3WOQ: DAP BII hexapeptide complex III

Crystal structure of the DAP BII hexapeptide complex III. Determined by X-ray diffraction at 1.82 Å resolution. Released 3 Sept 2014.

Method

X-ray diffraction

Resolution

1.82 Å

Organisms

Pseudoxanthomonas mexicana, Homo sapiens

Chains

4

Atoms

11,667

Mol. weight

155.16 kDa

Ligands

ZN

Released

3 Sept 2014

Explore 3WOQ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

3WOQ contains 78 α-helices and 48 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 40 helices, 24 β-strands

Molecules and chains

>3WOQ_1 dipeptidyl aminopeptidase BII (chains A, B)
GEGMWVPQQLPEIAGPLKKAGLKLSPQQISDLTGDPMGAVVALGGCTASFVSPNGLVVTN
HACAYGAIQLNSTAENNLIKNGFNAPTTADEVSAGPNARVFVLDEITDVTKDAKAAIAAA
GDDALARTKALEAFEKKLIADCEAEAGFRCRLYSFSGGNTYRLFKNLEIKDVRLAYAPPG
SVGKFGGDIDNWMWPRHTGAFAFYRAYVGKDGKPAAFSKDNVPYQPKHWLKFADQPLGAG
DFVMVAGYPGSTNRYALAAEFDNTAQWTYPTIARHYKNQIAMVEAAGKQNADIQVKYAAT
MAGWNNTSKNYDGQLEGFKRIDAAGQKLREEAAVLGWLKGQGAKGQPALDAHAKLLDLLE
QSKATRDRDLTLALFNNTAMLGSATQLYRLSIEREKPNAERESGYQERDLPAIEGGLKQL
ERRYVAAMDRQLQEYWLNEYIKLPADQRVAAVDAWLGGNDAAAVKRALDRLAGTKLGSTE
ERLKWFAADRKAFEASNDPAIQYAVAVMPTLLKLEQERKTRAGENLAARPVYLQALADYK
KSQGEFVYPDANLSLRITFGNVMGYAPKDGMEYTPFTTLEGVVAKETGQDPFDSPKALLD
AVAAKRYGGLEDKRIGSVPVNYLSDLDITGGNAGSPVLDAHGKLVGLAFDGNWESVSSNW
VFDPKMTRMIAVDGRYLRWIMQEVYPAPQLLKEMNVGK

>3WOQ_2 Angiotensin IV (chains C, D)
VYIHPF

Ligands and cofactors

Water and common crystallization additives (GOL) are not listed.

Primary citation

S46 peptidases are the first exopeptidases to be members of clan PA. Sakamoto, Y., Suzuki, Y., Iizuka, I. et al. Sci Rep (2014) 4:4977-4977. DOI 10.1038/srep04977 · PubMed

Related structures

Other PDB entries of the same protein (UniProt V5YM14 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 3WOL 1.74 Å, Crystal structure of the DAP BII dipeptide complex I
• 3WON 1.75 Å, Crystal structure of the DAP BII dipeptide complex III
• 3WOO 1.8 Å, Crystal structure of the DAP BII hexapeptide complex I
• 3WOM 1.86 Å, Crystal structure of the DAP BII dipeptide complex II
• 3WOK 1.95 Å, Crystal structure of the DAP BII (Space)
• 3WOP 1.95 Å, Crystal structure of the DAP BII hexapeptide complex II
• 3WOI 2.1 Å, Crystal structure of the DAP BII (S657A)
• 3WOR 2.1 Å, Crystal structure of the DAP BII octapeptide complex
• 4Y06 2.18 Å, Crystal structure of the DAP BII (G675R) dipeptide complex
• 3WOJ 2.2 Å, Crystal structure of the DAP BII

Browse structure collections

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