3L6Y: P120 catenin

Crystal structure of p120 catenin in complex with E-cadherin. Determined by X-ray diffraction at 3.0 Å resolution. Released 21 Apr 2010.

Method
X-ray diffraction
Resolution
3.0 Å
Organism
Homo sapiens
Chains
6
Atoms
9,099
Mol. weight
202.11 kDa
Released
21 Apr 2010

Explore 3L6Y in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3L6Y contains 84 α-helices and 0 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 25 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix368-3747
α-helix380-39415
α-helix398-4069
α-helix409-4168
α-helix422-43514
α-helix441-4499
α-helix452-46211
α-helix466-48015
α-helix483-49614
α-helix497-5026
α-helix503-5064
α-helix524-53714
α-helix542-5498
α-helix554-56613
α-helix574-58714
α-helix590-5934
α-helix649-6546
α-helix656-66813
α-helix672-68716
α-helix691-70010
α-helix703-7119
α-helix712-7143
α-helix718-73215
α-helix738-7458
α-helix766-77914
Chains B, D and F: 1 helix, 0 β-strands
ElementResiduesLengthSheet
α-helix771-7733
Chain C: 27 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix364-3674
α-helix368-3747
α-helix380-39415
α-helix398-4069
α-helix409-4168
α-helix422-43514
α-helix441-4499
α-helix452-46211
α-helix466-48015
α-helix483-49614
α-helix497-5026
α-helix503-5064
α-helix524-53714
α-helix542-5498
α-helix554-56613
α-helix574-58714
α-helix590-5934
α-helix649-6546
α-helix656-66813
α-helix672-68716
α-helix691-70010
α-helix703-7119
α-helix712-7143
α-helix718-73215
α-helix738-75013
α-helix766-77914
α-helix810-82213
Chain E: 29 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix364-3674
α-helix368-3747
α-helix380-39415
α-helix398-4069
α-helix409-4168
α-helix422-43514
α-helix441-4499
α-helix452-46211
α-helix466-48015
α-helix483-49614
α-helix497-5026
α-helix503-5064
α-helix524-53714
α-helix542-5498
α-helix554-56613
α-helix574-58714
α-helix590-5934
α-helix649-6546
α-helix656-66813
α-helix672-68716
α-helix691-70010
α-helix703-7119
α-helix712-7143
α-helix718-73114
α-helix732-7343
α-helix738-75215
α-helix766-77914
α-helix796-8038
α-helix810-82314

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Catenin delta-1A, C, Eprotein584Homo sapiensO60716 (AlphaFold model)
E-cadherinB, D, Fprotein18P12830 (AlphaFold model)
Sequence of entity 1 (A, C, E), FASTA
>3L6Y_1 Catenin delta-1 (chains A, C, E)
GSPEFMIGEEVPSDQYYWAPLAQHERGSLASLDSLRKGGPPPPNWRQPELPEVIAMLGFR
LDAVKSNAAAYLQHLCYRNDKVKTDVRKLKGIPVLVGLLDHPKKEVHLGACGALKNISFG
RDQDNKIAIKNCDGVPALVRLLRKARDMDLTEVITGTLWNLSSHDSIKMEIVDHALHALT
DEVIIPHSGWEREPNEDCKPRHIEWESVLTNTAGCLRNVSSERSEARRKLRECDGLVDAL
IFIVQAEIGQKDSDSKLVENCVCLLRNLSYQVHREIPQAERYQEAAPNVANNTGTSPARG
YELLFQPEVVRIYISLLKESKTPAILEASAGAIQNLCAGRWTYGRYIRSALRQEKALSAI
ADLLTNEHERVVKAASGALRNLAVDARNKELIGKHAIPNLVKNLPGGQQNSSWNFSEDTV
ISILNTINEVIAENLEAAKKLRETQGIEKLVLINKSGNRSEKEVRAAALVLQTIWGYKEL
RKPLEKEGWKKSDFQVNLNNASRSQSSHSYDDSTLPLIDRNQKSDKKPDREEIQMSNMGS
NTKSLDNNYSTPNERGDHNRTLDRSGDLGDMEPLKGTTPLMQKI
Sequence of entity 2 (B, D, F), FASTA
>3L6Y_2 E-cadherin (chains B, D, F)
DEEGGGEEDQDFDLSQLH

Primary citation

Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion. Ishiyama, N., Lee, S.H., Liu, S. et al. Cell (2010) 141:117-128. DOI 10.1016/j.cell.2010.01.017 · PubMed

Other PDB entries of the same protein (UniProt O60716 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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