3DS4: HIV-1 capsid C-terminal domain mutant

HIV-1 capsid C-terminal domain mutant (L211S) in complex with an inhibitor of particle assembly (CAI). Determined by X-ray diffraction at 1.12 Å resolution. Released 2 Sept 2008.

Method: X-ray diffraction
Resolution: 1.12 Å
Organism: Human immunodeficiency virus 1
Chains: 3
Atoms: 1,624
Mol. weight: 20.46 kDa
Released: 2 Sept 2008

Explore 3DS4 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3DS4 contains 11 α-helices and 0 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 5 helices, 0 β-strands

Element	Residues	Length
α-helix	150-152	3
α-helix	161-174	14
α-helix	179-192	14
α-helix	196-205	10
α-helix	211-218	8

Chain B: 5 helices, 0 β-strands

Element	Residues	Length
α-helix	161-174	14
α-helix	179-187	9
α-helix	189-192	4
α-helix	196-205	10
α-helix	211-218	8

Chain T: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	3-10	8

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
HIV-1 capsid protein	A, B	protein	86	Human immunodeficiency virus 1	P12497
Peptide inhibitor of capsid assembly	T	protein	12

Sequence of entity 1 (A, B), FASTA

>3DS4_1 HIV-1 CAPSID PROTEIN (chains A, B)
SPTSILDIRQGPKEPFRDYVDRFYKTLRAEQASQEVKNWMTETLLVQNANPDCKTILKAL
GPGATSEEMMTACQGVGGPGHKARVL

Sequence of entity 2 (T), FASTA

>3DS4_2 Peptide inhibitor of capsid assembly (chains T)
ITFEDLLDYYGP

Primary citation

Residues in the HIV-1 Capsid Assembly Inhibitor Binding Site Are Essential for Maintaining the Assembly-competent Quaternary Structure of the Capsid Protein. Bartonova, V., Igonet, S., Sticht, J. et al. J Biol Chem (2008) 283:32024-32033. DOI 10.1074/jbc.M804230200 · PubMed

Other PDB entries of the same protein (UniProt P12497), best resolution first:

3DS2 1.2 Å, HIV-1 capsid C-terminal domain mutant (Y169A)
6T6E 1.3 Å, Crystal Structure of the C-terminal domain of the HIV-1 Integrase (PNL4-3)
2XDE 1.4 Å, Crystal structure of the complex of PF-3450074 with an engineered HIV capsid N terminal…
3L3U 1.4 Å, Crystal structure of the HIV-1 integrase core domain to 1.4A
2PWO 1.45 Å, Crystal Structure of HIV-1 CA146 A92E Psuedo Cell
3WNF 1.45 Å, Cyclic hexapeptide CKIDNC in complex with HIV-1 integrase
6OYD 1.46 Å, X-ray crystal structure of wild type HIV-1 protease in complex with GRL-004
6MCR 1.48 Å, X-ray crystal structure of wild type HIV-1 protease in complex with GRL-001
2PXR 1.5 Å, Crystal Structure of HIV-1 CA146 in the Presence of CAP-1
3WNH 1.5 Å, Cyclic hexapeptide PKZDNv in complex with HIV-1 integrase
4NX4 1.5 Å, Re-refinement of CAP-1 HIV-CA complex
6MCS 1.52 Å, X-ray crystal structure of wild type HIV-1 protease in complex with GRL-003

Browse structure collections

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