | 227-230 | 4 | |
| α-helix | 232-238 | 7 | |
| α-helix | 240-243 | 4 | |
| β-strand | 245-249 | 5 | 3 |
| α-helix | 256-266 | 11 | |
| β-strand | 270-275 | 6 | 3 |
| α-helix | 276-277 | 2 | |
| α-helix | 278-282 | 5 | |
| α-helix | 287-300 | 14 | |
| β-strand | 304-309 | 6 | 3 |
| α-helix | 312-315 | 4 | |
| β-strand | 316 | 1 | 4 |
| α-helix | 317-318 | 2 | |
| α-helix | 328-342 | 15 | |
| β-strand | 349-355 | 7 | 3 |
| α-helix | 358-360 | 3 | |
| β-strand | 361 | 1 | 4 |
| β-strand | 373-376 | 4 | 3 |
| α-helix | 378-380 | 3 | |
| α-helix | 382-392 | 11 | |
| β-strand | 398 | 1 | 5 |
| α-helix | 404-409 | 6 | |
| α-helix | 416-432 | 17 | |
| β-strand | 438 | 1 | 5 |
| α-helix | 440-447 | 8 | |
| α-helix | 448-452 | 5 | |
Chain B: 19 helices, 14 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 56-82 | 27 | |
| α-helix | 88-100 | 13 | |
| β-strand | 104-114 | 11 | 2 |
| β-strand | 117-121 | 5 | 2 |
| β-strand | 128-132 | 5 | 2 |
| β-strand | 136 | 1 | 1 |
| β-strand | 146-150 | 5 | 2 |
| β-strand | 156-159 | 4 | 2 |
| α-helix | 167-170 | 4 | |
| β-strand | 172-174 | 3 | 6 |
| α-helix | 181-183 | 3 | |
| α-helix | 188-194 | 7 | |
| α-helix | 195-199 | 5 | |
| α-helix | 200-203 | 4 | |
| α-helix | 205-210 | 6 | |
| α-helix | 214-216 | 3 | |
| β-strand | 218-223 | 6 | 6 |
| α-helix | 229-240 | 12 | |
| α-helix | 242 | 1 | |
| β-strand | 243-248 | 6 | 6 |
| α-helix | 249-254 | 6 | |
| α-helix | 260-273 | 14 | |
| β-strand | 277-282 | 6 | 6 |
| α-helix | 285-289 | 5 | |
| α-helix | 299-315 | 17 | |
| β-strand | 322-328 | 7 | 6 |
| α-helix | 331-333 | 3 | |
| β-strand | 346-350 | 5 | 6 |
| α-helix | 355-366 | 12 | |
| β-strand | 371 | 1 | 7 |
| α-helix | 389-405 | 17 | |
| β-strand | 411 | 1 | 7 |
| α-helix | 413-428 | 16 | |
Chain C: 52 helices, 13 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 41-57 | 17 | |
| α-helix | 61-63 | 3 | |
| α-helix | 64-79 | 16 | |
| α-helix | 87-92 | 6 | |
| α-helix | 96-105 | 10 | |
| α-helix | 109-125 | 17 | |
| α-helix | 133-140 | 8 | |
| α-helix | 147-149 | 3 | |
| α-helix | 151-177 | 27 | |
| α-helix | 197-213 | 17 | |
| α-helix | 217-226 | 10 | |
| α-helix | 230-232 | 3 | |
| α-helix | 234-236 | 3 | |
| α-helix | 242-252 | 11 | |
| α-helix | 260-274 | 15 | |
| α-helix | 278-288 | 11 | |
| α-helix | 291-299 | 9 | |
