4BER: Phosphocholine transferase ankx

Crystal structure of the Legionella pneumophila FIC domain-containing effector AnkX protein in complex with cytidine monophosphate. Determined by X-ray diffraction at 2.6 Å resolution. Released 24 Apr 2013.

Method
X-ray diffraction
Resolution
2.6 Å
Organism
LEGIONELLA PNEUMOPHILA
Chains
2
Atoms
7,719
Mol. weight
110.9 kDa
Ligands
PO4, C5P
Released
24 Apr 2013

Explore 4BER in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4BER contains 75 α-helices and 24 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 38 helices, 12 β-strands

ElementResiduesLengthSheet
β-strand2-431
α-helix11-166
α-helix19-257
α-helix29-313
α-helix32-354
α-helix39-446
α-helix48-6518
α-helix69-702
α-helix74-8310
α-helix89-924
β-strand106-10942
α-helix111-1133
β-strand11413
α-helix116-1249
α-helix126-1305
β-strand134-13742
β-strand138-13924
β-strand14215
β-strand14415
β-strand146-14724
α-helix157-1593
α-helix160-17415
β-strand181-18442
α-helix190-20617
α-helix211-22717
α-helix235-2362
α-helix237-2437
α-helix245-2506
α-helix253-2564
β-strand26613
α-helix269-29123
α-helix294-2963
α-helix298-3003
α-helix305-31410
α-helix318-3247
α-helix334-34411
α-helix345-3473
α-helix352-3598
α-helix363-3708
α-helix375-3784
α-helix380-3812
β-strand38216
α-helix3831
β-strand39116
α-helix395-4028
α-helix405-4139
α-helix428-4347
α-helix438-44811
α-helix454-4585
α-helix468-4736
Chain B: 37 helices, 12 β-strands
ElementResiduesLengthSheet
β-strand2-431
α-helix11-166
α-helix19-257
α-helix29-313
α-helix32-354
α-helix39-446
α-helix48-6518
α-helix69-702
α-helix74-8310
α-helix92-943
β-strand106-10947
α-helix111-1133
β-strand11418
α-helix116-1249
α-helix126-1305
β-strand134-13747
β-strand138-13929
β-strand142110
β-strand144110
β-strand146-14729
α-helix157-1593
α-helix160-17415
β-strand181-18447
α-helix190-20617
α-helix211-22717
α-helix235-2362
α-helix237-2437
α-helix245-2506
α-helix253-2564
β-strand26618
α-helix269-29123
α-helix294-2963
α-helix298-3003
α-helix305-31410
α-helix318-3247
α-helix334-34411
α-helix352-3598
α-helix363-3708
α-helix375-3784
α-helix380-3812
β-strand382111
α-helix3831
β-strand391111
α-helix395-4028
α-helix405-4139
α-helix428-4347
α-helix438-44811
α-helix454-4585
α-helix468-4725

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Phosphocholine transferase ankxA, Bprotein484LEGIONELLA PNEUMOPHILAQ5ZXN6 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>4BER_1 PHOSPHOCHOLINE TRANSFERASE ANKX (chains A, B)
GVKIMPNLPGLYFLQAYPSEEIWRLFVDGRFWSKENGWRGYESREPGCLNAALESLCSIA
LQVEKSGEEFELSVDLIKRIHKKCGKKVEELQEKNPGELRTDEPVSFGIPAGRASIKGIE
EFLSLVFLTEGGAEFGPGKAGPFGPRFDKNYFKNLNPEQIPDLAKQIYFDMCKYGHSNTN
HFYLAVMKNVDVYLEKITQSYNKEIKTAETLDEKLKIIVKHIRMYEVLHPFRDANGRTFV
NNLLNIPLMQQGLPPATFYEPNVFDLYSAEELVVVVKEAIFNTVEIIEQSKRKTPITLYG
YHSSLEEQTKFRDMLDSPSYEKIKHMDFSDLNPEKLHLKTQKCLSSLNEQYPLHRGAIYL
SDPGEIKLLLSNRNESQINQQIEQGAPPIYVGKTPAHLAVISGNMAMLDELIAKKADLSL
QDYDGKTALHYAAECGNMQIMGKILKVVLSQEDAIKVLNIKDNHGKTAFHYAAEFGTPEL
ISAL

Ligands and cofactors

IDNameFormulaCopies
PO4Phosphate ionO4 P4
C5PCytidine-5'-monophosphateC9 H14 N3 O8 P2

Water and common crystallization additives (GOL) are not listed.

Primary citation

Structure of the Legionella Effector Ankx Reveals the Mechanism of Phosphocholine Transfer by the Fic Domain. Campanacci, V., Mukherjee, S., Roy, C.R. et al. EMBO J (2013) 32:1469. DOI 10.1038/EMBOJ.2013.82 · PubMed

Other PDB entries of the same protein (UniProt Q5ZXN6 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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