3N7L: Neurotoxin

Name: PDB 3N7L: Crystal structure of botulinum neurotoxin serotype D/C VPI 5993 binding domain
Published: 2010-09-08
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: toxin

Crystal structure of botulinum neurotoxin serotype D/C VPI 5993 binding domain. Determined by X-ray diffraction at 2.0 Å resolution. Released 8 Sept 2010.

Method: X-ray diffraction
Resolution: 2.0 Å
Organism: Clostridium botulinum
Chains: 1
Atoms: 3,632
Mol. weight: 49.88 kDa
Released: 8 Sept 2010

Explore 3N7L in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3N7L contains 10 α-helices and 36 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 10 helices, 36 β-strands

Element	Residues	Length	Sheet
α-helix	865-867	3
β-strand	868-875	8	1
β-strand	878-881	4	1
β-strand	888-892	5	2
β-strand	894	1	3
β-strand	896-897	2	1
α-helix	898	1
β-strand	905-908	4	1
β-strand	914	1	3
β-strand	916-920	5	2
α-helix	923-927	5
β-strand	933-943	11	1
β-strand	952-958	7	2
β-strand	963-969	7	2
β-strand	972-980	9	2
β-strand	983-990	8	2
α-helix	993-995	3
β-strand	1004-1011	8	1
β-strand	1015-1020	6	1
β-strand	1023-1029	7	1
β-strand	1041-1048	8	2
α-helix	1049	1
β-strand	1063-1072	10	1
α-helix	1078-1087	10
β-strand	1093	1	4
β-strand	1095	1	5
β-strand	1101	1	5
α-helix	1102	1
β-strand	1103	1	6
β-strand	1107-1112	6	7
β-strand	1118-1123	6	7
β-strand	1126-1131	6	7
β-strand	1144-1150	7	7
β-strand	1157	1	6
β-strand	1159	1	4
β-strand	1163-1169	7	7
β-strand	1174-1179	6	7
β-strand	1190-1196	7	7
α-helix	1200-1206	7
β-strand	1209-1215	7	7
β-strand	1220-1227	8	7
β-strand	1234-1245	12	7
β-strand	1255-1263	9	7
α-helix	1270-1272	3
α-helix	1274-1276	3
β-strand	1278-1282	5	7

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Neurotoxin	A	protein	424	Clostridium botulinum	Q9LBR1

Sequence of entity 1 (A), FASTA

>3N7L_1 Neurotoxin (chains A)
NSINDSKILSLQNKKNTLMDTSGYNAEVRVEGNVQLNPIFPFDFKLGSSGDDRGKVIVTQ
NENIVYNAMYESFSISFWIRINKWVSNLPGYTIIDSVKNNSGWSIGIISNFLVFTLKQNE
NSEQDINFSYDISKNAAGYNKWFFVTITTNMMGNMMIYINGKLIDTIKVKELTGINFSKT
ITFQMNKIPNTGLITSDSDNINMWIRDFYIFAKELDDKDINILFNSLQYTNVVKDYWGND
LRYDKEYYMINVNYMNRYMSKKGNGIVFNTRKNNNDFNEGYKIIIKRIRGNTNDTRVRGE
NVLYFNTTIDNKQYSLGMYKPSRNLGTDLVPLGALDQPMDEIRKYGSFIIQPCNTFDYYA
SQLFLSSNATTNRLGILSIGSYSFKLGDDYWFNHEYLIPVIKIEHYASLLESTSTHWVFV
PASE

Primary citation

Identification of a Unique Ganglioside Binding Loop within Botulinum Neurotoxins C and D-SA . Karalewitz, A.P., Kroken, A.R., Fu, Z. et al. Biochemistry (2010) 49:8117-8126. DOI 10.1021/bi100865f · PubMed

Other PDB entries of the same protein (UniProt Q9LBR1), best resolution first:

4ISR 2.59 Å, Binding domain of Botulinum neurotoxin DC in complex with rat synaptotagmin II
3N7M 2.6 Å, Crystal structure of W1252A mutant of HCR D/C VPI 5995
4ISQ 2.65 Å, Binding domain of Botulinum neurotoxin DC in complex with human synaptotagmin I
4FVV 2.7 Å, Crystal structure of HCR/D-Sa-GBL1/C
3AZW 2.99 Å, Crystal structure of the receptor binding domain
3AZV 3.1 Å, Crystal structure of the receptor binding domain

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