| α-helix | 304-317 | 14 | |
| α-helix | 327-330 | 4 | |
| α-helix | 335-345 | 11 | |
| α-helix | 355-358 | 4 | |
| α-helix | 366-371 | 6 | |
| α-helix | 376-390 | 15 | |
| α-helix | 404-409 | 6 | |
| α-helix | 414-425 | 12 | |
| α-helix | 431-437 | 7 | |
| α-helix | 438-441 | 4 | |
| α-helix | 445-458 | 14 | |
| α-helix | 469-478 | 10 | |
| α-helix | 483-496 | 14 | |
| α-helix | 503-514 | 12 | |
| α-helix | 520-533 | 14 | |
| α-helix | 540-552 | 13 | |
| α-helix | 557-559 | 3 | |
| α-helix | 563-573 | 11 | |
| α-helix | 578-581 | 4 | |
| α-helix | 582-589 | 8 | |
| α-helix | 596-607 | 12 | |
| α-helix | 614-624 | 11 | |
| α-helix | 626-627 | 2 | |
| α-helix | 724-746 | 23 | |
| α-helix | 747-749 | 3 | |
| α-helix | 751-767 | 17 | |
| α-helix | 770-783 | 14 | |
| α-helix | 790-799 | 10 | |
| α-helix | 805-818 | 14 | |
| α-helix | 825-837 | 13 | |
| α-helix | 842-855 | 14 | |
| α-helix | 857-860 | 4 | |
| β-strand | 862-863 | 2 | 8 |
| β-strand | 867 | 1 | 9 |
| β-strand | 873 | 1 | 9 |
| α-helix | 875-887 | 13 | |
| α-helix | 891-896 | 6 | |
| α-helix | 898-906 | 9 | |
| β-strand | 909-910 | 2 | 8 |
| β-strand | 912-916 | 5 | 10 |
| β-strand | 922 | 1 | 10 |
| β-strand | 926-932 | 7 | 11 |
| β-strand | 945-952 | 8 | 11 |
| β-strand | 955-956 | 2 | 10 |
| β-strand | 961-965 | 5 | 11 |
| β-strand | 970-972 | 3 | 12 |
| β-strand | 979-982 | 4 | 10 |
| β-strand | 983-985 | 3 | 12 |
Chain D: 40 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-6 | 4 | |
| α-helix | 9-20 | 12 | |
| α-helix | 29-42 | 14 | |
| α-helix | 52-64 | 13 | |
| α-helix | 73-81 | 9 | |
| α-helix | 89-95 | 7 | |
| α-helix | 98-105 | 8 | |
| α-helix | 110-121 | 12 | |
| α-helix | 128-131 | 4 | |
| α-helix | 134-142 | 9 | |
| α-helix | 150-163 | 14 | |
| α-helix | 167-171 | 5 | |
| α-helix | 172-176 | 5 | |
| α-helix | 178-187 | 10 | |
| α-helix | 190-206 | 17 | |
| α-helix | 214-217 | 4 | |
| α-helix | 219-220 | 2 | |
| α-helix | 221-227 | 7 | |
| α-helix | 231-250 | 20 | |
| α-helix | 254-256 | 3 | |
| α-helix | 257-260 | 4 | |
| α-helix | 264-272 | 9 | |
| α-helix | 278-283 | 6 | |
| α-helix | 285-296 | 12 | |
| α-helix | 304-309 | 6 | |
| α-helix | 310-314 | 5 | |
| α-helix | 323-329 | 7 | |
| α-helix | 332-337 | 6 | |
| α-helix | 340-346 | 7 | |
| α-helix | 351-353 | 3 | |
| α-helix | 354-360 | 7 | |
