4B8O: RImp_alpha_SV40TAgNLS

rImp_alpha_SV40TAgNLS. Determined by X-ray diffraction at 2.08 Å resolution. Released 9 Jan 2013.

Method: X-ray diffraction
Resolution: 2.08 Å
Organisms: ORYZA SATIVA JAPONICA GROUP, SIMIAN VIRUS 40
Chains: 3
Atoms: 3,559
Mol. weight: 55.4 kDa
Released: 9 Jan 2013

Explore 4B8O in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4B8O contains 33 α-helices and 0 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 32 helices, 0 β-strands

Element	Residues	Length
α-helix	74-82	9
α-helix	86-100	15
α-helix	108-113	6
α-helix	117-124	8
α-helix	130-143	14
α-helix	148-156	9
α-helix	159-166	8
α-helix	172-187	16
α-helix	190-198	9
α-helix	202-207	6
α-helix	215-229	15
α-helix	234-236	3
α-helix	237-240	4
α-helix	243-250	8
α-helix	256-269	14
α-helix	274-282	9
α-helix	286-292	7
α-helix	298-311	14
α-helix	316-323	8
α-helix	327-336	10
α-helix	341-355	15
α-helix	359-368	10
α-helix	371-380	10
α-helix	383-399	17
α-helix	402-410	9
α-helix	414-419	6
α-helix	420-422	3
α-helix	426-450	25
α-helix	456-463	8
α-helix	466-472	7
α-helix	473-475	3
α-helix	479-492	14

Chain B: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	124-126	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Importin subunit alpha-1A	A	protein	490	ORYZA SATIVA JAPONICA GROUP	Q71VM4 (AlphaFold model)
SV40TAGNLS	B, C	protein	11	SIMIAN VIRUS 40	A7XWN5

Sequence of entity 1 (A), FASTA

>4B8O_1 IMPORTIN SUBUNIT ALPHA-1A (chains A)
GSGMKETAAAKFERQHMDSPDLGTDDDDKAMADIGSSLPAMIGGVYSDDNNLQLEATTQF
RKLLSIERSPPIEEVIQSGVVPRFVQFLTREDFPQLQFEAAWALTNIASGTSENTKVVID
HGAVPIFVKLLGSSSDDVREQAVWALGNVAGDSPKCRDLVLANGALLPLLAQLNEHTKLS
MLRNATWTLSNFCRGKPQPSFEQTRPALPALARLIHSNDEEVLTDACWALSYLSDGTNDK
IQAVIEAGVCPRLVELLLHPSPSVLIPALRTVGNIVTGDDAQTQCIIDHQALPCLLSLLT
QNLKKSIKKEACWTISNITAGNKDQIQAVINAGIIGPLVNLLQTAEFDIKKEAAWAISNA
TSGGSHDQIKYLVSEGCIKPLCDLLICPDIRIVTVCLEGLENILKVGETDKTLAAGDVNV
FSQMIDEAEGLEKIENLQSHDNNEIYEKAVKILEAYWMDEEDDTMGATTVAAPQGATFDF
GQGGGAAQFK

Sequence of entity 2 (B, C), FASTA

>4B8O_2 SV40TAGNLS (chains B, C)
GSPPKKKRKVG

Primary citation

Crystal Structure of Rice Importin-Alpha and Structural Basis of its Interaction with Plant-Specific Nuclear Localization Signals. Chang, C.-W., Counago, R.L.M., Williams, S.J. et al. Plant Cell (2012) 24:5074. DOI 10.1105/TPC.112.104422 · PubMed

Other PDB entries of the same protein (UniProt Q71VM4 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4BQK 2.0 Å, rice importin_alpha : VirD2NLS complex
4B8J 2.0 Å, rImp_alpha1a
2YNS 2.1 Å, rImp_alpha_B54NLS
4B8P 2.3 Å, rImp_alpha_A89NLS
4BPL 2.3 Å, rice importin_alpha in complex with nucleoplasmin NLS

Browse structure collections

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