Solution Structure of Human SIgA2. Determined by solution scattering. Released 30 Dec 2008.
Explore 3CM9 in 3D Show helices and sheets RCSB PDB PDBe
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Immunoglobulin heavy chain | A, B, C, D | protein | 462 | Homo sapiens | P01877 (AlphaFold model) |
| Secretory component | J | protein | 106 | Homo sapiens | P01833 (AlphaFold model) |
| Immunoglobulin light chain | L, M, N, O | protein | 214 | Homo sapiens | |
| Secretory component | S | protein | 585 | Homo sapiens | P01833 (AlphaFold model) |
>3CM9_1 Immunoglobulin heavy chain (chains A, B, C, D) QVKLLEQSGAEVKKPGASVKVSCKASGYSFTSYGLHWVRQAPGQRLEWMGWISAGTGNTK YSQKFRGRVTFTRDTSATTAYMGLSSLRPEDTAVYYCARDPYGGGKSEFDYWGQGTLVTV SSASPTSPKVFPLSLDSTPQDGNVVVACLVQGFFPQEPLSVTWSESGQNVTARNFPPSQD ASGDLYTTSSQLTLPATQCPDGKSVTCHVKHYTNPSQDVTVPCPVPPPPPCCHPRLSLHR PALEDLLLGSEANLTCTLTGLRDASGATFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPG CAQPWNHGETFTCTAAHPELKTPLTANITKSGNTFRPEVHLLPPPSEELALNELVTLTCL ARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTF SCMVGHEALPLAFTQKTIDRLAGKPTHVNVSVVMAEVDGTCY
>3CM9_2 Secretory component (chains J) PRSPTVVKGVAGSSVAVLCPYNRKESKSIKYWCLWEGAQNGRCPLLVDSEGWVKAQYEGR LSLLEEPGNGTFTVILNQLTSRDAGFYWCLTNGDTLWRTTVEIKII
>3CM9_3 Immunoglobulin light chain (chains L, M, N, O) ELVMTQSPSSLSASVGDRVNIACRASQGISSALAWYQQKPGKAPRLLIYDASNLESGVPS RFSGSGSGTDFTLTISSLQPEDFAIYYCQQFNSYPLTFGGGTKVEIKRTVAAPSVFIFPP SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLT LSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
>3CM9_4 Secretory component (chains S) KSPIFGPEEVNSVEGNSVSITCYYPPTSVNRHTRKYWCRQGARGGCITLISSEGYVSSKY AGRANLTNFPENGTFVVNIAQLSQDDSGRYKCGLGINSRGLSFDVSLEVSQGPGLLNDTK VYTVDLGRTVTINCPFKTENAQKRKSLYKQIGLYPVLVIDSSGYVNPNYTGRIRLDIQGT GQLLFSVVINQLRLSDAGQYLCQAGDDSNSNKKNADLQVLKPEPELVYEDLRGSVTFHCA LGPEVANVAKFLCRQSSGENCDVVVNTLGKRAPAFEGRILLNPQDKDGSFSVVITGLRKE DAGRYLCGAHSDGQLQEGSPIQAWQLFVNEESTIPRSPTVVKGVAGSSVAVLCPYNRKES KSIKYWCLWEGAQNGRCPLLVDSEGWVKAQYEGRLSLLEEPGNGTFTVILNQLTSRDAGF YWCLTNGDTLWRTTVEIKIIEGEPNLKVPGNVTAVLGETLKVPCHFPCKFSSYEKYWCKW NNTGCQALPSQDEGPSKAFVNCDENSRLVSLTLNLVTRADEGWYWCGVKQGHFYGETAAV YVAVEERKAAGSRDVSLAKADAAPDEKVLDSGFREIENKAIQDPR
The nonplanar secretory IgA2 and near planar secretory IgA1 solution structures rationalize their different mucosal immune responses. Bonner, A., Almogren, A., Furtado, P.B. et al. J Biol Chem (2009) 284:5077-5087. DOI 10.1074/jbc.M807529200 · PubMed
Other PDB entries of the same protein (UniProt P01877 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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