| α-helix | 364-369 | 6 | |
| α-helix | 376-380 | 5 | |
| α-helix | 384-394 | 11 | |
| α-helix | 398-407 | 10 | |
| α-helix | 409-416 | 8 | |
| α-helix | 427-441 | 15 | |
| α-helix | 445-448 | 4 | |
| α-helix | 449-451 | 3 | |
| α-helix | 452-464 | 13 | |
Chain I: 21 helices, 18 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 19-66 | 48 | |
| α-helix | 68-69 | 2 | |
| β-strand | 70-78 | 9 | 2 |
| β-strand | 83-88 | 6 | 2 |
| β-strand | 92-98 | 7 | 2 |
| α-helix | 104-106 | 3 | |
| β-strand | 112-115 | 4 | 2 |
| β-strand | 122-125 | 4 | 2 |
| α-helix | 132-137 | 6 | |
| β-strand | 138 | 1 | 13 |
| α-helix | 147-149 | 3 | |
| α-helix | 154-160 | 7 | |
| α-helix | 161-165 | 5 | |
| α-helix | 166-169 | 4 | |
| α-helix | 172-177 | 6 | |
| α-helix | 180-182 | 3 | |
| β-strand | 184-188 | 5 | 13 |
| α-helix | 195-205 | 11 | |
| β-strand | 209-214 | 6 | 13 |
| α-helix | 216-218 | 3 | |
| α-helix | 225-239 | 15 | |
| β-strand | 243-248 | 6 | 13 |
| β-strand | 255 | 1 | 14 |
| α-helix | 256-257 | 2 | |
| α-helix | 266-281 | 16 | |
| β-strand | 289-292 | 4 | 13 |
| β-strand | 294 | 1 | 13 |
| β-strand | 300 | 1 | 14 |
| α-helix | 302-305 | 4 | |
| β-strand | 307 | 1 | 15 |
| β-strand | 309 | 1 | 15 |
| β-strand | 312-315 | 4 | 13 |
| α-helix | 317-319 | 3 | |
| α-helix | 321-331 | 11 | |
| β-strand | 337 | 1 | 16 |
| α-helix | 343-349 | 7 | |
| α-helix | 355-371 | 17 | |
| β-strand | 377 | 1 | 16 |
| α-helix | 379-395 | 17 | |
Chain J: 22 helices, 15 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 47-90 | 44 | |
| α-helix | 93 | 1 | |
| β-strand | 94-102 | 9 | 2 |
| β-strand | 107-112 | 6 | 2 |
| β-strand | 117-122 | 6 | 2 |
| α-helix | 123 | 1 | |
| α-helix | 128-130 | 3 | |
| β-strand | 136-140 | 5 | 2 |
| β-strand | 146-149 | 4 | 2 |
| α-helix | 152-155 | 4 | |
| β-strand | 161 | 1 | 17 |
| α-helix | 178-184 | 7 | |
| α-helix | 185-189 | 5 | |
| α-helix | 190-193 | 4 | |
| α-helix | 195-201 | 7 | |
| α-helix | 204-206 | 3 | |
| β-strand | 208-212 | 5 | 17 |
| α-helix | 219-229 | 11 | |
| β-strand | 233-238 | 6 | 17 |
| α-helix | 240-242 | 3 | |
| α-helix | 249-263 | 15 | |
| β-strand | 267-272 | 6 | 17 |
| α-helix | 274-276 | 3 | |
| β-strand | 279 | 1 | 18 |
| α-helix | 287-304 | 18 | |
| β-strand | 312-318 | 7 | 17 |
| α-helix | 321-323 | 3 | |
| β-strand | 324 | 1 | 18 |
