4APF: Human KLHL11-Cul3 complex

Crystal structure of the human KLHL11-Cul3 complex at 3.1A resolution. Determined by X-ray diffraction at 3.1 Å resolution. Released 9 May 2012.

Method
X-ray diffraction
Resolution
3.1 Å
Organism
HOMO SAPIENS
Chains
2
Atoms
4,641
Mol. weight
80.25 kDa
Released
9 May 2012

Explore 4APF in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4APF contains 48 α-helices and 3 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 20 helices, 3 β-strands

ElementResiduesLengthSheet
α-helix75-9016
β-strand96-9941
β-strand107-11041
α-helix112-1187
α-helix122-1276
α-helix132-1354
β-strand138-13921
α-helix151-16313
α-helix172-18211
α-helix186-19813
α-helix204-21411
α-helix218-23013
α-helix232-2354
α-helix239-2435
α-helix246-2538
α-helix264-27613
α-helix278-2814
α-helix285-2917
α-helix294-2963
α-helix299-3013
α-helix302-3065
α-helix310-3145
α-helix316-33116
Chain B: 28 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix27-4519
α-helix49-513
α-helix54-6613
α-helix70-8415
α-helix85-906
α-helix91-955
α-helix101-12222
α-helix124-1263
α-helix127-1315
α-helix132-1332
α-helix139-1479
α-helix148-1525
α-helix156-17318
α-helix180-19213
α-helix199-2013
α-helix202-2065
α-helix207-22721
α-helix230-25122
α-helix254-2563
α-helix257-2648
α-helix265-2695
α-helix270-2723
α-helix273-2775
α-helix283-2897
α-helix293-30311
α-helix309-32517
α-helix345-35814
α-helix364-37815

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Kelch-like protein 11Aprotein297HOMO SAPIENSQ9NVR0 (AlphaFold model)
Cullin 3Bprotein388HOMO SAPIENSQ13618 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>4APF_1 KELCH-LIKE PROTEIN 11 (chains A)
MHHHHHHSSGVDLGTENLYFQSMEAEDFECSSHCSELSWRQNEQRRQGLFCDITLCFGGA
GGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWSSEPGPEPDTVEAVIEYMYT
GRIRVSTGSVHEVLELADRFLLIRLKEFCGEFLKKKLHLSNCVAIHSLAHMYTLSQLALK
AADMIRRNFHKVIQDEEFYTLPFHLIRDWLSDLEITVDSEEVLFETVLKWVQRNAEERER
YFEELFKLLRLSQMKPTYLTRHVKPERLVANNEVCVKLVADAVERHALRAENIQSGT
Sequence of entity 2 (B), FASTA
>4APF_2 CULLIN 3 (chains B)
MTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVT
EHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNL
GLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSVYE
EDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVK
VVERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMYKLFSRVPNGLKTMCECMSSYLR
EQGKALVSEEGEGKNPVDYRQGLDDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLNS
RSPEYLAENLYFQSHHHHHHDYKDDDDK

Primary citation

Structural Basis for Cul3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases. Canning, P., Cooper, C.D.O., Krojer, T. et al. J Biol Chem (2013) 288:7803. DOI 10.1074/JBC.M112.437996 · PubMed

Other PDB entries of the same protein (UniProt Q9NVR0 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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