ALK-5 kinase complex with GW857175. Determined by X-ray diffraction at 1.8 Å resolution. Released 21 Apr 2009.
Explore 3GXL in 3D Show helices and sheets RCSB PDB PDBe
3GXL contains 16 α-helices and 16 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 2-4 | 3 | |
| β-strand | 6-13 | 8 | 1 |
| β-strand | 18-23 | 6 | 1 |
| β-strand | 29-34 | 6 | 1 |
| α-helix | 36-38 | 3 | |
| α-helix | 39-49 | 11 | |
| β-strand | 59 | 1 | 2 |
| β-strand | 62-69 | 8 | 1 |
| β-strand | 74-80 | 7 | 1 |
| β-strand | 87 | 1 | 2 |
| α-helix | 88-94 | 7 | |
| β-strand | 97 | 1 | 3 |
| α-helix | 99-117 | 19 | |
| β-strand | 120 | 1 | 4 |
| β-strand | 126 | 1 | 4 |
| β-strand | 128-130 | 3 | 5 |
| α-helix | 136-138 | 3 | |
| β-strand | 139-141 | 3 | 2 |
| β-strand | 147-149 | 3 | 2 |
| β-strand | 156-159 | 4 | 5 |
| β-strand | 164-165 | 2 | 5 |
| α-helix | 176-178 | 3 | |
| α-helix | 181-184 | 4 | |
| α-helix | 193-213 | 21 | |
| β-strand | 215 | 1 | 3 |
| α-helix | 222-224 | 3 | |
| α-helix | 238-242 | 5 | |
| α-helix | 243-247 | 5 | |
| α-helix | 262-272 | 11 | |
| α-helix | 279-281 | 3 | |
| α-helix | 283-284 | 2 | |
| α-helix | 285-297 | 13 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| TGF-beta receptor type-1 | A | protein | 303 | Homo sapiens | P36897 (AlphaFold model) |
>3GXL_1 TGF-beta receptor type-1 (chains A) IARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENIL GFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEI VGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMA PEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEE MRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEG IKM
| ID | Name | Formula | Copies |
|---|---|---|---|
| QIG | N-1H-indazol-5-yl-2-(6-methylpyridin-2-yl)quinazolin-4-amine | C21 H16 N6 | 1 |
Design of novel quinazoline derivatives and related analogues as potent and selective ALK5 inhibitors. Gellibert, F., Fouchet, M.-H., Nguyen, V.-L. et al. Bioorg Med Chem Lett (2009) 19:2277-2281. DOI 10.1016/j.bmcl.2009.02.087 · PubMed
Other PDB entries of the same protein (UniProt P36897 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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