| α-helix | 326-329 | 4 | |
| β-strand | 336-339 | 4 | 17 |
| α-helix | 340-342 | 3 | |
| α-helix | 346-358 | 13 | |
| β-strand | 362 | 1 | 19 |
| α-helix | 368-372 | 5 | |
| α-helix | 380-396 | 17 | |
| β-strand | 402 | 1 | 19 |
| α-helix | 404-416 | 13 | |
Chain K: 19 helices, 15 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 48-98 | 51 | |
| β-strand | 103-111 | 9 | 2 |
| β-strand | 117-121 | 5 | 2 |
| β-strand | 126-129 | 4 | 2 |
| β-strand | 131 | 1 | 2 |
| α-helix | 137-139 | 3 | |
| β-strand | 145-149 | 5 | 2 |
| β-strand | 155-158 | 4 | 2 |
| α-helix | 159-164 | 6 | |
| α-helix | 166-171 | 6 | |
| α-helix | 180-182 | 3 | |
| α-helix | 187-202 | 16 | |
| α-helix | 205-210 | 6 | |
| α-helix | 212-215 | 4 | |
| β-strand | 217-221 | 5 | 20 |
| α-helix | 228-239 | 12 | |
| β-strand | 242-247 | 6 | 20 |
| α-helix | 248-251 | 4 | |
| α-helix | 258-272 | 15 | |
| β-strand | 276-281 | 6 | 20 |
| α-helix | 283-285 | 3 | |
| β-strand | 288 | 1 | 21 |
| α-helix | 289-290 | 2 | |
| α-helix | 296-313 | 18 | |
| β-strand | 321-327 | 7 | 20 |
| α-helix | 330-332 | 3 | |
| β-strand | 333 | 1 | 21 |
| β-strand | 345-348 | 4 | 20 |
| α-helix | 354-366 | 13 | |
| β-strand | 370 | 1 | 22 |
| α-helix | 376-382 | 7 | |
| α-helix | 388-404 | 17 | |
| β-strand | 410 | 1 | 22 |
| α-helix | 412-426 | 15 | |
Chain L: 2 helices, 9 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 8-11 | 4 | 23 |
| β-strand | 12-17 | 6 | 24 |
| β-strand | 23-26 | 4 | 24 |
| β-strand | 31-37 | 7 | 23 |
| α-helix | 41-43 | 3 | |
| β-strand | 46-52 | 7 | 23 |
| β-strand | 65-68 | 4 | 23 |
| β-strand | 74-78 | 5 | 24 |
| β-strand | 86-90 | 5 | 24 |
| β-strand | 96-101 | 6 | 24 |
| α-helix | 116-129 | 14 | |
4 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| 26S proteasome regulatory subunit 7 homolog | A | protein | 467 | Saccharomyces cerevisiae | P33299 (AlphaFold model) |
| 26S proteasome regulatory subunit 4 homolog | B | protein | 437 | Saccharomyces cerevisiae | P40327 (AlphaFold model) |
| 26S proteasome regulatory subunit RPN1 | C | protein | 993 | Saccharomyces cerevisiae | P38764 (AlphaFold model) |
| DNA mismatch repair protein HSM3 | D | protein | 480 | Saccharomyces cerevisiae | P38348 (AlphaFold model) |
| 26S proteasome regulatory subunit 8 homolog | I | protein | 405 | Saccharomyces cerevisiae | Q01939 |
