TGF-beta Receptor type 1 in complex with SB431542. Determined by X-ray diffraction at 1.7 Å resolution. Released 23 May 2012.
Explore 3TZM in 3D Show helices and sheets RCSB PDB PDBe
3TZM contains 17 α-helices and 19 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 202-204 | 3 | |
| β-strand | 205-213 | 9 | 1 |
| β-strand | 218-224 | 7 | 1 |
| β-strand | 227-234 | 8 | 1 |
| α-helix | 236-238 | 3 | |
| α-helix | 239-249 | 11 | |
| β-strand | 259 | 1 | 2 |
| β-strand | 262-269 | 8 | 1 |
| β-strand | 274-281 | 8 | 1 |
| β-strand | 287 | 1 | 2 |
| α-helix | 288-294 | 7 | |
| β-strand | 297 | 1 | 3 |
| α-helix | 299-317 | 19 | |
| β-strand | 320 | 1 | 4 |
| β-strand | 326 | 1 | 4 |
| β-strand | 329-330 | 2 | 5 |
| α-helix | 336-338 | 3 | |
| β-strand | 339-341 | 3 | 2 |
| β-strand | 347-349 | 3 | 2 |
| β-strand | 356-357 | 2 | 5 |
| β-strand | 358-359 | 2 | 6 |
| β-strand | 364-365 | 2 | 6 |
| α-helix | 376-378 | 3 | |
| α-helix | 381-384 | 4 | |
| α-helix | 393-413 | 21 | |
| β-strand | 415 | 1 | 3 |
| β-strand | 417 | 1 | 7 |
| β-strand | 420 | 1 | 7 |
| α-helix | 422-424 | 3 | |
| α-helix | 438-442 | 5 | |
| α-helix | 443-447 | 5 | |
| α-helix | 456-460 | 5 | |
| α-helix | 462-474 | 13 | |
| α-helix | 479-481 | 3 | |
| α-helix | 483-484 | 2 | |
| α-helix | 485-495 | 11 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| TGF-beta receptor type-1 | A | protein | 309 | Homo sapiens | P36897 (AlphaFold model) |
>3TZM_1 TGF-beta receptor type-1 (chains A) GAMGSTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVML RHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLA HLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVG TKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPS DPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQ LSQQEGIKM
| ID | Name | Formula | Copies |
|---|---|---|---|
| 085 | 4-[5-(1,3-benzodioxol-5-yl)-4-(pyridin-2-yl)-1H-imidazol-2-yl]benzamide | C22 H16 N4 O3 | 1 |
Structural Basis for Specificity of TGFbeta Family Receptor Small Molecule Inhibitors. Ogunjimi, A.A., Zeqiraj, E., Ceccarelli, D.F. et al. Cell Signal (2012) 24:476-483. DOI 10.1016/j.cellsig.2011.09.027 · PubMed
Other PDB entries of the same protein (UniProt P36897 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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