The structure of HDAC1 in complex with the dimeric ELM2-SANT domain of MTA1 from the NuRD complex. Determined by X-ray diffraction at 3.0 Å resolution. Released 3 Jul 2013.
Explore 4BKX in 3D Show helices and sheets RCSB PDB PDBe
4BKX contains 27 α-helices and 17 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 175-182 | 8 | |
| β-strand | 195-199 | 5 | 1 |
| α-helix | 207-224 | 18 | |
| α-helix | 238-246 | 9 | |
| α-helix | 248-260 | 13 | |
| α-helix | 265-272 | 8 | |
| α-helix | 284-287 | 4 | |
| α-helix | 290-303 | 14 | |
| α-helix | 307-313 | 7 | |
| α-helix | 320-330 | 11 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 11-14 | 4 | 1 |
| α-helix | 19-21 | 3 | |
| α-helix | 33-44 | 12 | |
| α-helix | 48-50 | 3 | |
| β-strand | 52-56 | 5 | 1 |
| α-helix | 57-60 | 4 | |
| α-helix | 61-64 | 4 | |
| α-helix | 70-78 | 9 | |
| α-helix | 88-94 | 7 | |
| β-strand | 96 | 1 | 2 |
| β-strand | 100 | 1 | 2 |
| α-helix | 106-125 | 20 | |
| β-strand | 131-134 | 4 | 1 |
| β-strand | 148 | 1 | 3 |
| β-strand | 151 | 1 | 3 |
| α-helix | 155-163 | 9 | |
| β-strand | 170-174 | 5 | 1 |
| α-helix | 181-186 | 6 | |
| β-strand | 193-200 | 8 | 1 |
| α-helix | 217-219 | 3 | |
| β-strand | 223-228 | 6 | 1 |
| α-helix | 234-252 | 19 | |
| β-strand | 256-260 | 5 | 1 |
| α-helix | 263-265 | 3 | |
| β-strand | 266 | 1 | 4 |
| β-strand | 276 | 1 | 4 |
| α-helix | 278-289 | 12 | |
| β-strand | 295-298 | 4 | 1 |
| α-helix | 305-319 | 15 | |
| β-strand | 327 | 1 | 5 |
| α-helix | 328-330 | 3 | |
| α-helix | 334-336 | 3 | |
| β-strand | 342 | 1 | 5 |
| α-helix | 356-371 | 16 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Metastasis-associated protein MTA1 | A | protein | 176 | HOMO SAPIENS | Q13330 (AlphaFold model) |
| Histone deacetylase 1 | B | protein | 482 | HOMO SAPIENS | Q13547 (AlphaFold model) |
>4BKX_1 METASTASIS-ASSOCIATED PROTEIN MTA1 (chains A) GAADKGEIRVGNRYQADITDLLKEGEEDGRDQSRLETQVWEAHNPLTDKQIDQFLVVARS VGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPV LCRDEMEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDR
>4BKX_2 HISTONE DEACETYLASE 1 (chains B) MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK LA
| ID | Name | Formula | Copies |
|---|---|---|---|
| ZN | Zinc ion | Zn | 1 |
Water and common crystallization additives (ACT, K, SO4) are not listed.
Class I Hdacs Share a Common Mechanism of Regulation by Inositol Phosphates. Millard, C.J., Watson, P.J., Celardo, I. et al. Mol Cell (2013) 51:57. DOI 10.1016/J.MOLCEL.2013.05.020 · PubMed
Other PDB entries of the same protein (UniProt Q13330 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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