| 26S proteasome regulatory subunit 6B homolog | J | protein | 428 | Saccharomyces cerevisiae | P33298 |
| 26S proteasome subunit RPT4 | K | protein | 437 | Saccharomyces cerevisiae | P53549 |
| 26S proteasome regulatory subunit RPN13 | L | protein | 156 | Saccharomyces cerevisiae | O13563 |
| 26S proteasome regulatory subunit RPN14 | M | protein | 417 | Saccharomyces cerevisiae | P53196 |
| Probable 26S proteasome regulatory subunit p28 | N | protein | 228 | Saccharomyces cerevisiae | P50086 |
| 26S proteasome regulatory subunit 6A | P | protein | 434 | Saccharomyces cerevisiae | P33297 |
| 26S proteasome regulatory subunit RPN2 | Z | protein | 945 | Saccharomyces cerevisiae | P32565 |
Sequence of entity 1 (A), FASTA
>36BL_1 26S proteasome regulatory subunit 7 homolog (chains A)
MPPKEDWEKYKAPLEDDDKKPDDDKIVPLTEGDIQVLKSYGAAPYAAKLKQTENDLKDIE
ARIKEKAGVKESDTGLAPSHLWDIMGDRQRLGEEHPLQVARCTKIIKGNGESDETTTDNN
NSGNSNSNSNQQSTDADEDDEDAKYVINLKQIAKFVVGLGERVSPTDIEEGMRVGVDRSK
YNIELPLPPRIDPSVTMMTVEEKPDVTYSDVGGCKDQIEKLREVVELPLLSPERFATLGI
DPPKGILLYGPPGTGKTLCARAVANRTDATFIRVIGSELVQKYVGEGARMVRELFEMART
KKACIIFFDEIDAVGGARFDDGAGGDNEVQRTMLELITQLDGFDPRGNIKVMFATNRPNT
LDPALLRPGRIDRKVEFSLPDLEGRANIFRIHSKSMSVERGIRWELISRLCPNSTGAELR
SVCTEAGMFAIRARRKVATEKDFLKAVDKVISGYKKFSSTSRYMQYN
Sequence of entity 2 (B), FASTA
>36BL_2 26S proteasome regulatory subunit 4 homolog (chains B)
MGQGVSSGQDKKKKKGSNQKPKYEPPVQSKFGRKKRKGGPATAEKLPNIYPSTRCKLKLL
RMERIKDHLLLEEEFVSNSEILKPFEKKQEEEKKQLEEIRGNPLSIGTLEEIIDDDHAIV
TSPTMPDYYVSILSFVDKELLEPGCSVLLHHKTMSIVGVLQDDADPMVSVMKMDKSPTES
YSDIGGLESQIQEIKESVELPLTHPELYEEMGIKPPKGVILYGAPGTGKTLLAKAVANQT
SATFLRIVGSELIQKYLGDGPRLCRQIFKVAGENAPSIVFIDEIDAIGTKRYDSNSGGER
EIQRTMLELLNQLDGFDDRGDVKVIMATNKIETLDPALIRPGRIDRKILFENPDLSTKKK
ILGIHTSKMNLSEDVNLETLVTTKDDLSGADIQAMCTEAGLLALRERRMQVTAEDFKQAK
ERVMKNKVEENLEGLYL
Sequence of entity 3 (C), FASTA
>36BL_3 26S proteasome regulatory subunit RPN1 (chains C)
MVDESDKKQQTIDEQSQISPEKQTPNKKDKKKEEEEQLSEEDAKLKTDLELLVERLKEDD
SSLYEASLNALKESIKNSTSSMTAVPKPLKFLRPTYPDLCSIYDKWTDPNLKSSLADVLS
ILAMTYSENGKHDSLRYRLLSDVSDFEGWGHEYIRHLALEIGEVYNDQVEKDAEDETSSD
GSKSDGSAATSGFEFSKEDTLRLCLDIVPYFLKHNGEEDAVDLLLEIESIDKLPQFVDEN
TFQRVCQYMVACVPLLPPPEDVAFLKTAYSIYLSQNELTDAIALAVRLGEEDMIRSVFDA
TSDPVMHKQLAYILAAQKTSFEYEGVQDIIGNGKLSEHFLYLAKELNLTGPKVPEDIYKS
