Crystal structure of unliganded HIV-1 clade A/E strain 93TH057 gp120 core. Determined by X-ray diffraction at 1.9 Å resolution. Released 4 Apr 2012.
Explore 3TGT in 3D Show helices and sheets RCSB PDB PDBe
3TGT contains 15 α-helices and 28 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 45-47 | 3 | 1 |
| β-strand | 53-56 | 4 | 2 |
| α-helix | 65-73 | 9 | |
| β-strand | 75-76 | 2 | 2 |
| α-helix | 77-78 | 2 | |
| β-strand | 83-85 | 3 | 1 |
| β-strand | 91-94 | 4 | 3 |
| α-helix | 99-115 | 17 | |
| β-strand | 120-123 | 4 | 4 |
| β-strand | 199-202 | 4 | 4 |
| β-strand | 215 | 1 | 5 |
| β-strand | 216-218 | 3 | 2 |
| α-helix | 219-220 | 2 | |
| β-strand | 223-228 | 6 | 1 |
| β-strand | 236-239 | 4 | 3 |
| β-strand | 242-245 | 4 | 1 |
| β-strand | 247 | 1 | 2 |
| α-helix | 248-250 | 3 | |
| β-strand | 251 | 1 | 5 |
| β-strand | 256 | 1 | 6 |
| β-strand | 259-261 | 3 | 6 |
| α-helix | 264-266 | 3 | |
| β-strand | 271-273 | 3 | 6 |
| β-strand | 284-298 | 15 | 6 |
| β-strand | 328-334 | 7 | 6 |
| α-helix | 335-352 | 18 | |
| α-helix | 357 | 1 | |
| β-strand | 358-361 | 4 | 6 |
| α-helix | 369-372 | 4 | |
| β-strand | 374-378 | 5 | 6 |
| β-strand | 381-385 | 5 | 6 |
| α-helix | 388-391 | 4 | |
| α-helix | 393-395 | 3 | |
| β-strand | 413-420 | 8 | 6 |
| β-strand | 423-425 | 3 | 4 |
| β-strand | 432-434 | 3 | 4 |
| α-helix | 436-439 | 4 | |
| β-strand | 443-456 | 14 | 6 |
| α-helix | 457 | 1 | |
| α-helix | 460-462 | 3 | |
| β-strand | 465-470 | 6 | 6 |
| α-helix | 475-483 | 9 | |
| β-strand | 486-491 | 6 | 1 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| HIV-1 clade A/E 93TH057 gp120 | A | protein | 353 | Human immunodeficiency virus 1 | Q0ED31 |
>3TGT_1 HIV-1 clade A/E 93TH057 gp120 (chains A) VWKDADTTLFCASDAKAHETEVHNVWATHACVPTDPNPQEIHLENVTENFNMWKNNMVEQ MQEDVISLWDQSLQPCVKLTGGSVIKQACPKISFDPIPIHYCTPAGYVILKCNDKNFNGT GPCKNVSSVQCTHGIKPVVSTQLLLNGSLAEEEIIIRSENLTNNAKTIIVHLNKSVEINC TRPSNGGSGSGGDIRKAYCEINGTKWNKVLKQVTEKLKEHFNNKTIIFQPPSGGDLEITM HHFNCRGEFFYCNTTQLFNNTCIGNETMKGCNGTITLPCKIKQIINMWQGTGQAMYAPPI DGKINCVSNITGILLTRDGGANNTSNETFRPGGGNIKDNWRSELYKYKVVQIE
| ID | Name | Formula | Copies |
|---|---|---|---|
| NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose | C8 H15 N O6 | 10 |
Water and common crystallization additives (EPE) are not listed.
Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops. Kwon, Y.D., Finzi, A., Wu, X. et al. Proc Natl Acad Sci U S A (2012) 109:5663-5668. DOI 10.1073/pnas.1112391109 · PubMed
Other PDB entries of the same protein (UniProt Q0ED31), best resolution first:
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