3QEK: NMDA glutamate receptor subunit

Crystal structure of amino terminal domain of the NMDA receptor subunit GluN1. Determined by X-ray diffraction at 2.0 Å resolution. Released 15 Jun 2011.

Method
X-ray diffraction
Resolution
2.0 Å
Organism
Xenopus laevis
Chains
2
Atoms
5,994
Mol. weight
88.43 kDa
Ligands
NAG
Released
15 Jun 2011

Explore 3QEK in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3QEK contains 44 α-helices and 34 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 23 helices, 17 β-strands

ElementResiduesLengthSheet
α-helix241
β-strand25-3391
α-helix36-5217
β-strand58-6691
α-helix67-682
α-helix71-777
α-helix78-825
α-helix83-853
β-strand87-9261
α-helix105-1128
β-strand118-12031
α-helix126-1294
β-strand137-13931
α-helix144-1463
α-helix147-15711
β-strand162-16872
α-helix171-18414
α-helix207-2104
β-strand211-21882
α-helix226-2338
β-strand239-24352
α-helix246-25813
β-strand267-26932
α-helix273-2753
α-helix277-2804
α-helix283-2842
β-strand288-29252
α-helix298-31720
α-helix324-3263
α-helix339-3479
β-strand351-35443
β-strand357-35933
β-strand36114
α-helix3661
β-strand36714
α-helix3681
β-strand372-37872
β-strand381-38882
β-strand393-39532
α-helix399-4024
Chain B: 21 helices, 17 β-strands
ElementResiduesLengthSheet
β-strand26-3385
α-helix36-5217
β-strand59-6685
α-helix67-682
α-helix71-777
α-helix78-825
α-helix83-853
β-strand87-9265
α-helix105-1128
β-strand118-12035
α-helix126-1294
β-strand137-13935
α-helix144-1474
α-helix148-15710
β-strand162-16876
α-helix171-19424
β-strand211-21886
α-helix226-2338
β-strand239-24356
α-helix246-25813
β-strand267-27046
α-helix273-2753
α-helix277-2826
α-helix283-2842
β-strand288-29256
α-helix298-31619
α-helix322-3265
α-helix339-3479
β-strand351-35447
β-strand357-35937
β-strand36118
α-helix3661
β-strand36718
α-helix3681
β-strand372-37876
β-strand381-38886
β-strand393-39536
α-helix399-4002

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
NMDA glutamate receptor subunitA, Bprotein384Xenopus laevisA0A1L8F5J9 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>3QEK_1 NMDA glutamate receptor subunit (chains A, B)
SDPKIVNIGAVLSTKKHEQIFREAVNQANKRHFTRKIQLQATSVTHRPNAIQMALSVCED
LISSQVYAILVSHPPAPTDHLTPTPISYTAGFYRIPVIGLTTRMSIYSDKSIHLSFLRTV
PPYSHQALVWFEMMRLFNWNHVILIVSDDHEGRAAQKKLETLLEGKESKSKKRNYENLDQ
LSYDNKRGPKADKVLQFEPGTKNLTALLLEAKELEARVIILSASEDDATAVYKSAAMLDM
TGAGYVWLVGEREISGSALRYAPDGIIGLQLINGKNESAHISDAVAVVAQAIHELFEMEN
ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYPDGVTGRIEFNEDGDRKFAQYSIMNLQNRK
LVQVGIFNGSYIIQNDRKIIWPGG

Ligands and cofactors

IDNameFormulaCopies
NAG2-acetamido-2-deoxy-beta-D-glucopyranoseC8 H15 N O64

Water and common crystallization additives (K) are not listed.

Primary citation

Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors. Karakas, E., Simorowski, N., Furukawa, H. Nature (2011) 475:249-253. DOI 10.1038/nature10180 · PubMed

Other PDB entries of the same protein (UniProt A0A1L8F5J9 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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