HLDNSKSVFSSAGLDSAQQNLASSFVNGFLNLGYCNDKLIVDNDNWVYKTKGDGMTSAVA
SIGSIYQWNLDGLQQLDKYLYVDEPEVKAGALLGIGISASGVHDGEVEPALLLLQDYVTN
PDTKISSAAILGLGIAFAGSKNDEVLGLLLPIAASTDLPIETAAMASLALAHVFVGTCNG
DITTSIMDNFLERTAIELKTDWVRFLALALGILYMGQGEQVDDVLETISAIEHPMTSAIE
VLVGSCAYTGTGDVLLIQDLLHRLTPKNVKGEEDADEEETAEGQTNSISDFLGEQVNEPT
KNEEAEIEVDEMEVDAEGEEVEVKAEITEKKNGESLEGEEIKSEEKKGKSSDKDATTDGK
NDDEEEEKEAGIVDELAYAVLGIALIALGEDIGKEMSLRHFGHLMHYGNEHIRRMVPLAM
GIVSVSDPQMKVFDTLTRFSHDADLEVSMNSIFAMGLCGAGTNNARLAQLLRQLASYYSR
EQDALFITRLAQGLLHLGKGTMTMDVFNDAHVLNKVTLASILTTAVGLVSPSFMLKHHQL
FYMLNAGIRPKFILALNDEGEPIKVNVRVGQAVETVGQAGRPKKITGWITQSTPVLLNHG
ERAELETDEYISYTSHIEGVVILKKNPDYREEE
Sequence of entity 4 (D), FASTA
>36BL_4 DNA mismatch repair protein HSM3 (chains D)
MSEKETNYVENLLTQLENELNEDNLPEDINTLLRKCSLNLVTVVSLPDMDVKPLLATIKR
FLTSNVSYDSLNYDYLLDVVDKLVPMADFDDVLEVYSAEDLVKALRSEIDPLKVAACRVI
ENSQPKGLFATSNIIDILLDILFDEKVENDKLITAIEKALERLSTDELIRRRLFDNNLPY
LVSVKGRMETVSFVRLIDFLTIEFQFISGPEFKDIIFCFTKEEILKSVEDILVFIELVNY
YTKFLLEIRNQDKYWALRHVKKILPVFAQLFEDTENYPDVRAFSTNCLLQLFAEVSRIEE
DEYSLFKTMDKDSLKIGSEAKLITEWLELINPQYLVKYHKDVVENYFHVSGYSIGMLRNL
SADEECFNAIRNKFSAEIVLRLPYLEQMQVVETLTRYEYTSKFLLNEMPKVMGSLIGDGS
AGAIIDLETVHYRNSALRNLLDKGEEKLSVWYEPLLREYSKAVNGKNYSTGSETKIADCR
Sequence of entity 5 (I), FASTA
>36BL_5 26S proteasome regulatory subunit 8 homolog (chains I)
MTAAVTSSNIVLETHESGIKPYFEQKIQETELKIRSKTENVRRLEAQRNALNDKVRFIKD
ELRLLQEPGSYVGEVIKIVSDKKVLVKVQPEGKYIVDVAKDINVKDLKASQRVCLRSDSY
MLHKVLENKADPLVSLMMVEKVPDSTYDMVGGLTKQIKEIKEVIELPVKHPELFESLGIA
QPKGVILYGPPGTGKTLLARAVAHHTDCKFIRVSGAELVQKYIGEGSRMVRELFVMAREH
APSIIFMDEIDSIGSTRVEGSGGGDSEVQRTMLELLNQLDGFETSKNIKIIMATNRLDIL
DPALLRPGRIDRKIEFPPPSVAARAEILRIHSRKMNLTRGINLRKVAEKMNGCSGADVKG
VCTEAGMYALRERRIHVTQEDFELAVGKVMNKNQETAISVAKLFK
Sequence of entity 6 (J), FASTA
>36BL_6 26S proteasome regulatory subunit 6B homolog (chains J)
MEELGIVTPVEKAVEEKPAVKSYASLLAQLNGTVNNNSALSNVNSDIYFKLKKLEKEYEL
LTLQEDYIKDEQRHLKRELKRAQEEVKRIQSVPLVIGQFLEPIDQNTGIVSSTTGMSYVV
RILSTLDRELLKPSMSVALHRHSNALVDILPPDSDSSISVMGENEKPDVTYADVGGLDMQ
KQEIREAVELPLVQADLYEQIGIDPPRGVLLYGPPGTGKTMLVKAVANSTKAAFIRVNGS
EFVHKYLGEGPRMVRDVFRLARENAPSIIFIDEVDSIATKRFDAQTGSDREVQRILIELL
TQMDGFDQSTNVKVIMATNRADTLDPALLRPGRLDRKIEFPSLRDRRERRLIFGTIASKM
SLAPEADLDSLIIRNDSLSGAVIAAIMQEAGLRAVRKNRYVILQSDLEEAYATQVKTDNT
VDKFDFYK
Sequence of entity 7 (K), FASTA
>36BL_7 26S proteasome subunit RPT4 (chains K)
