Crystal Structure of the Human Fyn SH3 domain in complex with a peptide from the Hepatitis C virus NS5A-protein. Determined by X-ray diffraction at 1.5 Å resolution. Released 25 Jul 2012.
Explore 3UA7 in 3D Show helices and sheets RCSB PDB PDBe
3UA7 contains 10 α-helices and 32 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 87-89 | 3 | 1 |
| β-strand | 93 | 1 | 2 |
| β-strand | 100 | 1 | 1 |
| α-helix | 101-102 | 2 | |
| β-strand | 103 | 1 | 2 |
| β-strand | 108-113 | 6 | 1 |
| β-strand | 119-124 | 6 | 1 |
| β-strand | 130-134 | 5 | 1 |
| α-helix | 135-137 | 3 | |
| β-strand | 138-140 | 3 | 1 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 87-89 | 3 | 3 |
| β-strand | 93 | 1 | 4 |
| β-strand | 100 | 1 | 3 |
| β-strand | 103 | 1 | 4 |
| β-strand | 108-113 | 6 | 3 |
| β-strand | 119-124 | 6 | 3 |
| β-strand | 130-134 | 5 | 3 |
| α-helix | 135-137 | 3 | |
| β-strand | 138-140 | 3 | 3 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 84-86 | 3 | |
| β-strand | 87-89 | 3 | 5 |
| β-strand | 93 | 1 | 6 |
| β-strand | 100 | 1 | 5 |
| α-helix | 101-102 | 2 | |
| β-strand | 103 | 1 | 6 |
| β-strand | 108-113 | 6 | 5 |
| β-strand | 119-124 | 6 | 5 |
| β-strand | 130-134 | 5 | 5 |
| α-helix | 135-137 | 3 | |
| β-strand | 138-140 | 3 | 5 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 86-89 | 4 | 7 |
| β-strand | 93 | 1 | 8 |
| β-strand | 100 | 1 | 7 |
| α-helix | 101-102 | 2 | |
| β-strand | 103 | 1 | 8 |
| β-strand | 108-113 | 6 | 7 |
| β-strand | 119-124 | 6 | 7 |
| β-strand | 130-134 | 5 | 7 |
| α-helix | 135-137 | 3 | |
| β-strand | 138-140 | 3 | 7 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 2-7 | 6 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Tyrosine-protein kinase Fyn | A, B, C, D | protein | 64 | Homo sapiens | P06241 (AlphaFold model) |
| Non-structural protein 5A | E, F | protein | 12 | Hepatitis C virus | P26663 |
>3UA7_1 Tyrosine-protein kinase Fyn (chains A, B, C, D) MGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVA PVDS
>3UA7_2 Non-structural protein 5A (chains E, F) XAPPIPPPRRKR
| ID | Name | Formula | Copies |
|---|---|---|---|
| ZN | Zinc ion | Zn | 2 |
Water and common crystallization additives (FMT, NA, CL, GOL) are not listed.
The promiscuous binding of the Fyn SH3 domain to a peptide from the NS5A protein. Martin-Garcia, J.M., Luque, I., Ruiz-Sanz, J. et al. Acta Crystallogr D Biol Crystallogr (2012) 68:1030-1040. DOI 10.1107/S0907444912019798 · PubMed
Other PDB entries of the same protein (UniProt P06241 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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