Crystal structure of (73-244)RIa:C holoenzyme of cAMP-dependent Protein kinase. Determined by X-ray diffraction at 3.3 Å resolution. Released 2 Feb 2011.
Explore 3PVB in 3D Show helices and sheets RCSB PDB PDBe
3PVB contains 23 α-helices and 28 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 11-30 | 20 | |
| β-strand | 43-44 | 2 | 1 |
| β-strand | 48-51 | 4 | 2 |
| β-strand | 56-58 | 3 | 2 |
| β-strand | 61-62 | 2 | 1 |
| β-strand | 68 | 1 | 1 |
| β-strand | 69-75 | 7 | 2 |
| α-helix | 76-81 | 6 | |
| α-helix | 85-97 | 13 | |
| β-strand | 106-111 | 6 | 2 |
| β-strand | 115-121 | 7 | 2 |
| β-strand | 127 | 1 | 3 |
| α-helix | 130-133 | 4 | |
| α-helix | 140-158 | 19 | |
| β-strand | 163 | 1 | 4 |
| α-helix | 169-171 | 3 | |
| β-strand | 172 | 1 | 5 |
| β-strand | 173 | 1 | 3 |
| β-strand | 182 | 1 | 5 |
| β-strand | 189 | 1 | 4 |
| β-strand | 195 | 1 | 6 |
| β-strand | 199-200 | 2 | 7 |
| α-helix | 202-204 | 3 | |
| α-helix | 207-211 | 5 | |
| β-strand | 215 | 1 | 6 |
| α-helix | 218-231 | 14 | |
| α-helix | 243-252 | 10 | |
| α-helix | 263-272 | 10 | |
| α-helix | 277-279 | 3 | |
| α-helix | 289-292 | 4 | |
| α-helix | 295-297 | 3 | |
| α-helix | 302-307 | 6 | |
| α-helix | 328-329 | 2 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 92-94 | 3 | |
| β-strand | 98-99 | 2 | 7 |
| α-helix | 105-108 | 4 | |
| α-helix | 120-129 | 10 | |
| α-helix | 141-144 | 4 | |
| α-helix | 146-150 | 5 | |
| β-strand | 152-156 | 5 | 8 |
| β-strand | 163 | 1 | 9 |
| β-strand | 168 | 1 | 10 |
| β-strand | 171-178 | 8 | 8 |
| β-strand | 180-183 | 4 | 9 |
| β-strand | 188-192 | 5 | 9 |
| β-strand | 197-198 | 2 | 8 |
| α-helix | 202-205 | 4 | |
| β-strand | 208 | 1 | 10 |
| β-strand | 212-214 | 3 | 9 |
| β-strand | 219-225 | 7 | 8 |
| α-helix | 226-238 | 13 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| cAMP-dependent protein kinase catalytic subunit alpha | A | protein | 345 | Mus musculus | P05132 (AlphaFold model) |
| cAMP-dependent protein kinase type I-alpha regulatory subunit | B | protein | 160 | Bos taurus | P00514 (AlphaFold model) |
>3PVB_1 cAMP-dependent protein kinase catalytic subunit alpha (chains A) AKKGSEQESVKEFLAKAKEDFLKKWETPSQNTAQLDQFDRIKTLGTGSFGRVMLVKHKES GNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVAG GEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDF GFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQ IYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAI YQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFTEF
>3PVB_2 cAMP-dependent protein kinase type I-alpha regulatory subunit (chains B) PPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNE RSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELAL IYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKM
| ID | Name | Formula | Copies |
|---|---|---|---|
| ANP | Phosphoaminophosphonic acid-adenylate ester | C10 H17 N6 O12 P3 | 1 |
| MN | Manganese (II) ion | Mn | 2 |
Water and common crystallization additives (GOL) are not listed.
Crystal structure of (73-244)RIa:C holoenzyme of cAMP-dependent Protein kinase. Boettcher, A.J., Wu, J., Kim, C. et al. Structure (2011) 19:265-276. DOI 10.1016/j.str.2010.12.005 · PubMed
Other PDB entries of the same protein (UniProt P05132 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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