MSEEQDPLLAGLGETSGDNHTQQSHEQQPEQPQETEEHHEEEPSRVDPEQEAHNKALNQF
KRKLLEHRRYDDQLKQRRQNIRDLEKLYDKTENDIKALQSIGQLIGEVMKELSEEKYIVK
ASSGPRYIVGVRNSVDRSKLKKGVRVTLDITTLTIMRILPRETDPLVYNMTSFEQGEITF
DGIGGLTEQIRELREVIELPLKNPEIFQRVGIKPPKGVLLYGPPGTGKTLLAKAVAATIG
ANFIFSPASGIVDKYIGESARIIREMFAYAKEHEPCIIFMDQVDAIGGRRFSEGTSADRE
IQRTLMELLTQMDGFDNLGQTKIIMATNRPDTLDPALLRPGRLDRKVEIPLPNEAGRLEI
FKIHTAKVKKTGEFDFEAAVKMSDGFNGADIRNCATEAGFFAIRDDRDHINPDDLMKAVR
KVAEVKKLEGTIEYQKL
Sequence of entity 8 (L), FASTA
>36BL_8 26S proteasome regulatory subunit RPN13 (chains L)
MSMSSTVIKFRAGVCEYNEDSRLCTPIPVQGEIEIKPNEEEELGFWDFEWRPTEKPVGRE
LDPISLILIPGETMWVPIKSSKSGRIFALVFSSNERYFFWLQEKNSGNLPLNELSAKDKE
IYNKMIGVLNNSSESDEEESNDEKQKAQDVDVSMQD
Sequence of entity 9 (M), FASTA
>36BL_9 26S proteasome regulatory subunit RPN14 (chains M)
MTKTITVAHIQYDFKAVLEENDENDDEFYINVDKNLNEIKEHKIVVLGNSRGVDAGKGNT
FEKVGSHLYKARLDGHDFLFNTIIRDGSKMLKRADYTAVDTAKLQMRRFILGTTEGDIKV
LDSNFNLQREIDQAHVSEITKLKFFPSGEALISSSQDMQLKIWSVKDGSNPRTLIGHRAT
VTDIAIIDRGRNVLSASLDGTIRLWECGTGTTIHTFNRKENPHDGVNSIALFVGTDRQLH
EISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKEQTIQLPSKFTCSCNSLTVDGNNA
NYIYAGYENGMLAQWDLRSPECPVGEFLINEGTPINNVYFAAGALFVSSGFDTSIKLDII
SDPESERPAIEFETPTFLVSNDDEVSQFCYVSDDESNGEVLEVGKNNFCALYNLSNP
Sequence of entity 10 (N), FASTA
>36BL_10 Probable 26S proteasome regulatory subunit p28 (chains N)
MSNYPLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKME
NVNLDDYPDDSGWTPFHIACSVGNLEVVKSLYDRPLKPDLNKITNQGVTCLHLAVGKKWF
EVSQFLIENGASVRIKDKFNQIPLHRAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFH
ALAEGHGDAAVLLVEKYGAEYDLVDNKGAKAEDVALNEQVKKFFLNNV
Sequence of entity 11 (P), FASTA
>36BL_11 26S proteasome regulatory subunit 6A (chains P)
MATLEELDAQTLPGDDELDQEILNLSTQELQTRAKLLDNEIRIFRSELQRLSHENNVMLE
KIKDNKEKIKNNRQLPYLVANVVEVMDMNEIEDKENSESTTQGGNVNLDNTAVGKAAVVK
TSSRQTVFLPMVGLVDPDKLKPNDLVGVNKDSYLILDTLPSEFDSRVKAMEVDEKPTETY
SDVGGLDKQIEELVEAIVLPMKRADKFKDMGIRAPKGALMYGPPGTGKTLLARACAAQTN
ATFLKLAAPQLVQMYIGEGAKLVRDAFALAKEKAPTIIFIDELDAIGTKRFDSEKSGDRE
VQRTMLELLNQLDGFSSDDRVKVLAATNRVDVLDPALLRSGRLDRKIEFPLPSEDSRAQI
LQIHSRKMTTDDDINWQELARSTDEFNGAQLKAVTVEAGMIALRNGQSSVKHEDFVEGIS
EVQARKSKSVSFYA
Sequence of entity 12 (Z), FASTA
>36BL_12 26S proteasome regulatory subunit RPN2 (chains Z)
MSLTTAAPLLALLRENQDSVKTYALESINNVVDQLWSEISNELPDIEALYDDDTFSDREM
