3VYC: Unliganded Saccharomyces cerevisiae CRM1

Crystal structure of unliganded Saccharomyces cerevisiae CRM1 (Xpo1p). Determined by X-ray diffraction at 2.1 Å resolution. Released 28 Nov 2012.

Method

X-ray diffraction

Resolution

2.1 Å

Organism

Saccharomyces cerevisiae

Chains

1

Atoms

8,180

Mol. weight

118.76 kDa

Released

28 Nov 2012

Explore 3VYC in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3VYC contains 65 α-helices and 2 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 65 helices, 2 β-strands

Molecules and chains

>3VYC_1 Exportin-1 (chains A)
MEGILDFSNDLDIALLDQVVSTFYQGSGVQQKQAQEILTKFQDNPDAWQKADQILQFSTN
PQSKFIALSILDKLITRKWKLLPNDHRIGIRNFVVGMIISMCQDDEVFKTQKNLINKSDL
TLVQILKQEWPQNWPEFIPELIGSSSSSVNVCENNMIVLKLLSEEVFDFSAEQMTQAKAL
HLKNSMSKEFEQIFKLCFQVLEQGSSSSLIVATLESLLRYLHWIPYRYIYETNILELLST
KFMTSPDTRAITLKCLTEVSNLKIPQDNDLIKRQTVLFFQNTLQQIATSVMPVTADLKAT
YANANGNDQSFLQDLAMFLTTYLARNRALLESDESLRELLLNAHQYLIQLSKIEERELFK
TTLDYWHNLVADLFYEPLKKHIYEEICSQLRLVIIENMVRPEEVLVVENDEGEIVREFVK
ESDTIQLYKSEREVLVYLTHLNVIDTEEIMISKLARQIDGSEWSWHNINTLSWAIGSISG
TMSEDTEKRFVVTVIKDLLDLTVKKRGKDNKAVVASDIMYVVGQYPRFLKAHWNFLRTVI
LKLFEFMHETHEGVQDMACDTFIKIVQKCKYHFVIQQPRESEPFIQTIIRDIQKTTADLQ
PQQVHTFYKACGIIISEERSVAERNRLLSDLMQLPNMAWDTIVEQSTANPTLLLDSETVK
IIANIIKTNVAVCTSMGADFYPQLGHIYYNMLQLYRAVSSMISAQVAAEGLIATKTPKVR
GLRTIKKEILKLVETYISKARNLDDVVKVLVEPLLNAVLEDYMNNVPDARDAEVLNCMTT
VVEKVGHMIPQGVILILQSVFECTLDMINKDFTEYPEHRVEFYKLLKVINEKSFAAFLEL
PPAAFKLFVDAICWAFKHNNRDVEVNGLQIALDLVKNIERMGNVPFANEFHKNYFFIFVS
ETFFVLTDSDHKSGFSKQALLLMKLISLVYDNKTSNQVYLSQYLANMLSNAFPHLTSEQI
ASFLSALTKQYKDLVVFKGTLRDFLVQIKEVGGDPTDYLFAEDKENALMEQNRLEREKAA
KIGGLLKPSELDD

Primary citation

A 2.1- angstrom -resolution crystal structure of unliganded CRM1 reveals the mechanism of autoinhibition. Saito, N., Matsuura, Y. J Mol Biol (2013) 425:350-364. DOI 10.1016/j.jmb.2012.11.014 · PubMed

Related structures

Other PDB entries of the same protein (UniProt P30822 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 4HAT 1.78 Å, Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1-Ran-RanBP1
• 4HB2 1.8 Å, Crystal structure of CRM1-Ran-RanBP1
• 4WVF 1.8 Å, Crystal structure of KPT276 in complex with CRM1-Ran-RanBP1
• 7CND 1.8 Å, NCI-1 in complex with CRM1-Ran-RanBP1
• 4HAW 1.9 Å, Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(K548A)-Ran-RanBP1
• 4HAZ 1.9 Å, Crystal structure of CRM1 inhibitor Leptomycin B in complex with…
• 6XJR 1.94 Å, Crystal Structure of KPT-185 bound to CRM1 (E582K, 537-DLTVK-541 to GLCEQ)
• 6XJS 1.94 Å, Crystal Structure of KPT-330 bound to CRM1 (E582K, 537-DLTVK-541 to GLCEQ)
• 7L5E 1.94 Å, Crystal Structure of KPT-330 bound to CRM1 (537-DLTVK-541 to GLCEQ)
• 3M1I 2.0 Å, Crystal structure of yeast CRM1 (Xpo1p) in complex with yeast RanBP1 (Yrb1p) and yeast…
• 4HAU 2.0 Å, Crystal structure of CRM1 inhibitor Ratjadone A in complex with CRM1-Ran-RanBP1
• 4HAV 2.0 Å, Crystal structure of CRM1 inhibitor Anguinomycin A in complex with CRM1-Ran-RanBP1

Browse structure collections

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