Crystal structure of the human KLHL11-Cul3 complex at 2.8A resolution. Determined by X-ray diffraction at 2.8 Å resolution. Released 9 May 2012.
Explore 4AP2 in 3D Show helices and sheets RCSB PDB PDBe
4AP2 contains 45 α-helices and 3 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 76-89 | 14 | |
| β-strand | 96-99 | 4 | 1 |
| β-strand | 107-110 | 4 | 1 |
| α-helix | 112-118 | 7 | |
| α-helix | 122-125 | 4 | |
| α-helix | 132-135 | 4 | |
| β-strand | 137-139 | 3 | 1 |
| α-helix | 151-163 | 13 | |
| α-helix | 173-182 | 10 | |
| α-helix | 186-198 | 13 | |
| α-helix | 205-214 | 10 | |
| α-helix | 218-228 | 11 | |
| α-helix | 232-235 | 4 | |
| α-helix | 239-243 | 5 | |
| α-helix | 246-254 | 9 | |
| α-helix | 263-276 | 14 | |
| α-helix | 278-281 | 4 | |
| α-helix | 285-291 | 7 | |
| α-helix | 299-301 | 3 | |
| α-helix | 302-306 | 5 | |
| α-helix | 310-314 | 5 | |
| α-helix | 316-335 | 20 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 24-26 | 3 | |
| α-helix | 27-45 | 19 | |
| α-helix | 54-66 | 13 | |
| α-helix | 70-84 | 15 | |
| α-helix | 85-89 | 5 | |
| α-helix | 90-94 | 5 | |
| α-helix | 101-122 | 22 | |
| α-helix | 124-128 | 5 | |
| α-helix | 130-133 | 4 | |
| α-helix | 139-147 | 9 | |
| α-helix | 148-152 | 5 | |
| α-helix | 156-173 | 18 | |
| α-helix | 180-192 | 13 | |
| α-helix | 199-201 | 3 | |
| α-helix | 202-206 | 5 | |
| α-helix | 207-227 | 21 | |
| α-helix | 230-250 | 21 | |
| α-helix | 254-256 | 3 | |
| α-helix | 257-268 | 12 | |
| α-helix | 270-272 | 3 | |
| α-helix | 273-277 | 5 | |
| α-helix | 284-289 | 6 | |
| α-helix | 293-303 | 11 | |
| α-helix | 309-330 | 22 | |
| α-helix | 339-358 | 20 | |
| α-helix | 364-380 | 17 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Kelch-like protein 11 | A | protein | 297 | HOMO SAPIENS | Q9NVR0 (AlphaFold model) |
| Cullin-3 | B | protein | 410 | HOMO SAPIENS | Q13618 (AlphaFold model) |
>4AP2_1 KELCH-LIKE PROTEIN 11 (chains A) MHHHHHHSSGVDLGTENLYFQSMEAEDFECSSHCSELSWRQNEQRRQGLFCDITLCFGGA GGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWSSEPGPEPDTVEAVIEYMYT GRIRVSTGSVHEVLELADRFLLIRLKEFCGEFLKKKLHLSNCVAIHSLAHMYTLSQLALK AADMIRRNFHKVIQDEEFYTLPFHLIRDWLSDLEITVDSEEVLFETVLKWVQRNAEERER YFEELFKLLRLSQMKPTYLTRHVKPERLVANNEVCVKLVADAVERHALRAENIQSGT
>4AP2_2 CULLIN-3 (chains B) MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRN AYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIR DILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDR GAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEAR INEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMY KLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYRQGLDDLKSRFDRFLLESF NNDRLFKQTIAGDFEYFLNLNSRSPEYLAENLYFQSHHHHHHDYKDDDDK
Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases. Canning, P., Cooper, C.D.O., Krojer, T. et al. J Biol Chem (2013) 288:7803. DOI 10.1074/JBC.M112.437996 · PubMed
Other PDB entries of the same protein (UniProt Q9NVR0 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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