AALIASKVYYNLGEYESAVKYALAAKDRFDIDEKSQFVETIVSKSIEMYVQEASKQYTKD
EQFYTKDIIDPKLTSIFERMIEKCLKASELKLALGIALEGYRLDIIESALKSKLDQDSTS
ENVKIINYLLTLAITTVTNSKFRSSILRKSFDFLMNMPNCDYLTLNKVVVNLNDAGLALQ
LFKKLKEENDEGLSAQIAFDLVSSASQQLLEILVTELTAQGYDPALLNILSGLPTCDYYN
TFLLNNKNIDIGLLNKSKSSLDGKFSLFHTAVSVANGFMHAGTTDNSFIKANLPWLGKAQ
NWAKFTATASLGVIHKGNLLEGKKVMAPYLPGSRASSRFIKGGSLYGLGLIYAGFGRDTT
DYLKNIIVENSGTSGDEDVDVLLHGASLGIGLAAMGSANIEVYEALKEVLYNDSATSGEA
AALGMGLCMLGTGKPEAIHDMFTYSQETQHGNITRGLAVGLALINYGRQELADDLITKML
ASDESLLRYGGAFTIALAYAGTGNNSAVKRLLHVAVSDSNDDVRRAAVIALGFVLLRDYT
TVPRIVQLLSKSHNAHVRCGTAFALGIACAGKGLQSAIDVLDPLTKDPVDFVRQAAMIAL
SMILIQQTEKLNPQVADINKNFLSVITNKHQEGLAKFGACVAQGIMNAGGRNVTIQLENA
DTGTLDTKSVVGLVMFSQFWYWFPLAHFLSLSFTPTTVIGIRGSDQAIPKFQMNCYAKED
AFSYPRMYEEASGKEVEKVATAVLSTTARAKARAKKTKKEKGPNEEEKKKEHEEKEKERE
TNKKGIKETKENDEEFYKNKYSSKPYKVDNMTRILPQQSRYISFIKDDRFVPVRKFKGNN
GVVVLRDREPKEPVALIETVRQMKDVNAPLPTPFKVDDNVDFPSA
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ATP | Adenosine-5'-triphosphate | C10 H16 N5 O13 P3 | 6 |
Primary citation
Chaperones shape the conformational landscape of 26S-proteasome-base assembly for allosteric ATPase motor activation. Hsieh, H.H., Martin, A. bioRxiv (2026). DOI 10.64898/2026.06.01.729410 · PubMed
Other PDB entries of the same protein (UniProt P33299 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 35ZR 2.99 Å, yeast 26S proteasome base assembly intermediate, Hsm3-Rpt1-Rpt2 (base-Hsm3-Nas6 with…
- 35ZW 3.31 Å, yeast 26S proteasome base assembly intermediate, Hsm3-Rpt1-Rpt2-Rpt3-Rpt4-Rpt5…
- 9CGC 3.61 Å, Yeast 26S proteasome non-substrate-engaged (S1 state)
- 3VLF 3.8 Å, Crystal structure of yeast proteasome interacting protein
- 4A3V 3.8 Å, yeast regulatory particle proteasome assembly chaperone Hsm3 in complex with Rpt1…
- 6J2Q 3.8 Å, Yeast proteasome in Ub-accepted state (C1-b)
- 6J2X 3.8 Å, Yeast proteasome in resting state (C1-a)
- 36BM 3.82 Å, yeast 26S proteasome base assembly intermediate, base-Hsm3-Nas6 with Rpt4-EQ
- 36BD 3.93 Å, yeast 26S proteasome base assembly intermediate, base-Rpn14-Hsm3-Nas6 with Rpt4-EQ
- 5MP9 4.1 Å, 26S proteasome in presence of ATP (s1)
- 6FVT 4.1 Å, 26S proteasome, s1 state
- 6EF3 4.17 Å, Yeast 26S proteasome bound to ubiquitinated substrate (4D motor state)
Browse structure collections
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